Convalescent Plasma in a Patient with Protracted COVID-19 and Secondary Hypogammaglobulinemia Due to Chronic Lymphocytic Leukemia: Buying Time to Develop Immunity?

Jaap L. J. Hanssen; Johan Stienstra; Stefan A. Boers; Cilia R. Pothast; Hans L. Zaaijer; Jennifer M. Tjon; Mirjam H. M. Heemskerk; Mariet C. W. Feltkamp; Sandra M. Arend

doi:https://doi.org/10.3390/idr13040077

Convalescent Plasma in a Patient with Protracted COVID-19 and Secondary Hypogammaglobulinemia Due to Chronic Lymphocytic Leukemia: Buying Time to Develop Immunity?

Jaap L. J. Hanssen, Johan Stienstra, Stefan A. Boers, Cilia R. Pothast, Hans L. Zaaijer, Jennifer M. Tjon, Mirjam H. M. Heemskerk, Mariet C. W. Feltkamp, Sandra M. Arend

AII - Infectious diseases (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

It is not exactly clear yet which type of immune response prevails to accomplish viral clearance in coronavirus disease 2019 (COVID-19). Studying a patient with chronic lymphocytic leukemia and hypogammaglobulinemia who suffered from COVID-19 provided insight in the immunological responses after treatment with COVID-19 convalescent plasma (CCP). Treatment consisted of oxygen, repeated glucocorticosteroids and multiple dosages of CCP guided by antibody levels. Retrospectively performed humoral and cellular immunity analysis made clear that not every serological test for COVID-19 is appropriate for follow-up of sufficient neutralizing antibodies after CCP. In retrospect, we think that CCP merely bought time for this patient to develop an adequate cellular immune response which led to viral clearance and ultimately clinical recovery.

Original language	English
Pages (from-to)	855-864
Number of pages	10
Journal	Infectious disease reports
Volume	13
Issue number	4
DOIs	https://doi.org/10.3390/idr13040077
Publication status	Published - 2021

Keywords

COVID-19
Chronic lymphocytic leukemia
Convalescent plasma
In vitro T cell assay

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Hanssen, J. L. J., Stienstra, J., Boers, S. A., Pothast, C. R., Zaaijer, H. L., Tjon, J. M., Heemskerk, M. H. M., Feltkamp, M. C. W., & Arend, S. M. (2021). Convalescent Plasma in a Patient with Protracted COVID-19 and Secondary Hypogammaglobulinemia Due to Chronic Lymphocytic Leukemia: Buying Time to Develop Immunity? Infectious disease reports, 13(4), 855-864. https://doi.org/10.3390/idr13040077

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title = "Convalescent Plasma in a Patient with Protracted COVID-19 and Secondary Hypogammaglobulinemia Due to Chronic Lymphocytic Leukemia: Buying Time to Develop Immunity?",

abstract = "It is not exactly clear yet which type of immune response prevails to accomplish viral clearance in coronavirus disease 2019 (COVID-19). Studying a patient with chronic lymphocytic leukemia and hypogammaglobulinemia who suffered from COVID-19 provided insight in the immunological responses after treatment with COVID-19 convalescent plasma (CCP). Treatment consisted of oxygen, repeated glucocorticosteroids and multiple dosages of CCP guided by antibody levels. Retrospectively performed humoral and cellular immunity analysis made clear that not every serological test for COVID-19 is appropriate for follow-up of sufficient neutralizing antibodies after CCP. In retrospect, we think that CCP merely bought time for this patient to develop an adequate cellular immune response which led to viral clearance and ultimately clinical recovery.",

keywords = "COVID-19, Chronic lymphocytic leukemia, Convalescent plasma, In vitro T cell assay",

author = "Hanssen, {Jaap L. J.} and Johan Stienstra and Boers, {Stefan A.} and Pothast, {Cilia R.} and Zaaijer, {Hans L.} and Tjon, {Jennifer M.} and Heemskerk, {Mirjam H. M.} and Feltkamp, {Mariet C. W.} and Arend, {Sandra M.}",

note = "Funding Information: The authors thank the patient described in this report for his cooperation and all medical personnel caring for or providing diagnostic facilities to COVID-19 patients for their continuous efforts in these unusual times. Publisher Copyright: {\textcopyright} 2021 Page Press Publications. All rights reserved.",

year = "2021",

doi = "https://doi.org/10.3390/idr13040077",

language = "English",

volume = "13",

pages = "855--864",

journal = "Infectious disease reports",

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Hanssen, JLJ, Stienstra, J, Boers, SA, Pothast, CR, Zaaijer, HL, Tjon, JM, Heemskerk, MHM, Feltkamp, MCW & Arend, SM 2021, 'Convalescent Plasma in a Patient with Protracted COVID-19 and Secondary Hypogammaglobulinemia Due to Chronic Lymphocytic Leukemia: Buying Time to Develop Immunity?', Infectious disease reports, vol. 13, no. 4, pp. 855-864. https://doi.org/10.3390/idr13040077

Convalescent Plasma in a Patient with Protracted COVID-19 and Secondary Hypogammaglobulinemia Due to Chronic Lymphocytic Leukemia: Buying Time to Develop Immunity? / Hanssen, Jaap L. J.; Stienstra, Johan; Boers, Stefan A. et al.
In: Infectious disease reports, Vol. 13, No. 4, 2021, p. 855-864.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Stienstra, Johan

AU - Boers, Stefan A.

AU - Pothast, Cilia R.

AU - Zaaijer, Hans L.

AU - Tjon, Jennifer M.

AU - Heemskerk, Mirjam H. M.

AU - Feltkamp, Mariet C. W.

AU - Arend, Sandra M.

N1 - Funding Information: The authors thank the patient described in this report for his cooperation and all medical personnel caring for or providing diagnostic facilities to COVID-19 patients for their continuous efforts in these unusual times. Publisher Copyright: © 2021 Page Press Publications. All rights reserved.

PY - 2021

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AB - It is not exactly clear yet which type of immune response prevails to accomplish viral clearance in coronavirus disease 2019 (COVID-19). Studying a patient with chronic lymphocytic leukemia and hypogammaglobulinemia who suffered from COVID-19 provided insight in the immunological responses after treatment with COVID-19 convalescent plasma (CCP). Treatment consisted of oxygen, repeated glucocorticosteroids and multiple dosages of CCP guided by antibody levels. Retrospectively performed humoral and cellular immunity analysis made clear that not every serological test for COVID-19 is appropriate for follow-up of sufficient neutralizing antibodies after CCP. In retrospect, we think that CCP merely bought time for this patient to develop an adequate cellular immune response which led to viral clearance and ultimately clinical recovery.

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ER -

Convalescent Plasma in a Patient with Protracted COVID-19 and Secondary Hypogammaglobulinemia Due to Chronic Lymphocytic Leukemia: Buying Time to Develop Immunity?

Abstract

Keywords

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