TY - JOUR
T1 - Correlation between the number of patient-reported adverse events, adverse drug events, and quality of life in older patients
T2 - an observational study
AU - Beerlage-Davids, Cathelijn J.
AU - Ponjee, Godelieve H. M.
AU - Vanhommerig, Joost W.
AU - Kuper, Ingeborg M. J. A.
AU - Karapinar-Çarkit, Fatma
N1 - Funding Information: We would like to express our gratitude to the patients involved in this study. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2022/12
Y1 - 2022/12
N2 - Background: Previous studies on medication therapy management services, e.g. medication reconciliation and medication review, do not show consistent improvements in patient’s health-related quality of life. However, these services can reduce adverse drug events. Aim: To evaluate the correlation between health-related quality of life and adverse events/adverse drug events reported by patients. Method: Older patients (≥ 65 years) with polypharmacy (≥ 5 medicines) admitted to orthopaedic or surgical wards were included. Patients were contacted post-discharge to evaluate patient-reported adverse events, health-related quality of life using the EuroQol questionnaire and self-perceived health status on a 5-point Likert scale. The outcomes were the correlation between health-related quality of life and the number of adverse events/adverse drug events, and potential predictors for these events. Spearman correlation and Poisson regression were used for data analysis. Results: 102 patients were included. The correlation between health-related quality of life and adverse events was weak but significant (Spearman correlation coefficient: − 0.328, p = 0.001). No correlation was found for adverse drug events (− 0.064, p = 0.521). Self-perceived health status was a predictor for adverse events, not for adverse drug events. Health-related quality of life was neither a predictor for adverse events, nor for adverse drug events. Conclusion: The correlation between the number of patient-reported adverse events, adverse drug events and health-related quality of life measured by the EuroQol was weak. There is a need for a questionnaire that includes the impact of medication use and is sensitive to outcomes that are affected by medication therapy management services.
AB - Background: Previous studies on medication therapy management services, e.g. medication reconciliation and medication review, do not show consistent improvements in patient’s health-related quality of life. However, these services can reduce adverse drug events. Aim: To evaluate the correlation between health-related quality of life and adverse events/adverse drug events reported by patients. Method: Older patients (≥ 65 years) with polypharmacy (≥ 5 medicines) admitted to orthopaedic or surgical wards were included. Patients were contacted post-discharge to evaluate patient-reported adverse events, health-related quality of life using the EuroQol questionnaire and self-perceived health status on a 5-point Likert scale. The outcomes were the correlation between health-related quality of life and the number of adverse events/adverse drug events, and potential predictors for these events. Spearman correlation and Poisson regression were used for data analysis. Results: 102 patients were included. The correlation between health-related quality of life and adverse events was weak but significant (Spearman correlation coefficient: − 0.328, p = 0.001). No correlation was found for adverse drug events (− 0.064, p = 0.521). Self-perceived health status was a predictor for adverse events, not for adverse drug events. Health-related quality of life was neither a predictor for adverse events, nor for adverse drug events. Conclusion: The correlation between the number of patient-reported adverse events, adverse drug events and health-related quality of life measured by the EuroQol was weak. There is a need for a questionnaire that includes the impact of medication use and is sensitive to outcomes that are affected by medication therapy management services.
KW - Adverse drug events
KW - Adverse events
KW - Health-related quality of life
KW - Medication therapy management
KW - Patient-reported outcome measures
UR - http://www.scopus.com/inward/record.url?scp=85139839775&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s11096-022-01481-w
DO - https://doi.org/10.1007/s11096-022-01481-w
M3 - Article
C2 - 36243833
SN - 2210-7703
VL - 44
SP - 1434
EP - 1441
JO - International Journal of Clinical Pharmacy
JF - International Journal of Clinical Pharmacy
IS - 6
ER -