Crucial role of interleukin-4 in the survival of colon cancer stem cells

Maria Giovanna Francipane, Mileidys Perez Alea, Ylenia Lombardo, Matilde Todaro, J. P. Medema, Giorgio Stassi

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Colon tumors may be maintained by a rare fraction of cancer stem-like cells (CSC) that express the cell surface marker CD133. Self-renewing CSCs exhibit relatively greater resistance to clinical cytotoxic therapies and recent work suggests that this resistance may be mediated in part by an autocrine response to the immune cytokine interleukin 4 (IL-4). Blocking IL-4 signaling can sensitize CSCs to apoptotic stimuli and increase the in vivo efficacy of cytotoxic therapy. These findings suggest that inhibitors of IL-4 signaling may offer a new therapeutic tool in colon carcinoma
Original languageEnglish
Pages (from-to)4022-4025
JournalCancer Research
Volume68
Issue number11
DOIs
Publication statusPublished - 2008

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