TY - JOUR
T1 - Contact heat evoked potentials
T2 - Normal values and use in small-fiber neuropathy
AU - Lagerburg, Vera
AU - Bakkers, Mayienne
AU - Bouwhuis, Anne
AU - Hoeijmakers, Janneke G.J.
AU - Smit, Arjen M.
AU - Van Den Berg, Sofia J.M.
AU - Hordijk-De Boer, Ineke
AU - Brouwer-Van Der Lee, Mardien D.G.
AU - Kranendonk, Douwe
AU - Reulen, Jos P.H.
AU - Faber, Catharina G.
AU - Merkies, Ingemar S.J.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Introduction: Contact heat evoked potentials (CHEPs) may be an objective, non-invasive diagnostic tool in small-fiber neuropathy (SFN). This study establishes normal CHEP values and examines their applicability in SFN patients. Methods: Standardized CHEPs were administered at the wrist and ankle. The N2 and P2 latencies and N2-P2 peak-peak amplitude were recorded by electroencephalography. We examined healthy subjects (n=97), stratified by age and gender, and SFN patients with abnormal intraepidermal nerve fiber density (n=42). CHEP reproducibility and interobserver values were also investigated. Results: CHEP normative values were determined. There was a 9-16% increase in latency per centimeter of height with increasing age. Amplitudes were higher in women than men, and decreased (17-71%) with aging. Test-retest reproducibility and interobserver values were >0.61 and >0.96, respectively. CHEPs were abnormal in 73.8% of the patients. Conclusion: In this study we have established normal values, reliability, and clinical applicability of CHEPs in SFN.
AB - Introduction: Contact heat evoked potentials (CHEPs) may be an objective, non-invasive diagnostic tool in small-fiber neuropathy (SFN). This study establishes normal CHEP values and examines their applicability in SFN patients. Methods: Standardized CHEPs were administered at the wrist and ankle. The N2 and P2 latencies and N2-P2 peak-peak amplitude were recorded by electroencephalography. We examined healthy subjects (n=97), stratified by age and gender, and SFN patients with abnormal intraepidermal nerve fiber density (n=42). CHEP reproducibility and interobserver values were also investigated. Results: CHEP normative values were determined. There was a 9-16% increase in latency per centimeter of height with increasing age. Amplitudes were higher in women than men, and decreased (17-71%) with aging. Test-retest reproducibility and interobserver values were >0.61 and >0.96, respectively. CHEPs were abnormal in 73.8% of the patients. Conclusion: In this study we have established normal values, reliability, and clinical applicability of CHEPs in SFN.
KW - Contact heat evoked potentials
KW - Polyneuropathy
KW - Quantitative sensory testing
KW - Reference values
KW - Small-fiber neuropathy
UR - http://www.scopus.com/inward/record.url?scp=84928215398&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/mus.24465
DO - https://doi.org/10.1002/mus.24465
M3 - Article
C2 - 25256002
SN - 0148-639X
VL - 51
SP - 743
EP - 749
JO - Muscle and Nerve
JF - Muscle and Nerve
IS - 5
ER -