TY - JOUR
T1 - Costs of complications following distal pancreatectomy
T2 - a systematic review
AU - van Bodegraven, Eduard A.
AU - Francken, Michiel F. G.
AU - Verkoulen, Koen C. H. A.
AU - Abu Hilal, Mohammad
AU - Dijkgraaf, Marcel G. W.
AU - Besselink, Marc G.
N1 - Funding Information: Authors declare no funding or conflict of interest. Publisher Copyright: © 2023 The Author(s)
PY - 2023/10
Y1 - 2023/10
N2 - Background: Postoperative complications following distal pancreatectomy (DP) are common, especially postoperative pancreatic fistula (POPF). In order to design adequate prophylactic strategies, it is of relevance to determine the costs of these complications. An overview of the literature on the costs of complications following DP is lacking. Methods: A systematic literature search was performed in PubMed, Embase, and Cochrane Library (inception until 1 August 2022). The primary outcome was the costs (i.e. cost differential) of major morbidity, individual complications and prolonged hospital stay. Quality of non-RCTs were assessed using the Newcastle–Ottawa scale. Costs were compared with the use of Purchasing Power parity. This systematic review was registered with PROSPERO (CRD42021223019). Results: Overall, seven studies were included with 854 patients after DP. The rate POPF grade B/C varied between 13% and 27% (based on five studies) with a corresponding cost differential of EUR 18,389 (based on two studies). The rate of severe morbidity varied between 13% and 38% (based on five studies) with a corresponding cost differential of EUR 19,281 (based on five studies). Conclusion: This systematic review reported considerable costs for POPF grade B/C and severe morbidity after DP. Prospective databases and studies should report on all complications in a uniform matter to better display the economic burden of complications of DP.
AB - Background: Postoperative complications following distal pancreatectomy (DP) are common, especially postoperative pancreatic fistula (POPF). In order to design adequate prophylactic strategies, it is of relevance to determine the costs of these complications. An overview of the literature on the costs of complications following DP is lacking. Methods: A systematic literature search was performed in PubMed, Embase, and Cochrane Library (inception until 1 August 2022). The primary outcome was the costs (i.e. cost differential) of major morbidity, individual complications and prolonged hospital stay. Quality of non-RCTs were assessed using the Newcastle–Ottawa scale. Costs were compared with the use of Purchasing Power parity. This systematic review was registered with PROSPERO (CRD42021223019). Results: Overall, seven studies were included with 854 patients after DP. The rate POPF grade B/C varied between 13% and 27% (based on five studies) with a corresponding cost differential of EUR 18,389 (based on two studies). The rate of severe morbidity varied between 13% and 38% (based on five studies) with a corresponding cost differential of EUR 19,281 (based on five studies). Conclusion: This systematic review reported considerable costs for POPF grade B/C and severe morbidity after DP. Prospective databases and studies should report on all complications in a uniform matter to better display the economic burden of complications of DP.
UR - http://www.scopus.com/inward/record.url?scp=85163876450&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.hpb.2023.03.007
DO - https://doi.org/10.1016/j.hpb.2023.03.007
M3 - Review article
C2 - 37391314
SN - 1365-182X
VL - 25
SP - 1145
EP - 1150
JO - HPB
JF - HPB
IS - 10
ER -