Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years

Karolinska Schizophrenia Project (KaSP); Fabrice Crivello; Anders M. Dale; Christopher Davey; Greig I. Zubicaray; Erin W. Dickie; Annabella Di Giorgio; Nhat Trung Doan; Erlend S. Dørum; Stefan Ehrlich; Susanne Erk; Thomas Espeseth; Helena Fatouros‐bergman; Simon E. Fisher; Jean‐paul Fouche; Barbara Franke; Thomas Frodl; Paola Fuentes‐claramonte; David C. Glahn; Ian H. Gotlib; Hans‐jörgen Grabe; Oliver Grimm; Nynke A. Groenewold; Dominik Grotegerd; Oliver Gruber; Patricia Gruner; Rachel E. Gur; Ruben C. Gur; Ben J. Harrison; Sean N. Hatton; Andreas Heinz; Derrek P. Hibar; Ian B. Hickie; Beng‐choon Ho; Pieter J. Hoekstra; Sarah Hohmann; Avram J. Holmes; Martine Hoogman; Norbert Hosten; Fleur M. Howells; Hilleke E. Hulshoff Pol; Neda Jahanshad; Anthony James; Terry L. Jernigan; Jiyang Jiang; Erik G. Jönsson; John A. Joska; Rene Kahn; Andrew Kalnin; Ryota Kanai; Marieke Klein; Tatyana P. Klyushnik; Sanne Koops; Bernd Krämer; Jonna Kuntsi; Jim Lagopoulos; Luisa Lázaro; Irina Lebedeva; Won Hee Lee; Klaus‐peter Lesch; Christine Lochner; Sophie Maingault; Nicholas G. Martin; Ignacio Martínez‐zalacaín; David Mataix‐cols; Bernard Mazoyer; Colm Mcdonald; Brenna C. Mcdonald; Andrew M. Mcintosh; Katie L. Mcmahon; Genevieve Mcphilemy; José M. Menchón; Sarah E. Medland; Andreas Meyer‐lindenberg; Jilly Naaijen; Pablo Najt; Tomohiro Nakao; Jan E. Nordvik; Lars Nyberg; Víctor Ortiz‐garcía Foz; Yannis Paloyelis; Paul Pauli; Giulio Pergola; Edith Pomarol‐clotet; Maria J. Portella; Steven G. Potkin; Joaquim Radua; Andreas Reif; Daniel A. Rinker; Joshua L. Roffman; Pedro G. P. Rosa; Matthew D. Sacchet; Perminder S. Sachdev; Raymond Salvador; Pascual Sánchez‐juan; Salvador Sarró; Theodore D. Satterthwaite; Andrew J. Saykin; Mauricio H. Serpa; Knut Schnell; Gunter Schumann; Kang Sim; Jordan W. Smoller; Iris Sommer; Carles Soriano‐mas; Dan J. Stein; Lachlan T. Strike; Suzanne C. Swagerman; Christian K. Tamnes; Henk S. Temmingh; Sophia I. Thomopoulos; Alexander S. Tomyshev; Diana Tordesillas‐gutiérrez; Julian N. Trollor; Jessica A. Turner; Anne Uhlmann; Dennis Meer; Nic J. A. Wee; Neeltje E. M. Haren; Dennis van't Ent; Theo G. M. Erp; Aristotle Voineskos; Henry Völzke; Henrik Walter; Esther Walton; Lei Wang; Yang Wang; Thomas H. Wassink; Bernd Weber; Wei Wen; John D. West; Lars T. Westlye; Heather Whalley; Lara M. Wierenga; Katharina Wittfeld; Daniel H. Wolf; Amanda Worker; Margaret J. Wright; Kun Yang; Yulyia Yoncheva; Marcus V. Zanetti; Georg C. Ziegler; Paul M. Thompson; Danai Dima

doi:https://doi.org/10.1002/hbm.25364

Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years

Karolinska Schizophrenia Project (KaSP), Fabrice Crivello, Anders M. Dale, Christopher Davey, Greig I. Zubicaray, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dørum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros‐bergman, Simon E. Fisher, Jean‐paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes‐claramonte, David C. Glahn, Ian H. GotlibHans‐jörgen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Sean N. Hatton, Andreas Heinz, Derrek P. Hibar, Ian B. Hickie, Beng‐choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jönsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Sanne Koops, Bernd Krämer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lázaro, Irina Lebedeva, Won Hee Lee, Klaus‐peter Lesch, Christine Lochner, Sophie Maingault, Nicholas G. Martin, Ignacio Martínez‐zalacaín, David Mataix‐cols, Bernard Mazoyer, Colm Mcdonald, Brenna C. Mcdonald, Andrew M. Mcintosh, Katie L. Mcmahon, Genevieve Mcphilemy, José M. Menchón, Sarah E. Medland, Andreas Meyer‐lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Víctor Ortiz‐garcía Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol‐clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sánchez‐juan, Salvador Sarró, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano‐mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia I. Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas‐gutiérrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Dennis Meer, Nic J. A. Wee, Neeltje E. M. Haren, Dennis van't Ent, Theo G. M. Erp, Aristotle Voineskos, Henry Völzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus V. Zanetti, Georg C. Ziegler, Paul M. Thompson, Danai Dima

Research output: Contribution to journal › Article › Academic › peer-review

100 Citations (Scopus)

Abstract

Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3–90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.

Original language	English
Pages (from-to)	431-451
Number of pages	21
Journal	Human brain mapping
Volume	43
Issue number	1
Early online date	17 Feb 2021
DOIs	https://doi.org/10.1002/hbm.25364
Publication status	Published - Jan 2022

Keywords

aging
cortical thickness
development
trajectories

Access to Document

https://doi.org/10.1002/hbm.25364

Cite this

Karolinska Schizophrenia Project (KaSP), Crivello, F., Dale, A. M., Davey, C., Zubicaray, G. I., Dickie, E. W., Di Giorgio, A., Doan, N. T., Dørum, E. S., Ehrlich, S., Erk, S., Espeseth, T., Fatouros‐bergman, H., Fisher, S. E., Fouche, J., Franke, B., Frodl, T., Fuentes‐claramonte, P., Glahn, D. C., ... Dima, D. (2022). Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years. Human brain mapping, 43(1), 431-451. https://doi.org/10.1002/hbm.25364

@article{f172cbeb2c3249c7b27e54e8c17a918d,

title = "Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years",

abstract = "Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3–90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.",

keywords = "aging, cortical thickness, development, trajectories",

author = "{Karolinska Schizophrenia Project (KaSP)} and Sophia Frangou and Amirhossein Modabbernia and Williams, {Steven C.R.} and Efstathios Papachristou and Doucet, {Gaelle E.} and Ingrid Agartz and Moji Aghajani and Akudjedu, {Theophilus N.} and Anton Albajes-Eizagirre and Dag Aln{\ae}s and Alpert, {Kathryn I.} and Micael Andersson and Andreasen, {Nancy C.} and Andreassen, {Ole A.} and Philip Asherson and Tobias Banaschewski and Nuria Bargallo and Sarah Baumeister and Ramona Baur-Streubel and Alessandro Bertolino and Aurora Bonvino and Boomsma, {Dorret I.} and Stefan Borgwardt and Josiane Bourque and Daniel Brandeis and Alan Breier and Henry Brodaty and Brouwer, {Rachel M.} and Buitelaar, {Jan K.} and Busatto, {Geraldo F.} and Buckner, {Randy L.} and Vincent Calhoun and Canales-Rodr{\'i}guez, {Erick J.} and Cannon, {Dara M.} and Xavier Caseras and Castellanos, {Francisco X.} and Simon Cervenka and Chaim-Avancini, {Tiffany M.} and Ching, {Christopher R.K.} and Victoria Chubar and Clark, {Vincent P.} and Patricia Conrod and Annette Conzelmann and Benedicto Crespo-Facorro and {de Geus}, {Eco J.C.} and {den Braber}, Anouk and Machielsen, {Marise W.J.} and Jaap Oosterlaan and {van den Heuvel}, {Odile A.} and Veltman, {Dick J.} and Fabrice Crivello and Crone, {Eveline A.} and Dale, {Anders M.} and Christopher Davey and Lieuwe Haan and Zubicaray, {Greig I.} and Dickie, {Erin W.} and {Di Giorgio}, Annabella and Doan, {Nhat Trung} and D{\o}rum, {Erlend S.} and Stefan Ehrlich and Susanne Erk and Thomas Espeseth and Helena Fatouros‐bergman and Fisher, {Simon E.} and Jean‐paul Fouche and Barbara Franke and Thomas Frodl and Paola Fuentes‐claramonte and Glahn, {David C.} and Gotlib, {Ian H.} and Hans‐j{\"o}rgen Grabe and Oliver Grimm and Groenewold, {Nynke A.} and Dominik Grotegerd and Oliver Gruber and Patricia Gruner and Gur, {Rachel E.} and Gur, {Ruben C.} and Harrison, {Ben J.} and Hartman, {Catharine A.} and Hatton, {Sean N.} and Andreas Heinz and Heslenfeld, {Dirk J.} and Hibar, {Derrek P.} and Hickie, {Ian B.} and Beng‐choon Ho and Hoekstra, {Pieter J.} and Sarah Hohmann and Holmes, {Avram J.} and Martine Hoogman and Norbert Hosten and Howells, {Fleur M.} and {Hulshoff Pol}, {Hilleke E.} and Chaim Huyser and Neda Jahanshad and Anthony James and Jernigan, {Terry L.} and Jiyang Jiang and J{\"o}nsson, {Erik G.} and Joska, {John A.} and Rene Kahn and Andrew Kalnin and Ryota Kanai and Marieke Klein and Klyushnik, {Tatyana P.} and Laura Koenders and Sanne Koops and Bernd Kr{\"a}mer and Jonna Kuntsi and Jim Lagopoulos and Luisa L{\'a}zaro and Irina Lebedeva and Lee, {Won Hee} and Klaus‐peter Lesch and Christine Lochner and Sophie Maingault and Martin, {Nicholas G.} and Ignacio Mart{\'i}nez‐zalaca{\'i}n and David Mataix‐cols and Bernard Mazoyer and Colm Mcdonald and Mcdonald, {Brenna C.} and Mcintosh, {Andrew M.} and Mcmahon, {Katie L.} and Genevieve Mcphilemy and Mench{\'o}n, {Jos{\'e} M.} and Medland, {Sarah E.} and Andreas Meyer‐lindenberg and Jilly Naaijen and Pablo Najt and Tomohiro Nakao and Nordvik, {Jan E.} and Lars Nyberg and Foz, {V{\'i}ctor Ortiz‐garc{\'i}a} and Yannis Paloyelis and Paul Pauli and Giulio Pergola and Edith Pomarol‐clotet and Portella, {Maria J.} and Potkin, {Steven G.} and Joaquim Radua and Andreas Reif and Rinker, {Daniel A.} and Roffman, {Joshua L.} and Rosa, {Pedro G. P.} and Sacchet, {Matthew D.} and Sachdev, {Perminder S.} and Raymond Salvador and Pascual S{\'a}nchez‐juan and Salvador Sarr{\'o} and Satterthwaite, {Theodore D.} and Saykin, {Andrew J.} and Serpa, {Mauricio H.} and Lianne Schmaal and Knut Schnell and Gunter Schumann and Kang Sim and Smoller, {Jordan W.} and Iris Sommer and Carles Soriano‐mas and Stein, {Dan J.} and Strike, {Lachlan T.} and Swagerman, {Suzanne C.} and Tamnes, {Christian K.} and Temmingh, {Henk S.} and Thomopoulos, {Sophia I.} and Tomyshev, {Alexander S.} and Diana Tordesillas‐guti{\'e}rrez and Trollor, {Julian N.} and Turner, {Jessica A.} and Anne Uhlmann and Dennis Meer and Wee, {Nic J. A.} and Haren, {Neeltje E. M.} and {van't Ent}, Dennis and Erp, {Theo G. M.} and Veer, {Ilya M.} and Aristotle Voineskos and Henry V{\"o}lzke and Henrik Walter and Esther Walton and Lei Wang and Yang Wang and Wassink, {Thomas H.} and Bernd Weber and Wei Wen and West, {John D.} and Westlye, {Lars T.} and Heather Whalley and Wierenga, {Lara M.} and Katharina Wittfeld and Wolf, {Daniel H.} and Amanda Worker and Wright, {Margaret J.} and Kun Yang and Yulyia Yoncheva and Zanetti, {Marcus V.} and Ziegler, {Georg C.} and Thompson, {Paul M.} and Danai Dima",

note = "Funding Information: Hans J{\"o}rgen Grabe: Travel grants and speaker honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag; reseach funding from Fresenius Medical Care. Ole A Andreasen: Consultant to HealthLytix, speaker honorarium from Lundbeck. Anders M Dale: Founder and member of the Scientific Advisory Board CorTechs Labs, Inc where he holds equity; member of the Scientific Advisory of Human Longevity Inc; research grants with General Electric Healthcare. Publisher Copyright: {\textcopyright} 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2022",

month = jan,

doi = "https://doi.org/10.1002/hbm.25364",

language = "English",

volume = "43",

pages = "431--451",

journal = "Human brain mapping",

issn = "1065-9471",

publisher = "Wiley-Liss Inc.",

number = "1",

}

Karolinska Schizophrenia Project (KaSP), Crivello, F, Dale, AM, Davey, C, Zubicaray, GI, Dickie, EW, Di Giorgio, A, Doan, NT, Dørum, ES, Ehrlich, S, Erk, S, Espeseth, T, Fatouros‐bergman, H, Fisher, SE, Fouche, J, Franke, B, Frodl, T, Fuentes‐claramonte, P, Glahn, DC, Gotlib, IH, Grabe, H, Grimm, O, Groenewold, NA, Grotegerd, D, Gruber, O, Gruner, P, Gur, RE, Gur, RC, Harrison, BJ, Hatton, SN, Heinz, A, Hibar, DP, Hickie, IB, Ho, B, Hoekstra, PJ, Hohmann, S, Holmes, AJ, Hoogman, M, Hosten, N, Howells, FM, Hulshoff Pol, HE, Jahanshad, N, James, A, Jernigan, TL, Jiang, J, Jönsson, EG, Joska, JA, Kahn, R, Kalnin, A, Kanai, R, Klein, M, Klyushnik, TP, Koops, S, Krämer, B, Kuntsi, J, Lagopoulos, J, Lázaro, L, Lebedeva, I, Lee, WH, Lesch, K, Lochner, C, Maingault, S, Martin, NG, Martínez‐zalacaín, I, Mataix‐cols, D, Mazoyer, B, Mcdonald, C, Mcdonald, BC, Mcintosh, AM, Mcmahon, KL, Mcphilemy, G, Menchón, JM, Medland, SE, Meyer‐lindenberg, A, Naaijen, J, Najt, P, Nakao, T, Nordvik, JE, Nyberg, L, Foz, VO, Paloyelis, Y, Pauli, P, Pergola, G, Pomarol‐clotet, E, Portella, MJ, Potkin, SG, Radua, J, Reif, A, Rinker, DA, Roffman, JL, Rosa, PGP, Sacchet, MD, Sachdev, PS, Salvador, R, Sánchez‐juan, P, Sarró, S, Satterthwaite, TD, Saykin, AJ, Serpa, MH, Schnell, K, Schumann, G, Sim, K, Smoller, JW, Sommer, I, Soriano‐mas, C, Stein, DJ, Strike, LT, Swagerman, SC, Tamnes, CK, Temmingh, HS, Thomopoulos, SI, Tomyshev, AS, Tordesillas‐gutiérrez, D, Trollor, JN, Turner, JA, Uhlmann, A, Meer, D, Wee, NJA, Haren, NEM, van't Ent, D, Erp, TGM, Voineskos, A, Völzke, H, Walter, H, Walton, E, Wang, L, Wang, Y, Wassink, TH, Weber, B, Wen, W, West, JD, Westlye, LT, Whalley, H, Wierenga, LM, Wittfeld, K, Wolf, DH, Worker, A, Wright, MJ, Yang, K, Yoncheva, Y, Zanetti, MV, Ziegler, GC, Thompson, PM & Dima, D 2022, 'Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years', Human brain mapping, vol. 43, no. 1, pp. 431-451. https://doi.org/10.1002/hbm.25364

TY - JOUR

T1 - Cortical thickness across the lifespan

T2 - Data from 17,075 healthy individuals aged 3–90 years

AU - Karolinska Schizophrenia Project (KaSP)

AU - Frangou, Sophia

AU - Modabbernia, Amirhossein

AU - Williams, Steven C.R.

AU - Papachristou, Efstathios

AU - Doucet, Gaelle E.

AU - Agartz, Ingrid

AU - Aghajani, Moji

AU - Akudjedu, Theophilus N.

AU - Albajes-Eizagirre, Anton

AU - Alnæs, Dag

AU - Alpert, Kathryn I.

AU - Andersson, Micael

AU - Andreasen, Nancy C.

AU - Andreassen, Ole A.

AU - Asherson, Philip

AU - Banaschewski, Tobias

AU - Bargallo, Nuria

AU - Baumeister, Sarah

AU - Baur-Streubel, Ramona

AU - Bertolino, Alessandro

AU - Bonvino, Aurora

AU - Boomsma, Dorret I.

AU - Borgwardt, Stefan

AU - Bourque, Josiane

AU - Brandeis, Daniel

AU - Breier, Alan

AU - Brodaty, Henry

AU - Brouwer, Rachel M.

AU - Buitelaar, Jan K.

AU - Busatto, Geraldo F.

AU - Buckner, Randy L.

AU - Calhoun, Vincent

AU - Canales-Rodríguez, Erick J.

AU - Cannon, Dara M.

AU - Caseras, Xavier

AU - Castellanos, Francisco X.

AU - Cervenka, Simon

AU - Chaim-Avancini, Tiffany M.

AU - Ching, Christopher R.K.

AU - Chubar, Victoria

AU - Clark, Vincent P.

AU - Conrod, Patricia

AU - Conzelmann, Annette

AU - Crespo-Facorro, Benedicto

AU - de Geus, Eco J.C.

AU - den Braber, Anouk

AU - Machielsen, Marise W.J.

AU - Oosterlaan, Jaap

AU - van den Heuvel, Odile A.

AU - Veltman, Dick J.

AU - Crivello, Fabrice

AU - Crone, Eveline A.

AU - Dale, Anders M.

AU - Davey, Christopher

AU - Haan, Lieuwe

AU - Zubicaray, Greig I.

AU - Dickie, Erin W.

AU - Di Giorgio, Annabella

AU - Doan, Nhat Trung

AU - Dørum, Erlend S.

AU - Ehrlich, Stefan

AU - Erk, Susanne

AU - Espeseth, Thomas

AU - Fatouros‐bergman, Helena

AU - Fisher, Simon E.

AU - Fouche, Jean‐paul

AU - Franke, Barbara

AU - Frodl, Thomas

AU - Fuentes‐claramonte, Paola

AU - Glahn, David C.

AU - Gotlib, Ian H.

AU - Grabe, Hans‐jörgen

AU - Grimm, Oliver

AU - Groenewold, Nynke A.

AU - Grotegerd, Dominik

AU - Gruber, Oliver

AU - Gruner, Patricia

AU - Gur, Rachel E.

AU - Gur, Ruben C.

AU - Harrison, Ben J.

AU - Hartman, Catharine A.

AU - Hatton, Sean N.

AU - Heinz, Andreas

AU - Heslenfeld, Dirk J.

AU - Hibar, Derrek P.

AU - Hickie, Ian B.

AU - Ho, Beng‐choon

AU - Hoekstra, Pieter J.

AU - Hohmann, Sarah

AU - Holmes, Avram J.

AU - Hoogman, Martine

AU - Hosten, Norbert

AU - Howells, Fleur M.

AU - Hulshoff Pol, Hilleke E.

AU - Huyser, Chaim

AU - Jahanshad, Neda

AU - James, Anthony

AU - Jernigan, Terry L.

AU - Jiang, Jiyang

AU - Jönsson, Erik G.

AU - Joska, John A.

AU - Kahn, Rene

AU - Kalnin, Andrew

AU - Kanai, Ryota

AU - Klein, Marieke

AU - Klyushnik, Tatyana P.

AU - Koenders, Laura

AU - Koops, Sanne

AU - Krämer, Bernd

AU - Kuntsi, Jonna

AU - Lagopoulos, Jim

AU - Lázaro, Luisa

AU - Lebedeva, Irina

AU - Lee, Won Hee

AU - Lesch, Klaus‐peter

AU - Lochner, Christine

AU - Maingault, Sophie

AU - Martin, Nicholas G.

AU - Martínez‐zalacaín, Ignacio

AU - Mataix‐cols, David

AU - Mazoyer, Bernard

AU - Mcdonald, Colm

AU - Mcdonald, Brenna C.

AU - Mcintosh, Andrew M.

AU - Mcmahon, Katie L.

AU - Mcphilemy, Genevieve

AU - Menchón, José M.

AU - Medland, Sarah E.

AU - Meyer‐lindenberg, Andreas

AU - Naaijen, Jilly

AU - Najt, Pablo

AU - Nakao, Tomohiro

AU - Nordvik, Jan E.

AU - Nyberg, Lars

AU - Foz, Víctor Ortiz‐garcía

AU - Paloyelis, Yannis

AU - Pauli, Paul

AU - Pergola, Giulio

AU - Pomarol‐clotet, Edith

AU - Portella, Maria J.

AU - Potkin, Steven G.

AU - Radua, Joaquim

AU - Reif, Andreas

AU - Rinker, Daniel A.

AU - Roffman, Joshua L.

AU - Rosa, Pedro G. P.

AU - Sacchet, Matthew D.

AU - Sachdev, Perminder S.

AU - Salvador, Raymond

AU - Sánchez‐juan, Pascual

AU - Sarró, Salvador

AU - Satterthwaite, Theodore D.

AU - Saykin, Andrew J.

AU - Serpa, Mauricio H.

AU - Schmaal, Lianne

AU - Schnell, Knut

AU - Schumann, Gunter

AU - Sim, Kang

AU - Smoller, Jordan W.

AU - Sommer, Iris

AU - Soriano‐mas, Carles

AU - Stein, Dan J.

AU - Strike, Lachlan T.

AU - Swagerman, Suzanne C.

AU - Tamnes, Christian K.

AU - Temmingh, Henk S.

AU - Thomopoulos, Sophia I.

AU - Tomyshev, Alexander S.

AU - Tordesillas‐gutiérrez, Diana

AU - Trollor, Julian N.

AU - Turner, Jessica A.

AU - Uhlmann, Anne

AU - Meer, Dennis

AU - Wee, Nic J. A.

AU - Haren, Neeltje E. M.

AU - van't Ent, Dennis

AU - Erp, Theo G. M.

AU - Veer, Ilya M.

AU - Voineskos, Aristotle

AU - Völzke, Henry

AU - Walter, Henrik

AU - Walton, Esther

AU - Wang, Lei

AU - Wang, Yang

AU - Wassink, Thomas H.

AU - Weber, Bernd

AU - Wen, Wei

AU - West, John D.

AU - Westlye, Lars T.

AU - Whalley, Heather

AU - Wierenga, Lara M.

AU - Wittfeld, Katharina

AU - Wolf, Daniel H.

AU - Worker, Amanda

AU - Wright, Margaret J.

AU - Yang, Kun

AU - Yoncheva, Yulyia

AU - Zanetti, Marcus V.

AU - Ziegler, Georg C.

AU - Thompson, Paul M.

AU - Dima, Danai

N1 - Funding Information: Hans Jörgen Grabe: Travel grants and speaker honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag; reseach funding from Fresenius Medical Care. Ole A Andreasen: Consultant to HealthLytix, speaker honorarium from Lundbeck. Anders M Dale: Founder and member of the Scientific Advisory Board CorTechs Labs, Inc where he holds equity; member of the Scientific Advisory of Human Longevity Inc; research grants with General Electric Healthcare. Publisher Copyright: © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2022/1

Y1 - 2022/1

N2 - Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3–90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.

AB - Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3–90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.

KW - aging

KW - cortical thickness

KW - development

KW - trajectories

UR - http://www.scopus.com/inward/record.url?scp=85101007703&partnerID=8YFLogxK

U2 - https://doi.org/10.1002/hbm.25364

DO - https://doi.org/10.1002/hbm.25364

M3 - Article

C2 - 33595143

SN - 1065-9471

VL - 43

SP - 431

EP - 451

JO - Human brain mapping

JF - Human brain mapping

IS - 1

ER -

Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years

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