Cross-sectional and Longitudinal Relationships between Perceived Stress and C-reactive Protein in Men and Women.

C. Barbosa-Leiker, V. Roper, S. McPherson, M. Lei, B. Wright, T. Hoekstra, M. Kostick

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To date, an examination of the longitudinal relationship between perceived stress and C-reactive protein (CRP) is limited. We explored the relationship between perceived stress and CRP concurrently and across 2 and 4years in 383 men and women. Multiple linear regressions examined the cross-sectional and longitudinal relationships between baseline stress and counter-stress scores with CRP at baseline, 2years after baseline and 4years after baseline, while controlling for covariates (age, smoking status, anti-inflammatory use, oral contraceptive use, physical activity, menopausal status, years since onset of menopause, post-menopausal hormone use and body mass index). Results indicate that stress and counter-stress were not related to CRP in either men or women at study baseline or 2years later. Across a 4-year time frame, higher stress values were related to higher CRP values in women, but not men. Counter-stress was not related to CRP values in men or women across the 4years. This study highlights the importance of examining the cross-sectional and longitudinal relationship between perceived stress and inflammation separately in men and women. Copyright © 2013 John Wiley & Sons, Ltd. © 2013 John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)158-165
Issue number2
Publication statusPublished - 2014

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