TY - JOUR
T1 - Cortical abnormalities associated with pediatric and adult obsessive-compulsive disorder
T2 - Findings from the ENIGMA obsessive-compulsive disorder working group
AU - ENIGMA OCD Working Group
AU - Boedhoe, Premika S.W.
AU - Schmaal, Lianne
AU - Abe, Yoshinari
AU - Alonso, Pino
AU - Ameis, Stephanie H.
AU - Anticevic, Alan
AU - Arnold, Paul D.
AU - Batistuzzo, Marcelo C.
AU - Benedetti, Francesco
AU - Beucke, Jan C.
AU - Bollettini, Irene
AU - Bose, Anushree
AU - Brem, Silvia
AU - Calvo, Anna
AU - Calvo, Rosa
AU - Cheng, Yuqi
AU - Cho, Kang Ik K.
AU - Ciullo, Valentina
AU - Dallaspezia, Sara
AU - Denys, Damiaan
AU - Feusner, Jamie D.
AU - Fitzgerald, Kate D.
AU - Fouche, Jean Paul
AU - Fridgeirsson, Egill A.
AU - Gruner, Patricia
AU - Hanna, Gregory L.
AU - Hibar, Derrek P.
AU - Hoexter, Marcelo Q.
AU - Hu, Hao
AU - Huyser, Chaim
AU - Jahanshad, Neda
AU - James, Anthony
AU - Kathmann, Norbert
AU - Kaufmann, Christian
AU - Koch, Kathrin
AU - Kwon, Jun Soo
AU - Lazaro, Luisa
AU - Lochner, Christine
AU - Marsh, Rachel
AU - Martínez-Zalacaín, Ignacio
AU - Mataix-Cols, David
AU - Menchón, José M.
AU - Minuzzi, Luciano
AU - Morer, Astrid
AU - Nakamae, Takashi
AU - Nakao, Tomohiro
AU - Narayanaswamy, Janardhanan C.
AU - Nishida, Seiji
AU - Nurmi, Erika
AU - Van Den Heuvel, Odile A.
AU - van Wingen, Guido A.
AU - AUTHOR GROUP
AU - Figee, Martijn
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Objective: Brain imaging studies of structural abnormalities in OCD have yielded inconsistent results, partly because of limited statistical power, clinical heterogeneity, and methodological differences. The authors conducted meta- and mega-analyses comprising the largest study of cortical morphometry in OCD ever undertaken. Method: T1-weighted MRI scans of 1,905 OCD patients and 1,760 healthy controls from 27 sites worldwide were processed locally using FreeSurfer to assess cortical thickness and surface area. Effect sizes for differences between patients and controls, and associations with clinical characteristics, were calculated using linear regression models controlling for age, sex, site, and intracranial volume. Results: In adult OCD patients versus controls, we found a significantly lower surface area for the transverse temporal cortexand a thinner inferiorparietalcortex.Medicated adult OCD patients also showed thinner cortices throughout the brain. In pediatric OCD patients compared with controls, we found significantly thinner inferior and superior parietal cortices, but none of the regions analyzed showedsignificant differences in surface area. However, medicated pediatric OCD patients had lower surface area in frontal regions. Cohen's d effect sizes varied from 20.10 to 20.33. Conclusions: The parietal cortex was consistently implicated in both adults and children with OCD. More widespread cortical thickness abnormalities were found in medicated adult OCD patients, and more pronounced surface area deficits (mainly in frontal regions) were found in medicated pediatric OCD patients. These cortical measures represent distinct morphological features and may be differentially affected during different stages of development and illness, and possibly moderated by disease profile and medication.
AB - Objective: Brain imaging studies of structural abnormalities in OCD have yielded inconsistent results, partly because of limited statistical power, clinical heterogeneity, and methodological differences. The authors conducted meta- and mega-analyses comprising the largest study of cortical morphometry in OCD ever undertaken. Method: T1-weighted MRI scans of 1,905 OCD patients and 1,760 healthy controls from 27 sites worldwide were processed locally using FreeSurfer to assess cortical thickness and surface area. Effect sizes for differences between patients and controls, and associations with clinical characteristics, were calculated using linear regression models controlling for age, sex, site, and intracranial volume. Results: In adult OCD patients versus controls, we found a significantly lower surface area for the transverse temporal cortexand a thinner inferiorparietalcortex.Medicated adult OCD patients also showed thinner cortices throughout the brain. In pediatric OCD patients compared with controls, we found significantly thinner inferior and superior parietal cortices, but none of the regions analyzed showedsignificant differences in surface area. However, medicated pediatric OCD patients had lower surface area in frontal regions. Cohen's d effect sizes varied from 20.10 to 20.33. Conclusions: The parietal cortex was consistently implicated in both adults and children with OCD. More widespread cortical thickness abnormalities were found in medicated adult OCD patients, and more pronounced surface area deficits (mainly in frontal regions) were found in medicated pediatric OCD patients. These cortical measures represent distinct morphological features and may be differentially affected during different stages of development and illness, and possibly moderated by disease profile and medication.
UR - http://www.scopus.com/inward/record.url?scp=85046475329&partnerID=8YFLogxK
U2 - https://doi.org/10.1176/appi.ajp.2017.17050485
DO - https://doi.org/10.1176/appi.ajp.2017.17050485
M3 - Article
C2 - 29377733
SN - 0002-953X
VL - 175
SP - 453
EP - 462
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 5
ER -