Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs

Dariusch Reza Hadizadeh; Vera Catharina Keil; Gregor Jost; Hubertus Pietsch; Martin Weibrecht; Christian Marx; Winfried Willinek

doi:https://doi.org/10.1055/a-0631-4707

Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs

Dariusch Reza Hadizadeh, Vera Catharina Keil, Gregor Jost, Hubertus Pietsch, Martin Weibrecht, Christian Marx, Winfried Willinek

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

Purpose Quantitative and qualitative analysis of gadopentetate dimeglumine (GD) versus standard-dose (sGb) and half-dose (hGb) gadobutrol in thoracoabdominal time-resolved contrast-enhanced magnetic resonance angiography (4D-MRA) with dynamic computed tomography (dCT) as the quantitative reference in minipigs. Materials and Methods 7 anesthetized Goettingen minipigs received thoracoabdominal dCT (0.37s rotation time) and transverse 4D-MRA (0.3s/dynamic frame;) using sGb and hGb. 8 other minipigs received coronal 4D-MRA (1.3s/dynamic frame; sGb, hGb, SGD). dCT attenuation levels were converted into absolute gadolinium concentrations and compared to 4D-MRA peak signal intensities (SI). Bolus lengths were quantified by full width at half maximum (FWHM) measurements. After this comparison of dose effects on SI in transverse 4D-MRA, coronal 4D-MRAs were analyzed regarding both quantitative and qualitative parameters. Results In dCT (transverse 4D-MRA) hGb showed 39.0% (14.5%) lower arterial peak gadolinium concentrations (peak SIs) and 20.6% (33.8%) shorter FWHM compared to sGb. The difference was due to peak plateaus or reversals in 4D-MRA in 5/7 animals. While sGb led to the highest peak SIs, image quality ratings of arteries were rated similarly high with all contrast agent protocols despite a slightly higher SI with sGb. In contrast, venous peak SIs and image quality ratings were significantly higher when using sGb. Conclusion Peak Gd concentrations and 4D-MRA peak SIs are highest with sGB. These differences are most evident in the venous phase leading to superior image quality in multi-phase 4D-MRA. Key Points: Standard-dose gadobutrol offers high vascular gadolinium concentrations and 4D-MRA peak signals. Absolute vascular gadolinium concentrations and 4D-MRA peak signal intensities at 3T diverge. Peak plateaus or reversals cause decreased arterial 4D-MRA peak signals at 3T. Arterial image quality is rated similarly high using different contrast agent protocols. Venous vessel visibility in 4D-MRA is significantly better using standard dose gadobutrol. Citation Format Hadizadeh DR, Keil VC, Jost G etal. Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs. Fortschr Röntgenstr 2018; 190: 747-757.

Original language	English
Pages (from-to)	747-757
Number of pages	11
Journal	Rofo-fortschritte auf dem gebiet der rontgenstrahlen und der bildgebenden verfahren
Volume	190
Issue number	8
DOIs	https://doi.org/10.1055/a-0631-4707 https://doi.org/10.1055/a-0631-4707
Publication status	Published - 1 Aug 2018
Externally published	Yes

Keywords

Animals
Aorta/diagnostic imaging
Contrast Media/administration & dosage
Dose-Response Relationship, Drug
Evaluation Studies as Topic
Female
Gadolinium DTPA/administration & dosage
Image Enhancement/methods
Image Interpretation, Computer-Assisted
Magnetic Resonance Angiography/methods
Male
Organometallic Compounds/administration & dosage
Qualitative Research
Swine
Swine, Miniature
Time Factors
Tomography, X-Ray Computed

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Hadizadeh, D. R., Keil, V. C., Jost, G., Pietsch, H., Weibrecht, M., Marx, C., & Willinek, W. (2018). Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs. Rofo-fortschritte auf dem gebiet der rontgenstrahlen und der bildgebenden verfahren, 190(8), 747-757. https://doi.org/10.1055/a-0631-4707, https://doi.org/10.1055/a-0631-4707

@article{100a48f84b7c4f39b330142e2eeecf0f,

title = "Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs",

abstract = "Purpose Quantitative and qualitative analysis of gadopentetate dimeglumine (GD) versus standard-dose (sGb) and half-dose (hGb) gadobutrol in thoracoabdominal time-resolved contrast-enhanced magnetic resonance angiography (4D-MRA) with dynamic computed tomography (dCT) as the quantitative reference in minipigs. Materials and Methods 7 anesthetized Goettingen minipigs received thoracoabdominal dCT (0.37s rotation time) and transverse 4D-MRA (0.3s/dynamic frame;) using sGb and hGb. 8 other minipigs received coronal 4D-MRA (1.3s/dynamic frame; sGb, hGb, SGD). dCT attenuation levels were converted into absolute gadolinium concentrations and compared to 4D-MRA peak signal intensities (SI). Bolus lengths were quantified by full width at half maximum (FWHM) measurements. After this comparison of dose effects on SI in transverse 4D-MRA, coronal 4D-MRAs were analyzed regarding both quantitative and qualitative parameters. Results In dCT (transverse 4D-MRA) hGb showed 39.0% (14.5%) lower arterial peak gadolinium concentrations (peak SIs) and 20.6% (33.8%) shorter FWHM compared to sGb. The difference was due to peak plateaus or reversals in 4D-MRA in 5/7 animals. While sGb led to the highest peak SIs, image quality ratings of arteries were rated similarly high with all contrast agent protocols despite a slightly higher SI with sGb. In contrast, venous peak SIs and image quality ratings were significantly higher when using sGb. Conclusion Peak Gd concentrations and 4D-MRA peak SIs are highest with sGB. These differences are most evident in the venous phase leading to superior image quality in multi-phase 4D-MRA. Key Points: Standard-dose gadobutrol offers high vascular gadolinium concentrations and 4D-MRA peak signals. Absolute vascular gadolinium concentrations and 4D-MRA peak signal intensities at 3T diverge. Peak plateaus or reversals cause decreased arterial 4D-MRA peak signals at 3T. Arterial image quality is rated similarly high using different contrast agent protocols. Venous vessel visibility in 4D-MRA is significantly better using standard dose gadobutrol. Citation Format Hadizadeh DR, Keil VC, Jost G etal. Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs. Fortschr R{\"o}ntgenstr 2018; 190: 747-757.",

keywords = "Animals, Aorta/diagnostic imaging, Contrast Media/administration & dosage, Dose-Response Relationship, Drug, Evaluation Studies as Topic, Female, Gadolinium DTPA/administration & dosage, Image Enhancement/methods, Image Interpretation, Computer-Assisted, Magnetic Resonance Angiography/methods, Male, Organometallic Compounds/administration & dosage, Qualitative Research, Swine, Swine, Miniature, Time Factors, Tomography, X-Ray Computed",

author = "Hadizadeh, {Dariusch Reza} and Keil, {Vera Catharina} and Gregor Jost and Hubertus Pietsch and Martin Weibrecht and Christian Marx and Winfried Willinek",

note = "{\textcopyright} Georg Thieme Verlag KG Stuttgart · New York.",

year = "2018",

month = aug,

day = "1",

doi = "https://doi.org/10.1055/a-0631-4707",

language = "English",

volume = "190",

pages = "747--757",

journal = "Rofo-fortschritte auf dem gebiet der rontgenstrahlen und der bildgebenden verfahren",

issn = "1438-9029",

publisher = "Georg Thieme Verlag",

number = "8",

}

Hadizadeh, DR, Keil, VC, Jost, G, Pietsch, H, Weibrecht, M, Marx, C & Willinek, W 2018, 'Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs', Rofo-fortschritte auf dem gebiet der rontgenstrahlen und der bildgebenden verfahren, vol. 190, no. 8, pp. 747-757. https://doi.org/10.1055/a-0631-4707, https://doi.org/10.1055/a-0631-4707

Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs. / Hadizadeh, Dariusch Reza; Keil, Vera Catharina; Jost, Gregor et al.
In: Rofo-fortschritte auf dem gebiet der rontgenstrahlen und der bildgebenden verfahren, Vol. 190, No. 8, 01.08.2018, p. 747-757.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Contrast Media in Time-Resolved MRA at 3T

T2 - A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs

AU - Hadizadeh, Dariusch Reza

AU - Keil, Vera Catharina

AU - Jost, Gregor

AU - Pietsch, Hubertus

AU - Weibrecht, Martin

AU - Marx, Christian

AU - Willinek, Winfried

N1 - © Georg Thieme Verlag KG Stuttgart · New York.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Purpose Quantitative and qualitative analysis of gadopentetate dimeglumine (GD) versus standard-dose (sGb) and half-dose (hGb) gadobutrol in thoracoabdominal time-resolved contrast-enhanced magnetic resonance angiography (4D-MRA) with dynamic computed tomography (dCT) as the quantitative reference in minipigs. Materials and Methods 7 anesthetized Goettingen minipigs received thoracoabdominal dCT (0.37s rotation time) and transverse 4D-MRA (0.3s/dynamic frame;) using sGb and hGb. 8 other minipigs received coronal 4D-MRA (1.3s/dynamic frame; sGb, hGb, SGD). dCT attenuation levels were converted into absolute gadolinium concentrations and compared to 4D-MRA peak signal intensities (SI). Bolus lengths were quantified by full width at half maximum (FWHM) measurements. After this comparison of dose effects on SI in transverse 4D-MRA, coronal 4D-MRAs were analyzed regarding both quantitative and qualitative parameters. Results In dCT (transverse 4D-MRA) hGb showed 39.0% (14.5%) lower arterial peak gadolinium concentrations (peak SIs) and 20.6% (33.8%) shorter FWHM compared to sGb. The difference was due to peak plateaus or reversals in 4D-MRA in 5/7 animals. While sGb led to the highest peak SIs, image quality ratings of arteries were rated similarly high with all contrast agent protocols despite a slightly higher SI with sGb. In contrast, venous peak SIs and image quality ratings were significantly higher when using sGb. Conclusion Peak Gd concentrations and 4D-MRA peak SIs are highest with sGB. These differences are most evident in the venous phase leading to superior image quality in multi-phase 4D-MRA. Key Points: Standard-dose gadobutrol offers high vascular gadolinium concentrations and 4D-MRA peak signals. Absolute vascular gadolinium concentrations and 4D-MRA peak signal intensities at 3T diverge. Peak plateaus or reversals cause decreased arterial 4D-MRA peak signals at 3T. Arterial image quality is rated similarly high using different contrast agent protocols. Venous vessel visibility in 4D-MRA is significantly better using standard dose gadobutrol. Citation Format Hadizadeh DR, Keil VC, Jost G etal. Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs. Fortschr Röntgenstr 2018; 190: 747-757.

AB - Purpose Quantitative and qualitative analysis of gadopentetate dimeglumine (GD) versus standard-dose (sGb) and half-dose (hGb) gadobutrol in thoracoabdominal time-resolved contrast-enhanced magnetic resonance angiography (4D-MRA) with dynamic computed tomography (dCT) as the quantitative reference in minipigs. Materials and Methods 7 anesthetized Goettingen minipigs received thoracoabdominal dCT (0.37s rotation time) and transverse 4D-MRA (0.3s/dynamic frame;) using sGb and hGb. 8 other minipigs received coronal 4D-MRA (1.3s/dynamic frame; sGb, hGb, SGD). dCT attenuation levels were converted into absolute gadolinium concentrations and compared to 4D-MRA peak signal intensities (SI). Bolus lengths were quantified by full width at half maximum (FWHM) measurements. After this comparison of dose effects on SI in transverse 4D-MRA, coronal 4D-MRAs were analyzed regarding both quantitative and qualitative parameters. Results In dCT (transverse 4D-MRA) hGb showed 39.0% (14.5%) lower arterial peak gadolinium concentrations (peak SIs) and 20.6% (33.8%) shorter FWHM compared to sGb. The difference was due to peak plateaus or reversals in 4D-MRA in 5/7 animals. While sGb led to the highest peak SIs, image quality ratings of arteries were rated similarly high with all contrast agent protocols despite a slightly higher SI with sGb. In contrast, venous peak SIs and image quality ratings were significantly higher when using sGb. Conclusion Peak Gd concentrations and 4D-MRA peak SIs are highest with sGB. These differences are most evident in the venous phase leading to superior image quality in multi-phase 4D-MRA. Key Points: Standard-dose gadobutrol offers high vascular gadolinium concentrations and 4D-MRA peak signals. Absolute vascular gadolinium concentrations and 4D-MRA peak signal intensities at 3T diverge. Peak plateaus or reversals cause decreased arterial 4D-MRA peak signals at 3T. Arterial image quality is rated similarly high using different contrast agent protocols. Venous vessel visibility in 4D-MRA is significantly better using standard dose gadobutrol. Citation Format Hadizadeh DR, Keil VC, Jost G etal. Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs. Fortschr Röntgenstr 2018; 190: 747-757.

KW - Animals

KW - Aorta/diagnostic imaging

KW - Contrast Media/administration & dosage

KW - Dose-Response Relationship, Drug

KW - Evaluation Studies as Topic

KW - Female

KW - Gadolinium DTPA/administration & dosage

KW - Image Enhancement/methods

KW - Image Interpretation, Computer-Assisted

KW - Magnetic Resonance Angiography/methods

KW - Male

KW - Organometallic Compounds/administration & dosage

KW - Qualitative Research

KW - Swine

KW - Swine, Miniature

KW - Time Factors

KW - Tomography, X-Ray Computed

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UR - https://www.ncbi.nlm.nih.gov/pubmed/30045399

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DO - https://doi.org/10.1055/a-0631-4707

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SN - 1438-9029

VL - 190

SP - 747

EP - 757

JO - Rofo-fortschritte auf dem gebiet der rontgenstrahlen und der bildgebenden verfahren

JF - Rofo-fortschritte auf dem gebiet der rontgenstrahlen und der bildgebenden verfahren

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Hadizadeh DR, Keil VC, Jost G, Pietsch H, Weibrecht M, Marx C et al. Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs. Rofo-fortschritte auf dem gebiet der rontgenstrahlen und der bildgebenden verfahren. 2018 Aug 1;190(8):747-757. doi: https://doi.org/10.1055/a-0631-4707, https://doi.org/10.1055/a-0631-4707

Contrast Media in Time-Resolved MRA at 3T: A Systematic Quantitative and Qualitative Analysis of Concentration and Dose Effects on Image Parameters in Minipigs

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