CSF levels of angiogenesis-related proteins in patients with leptomeningeal metastases

J. C. Reijneveld; D. Brandsma; W. Boogerd; J. G.M. Bonfrer; S. Kalmijn; E. E. Voest; A. Geurts-Moespot; M. C. Visser; M. J.B. Taphoorn

doi:https://doi.org/10.1212/01.wnl.0000178981.39984.c2

CSF levels of angiogenesis-related proteins in patients with leptomeningeal metastases

J. C. Reijneveld, D. Brandsma, W. Boogerd, J. G.M. Bonfrer, S. Kalmijn, E. E. Voest, A. Geurts-Moespot, M. C. Visser, M. J.B. Taphoorn

Neurology (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

30 Citations (Scopus)

Abstract

The authors determined the levels of vascular endothelial growth factor (VEGF) and urokinase-type plasminogen activator (uPA) in the CSF of patients with leptomeningeal metastases (LM; n = 53), cancer patients without LM (n = 18), and subjects without malignancy (n = 25). Median levels of uPA and VEGF were significantly higher in patients with LM, supporting the hypothesis that angiogenesis contributes to LM. VEGF was negatively correlated with survival in patients with LM, suggesting its use as a prognostic factor.

Original language	English
Pages (from-to)	1120-1122
Number of pages	3
Journal	Neurology
Volume	65
Issue number	7
DOIs	https://doi.org/10.1212/01.wnl.0000178981.39984.c2
Publication status	Published - 11 Oct 2005

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title = "CSF levels of angiogenesis-related proteins in patients with leptomeningeal metastases",

abstract = "The authors determined the levels of vascular endothelial growth factor (VEGF) and urokinase-type plasminogen activator (uPA) in the CSF of patients with leptomeningeal metastases (LM; n = 53), cancer patients without LM (n = 18), and subjects without malignancy (n = 25). Median levels of uPA and VEGF were significantly higher in patients with LM, supporting the hypothesis that angiogenesis contributes to LM. VEGF was negatively correlated with survival in patients with LM, suggesting its use as a prognostic factor.",

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T1 - CSF levels of angiogenesis-related proteins in patients with leptomeningeal metastases

AU - Reijneveld, J. C.

AU - Brandsma, D.

AU - Boogerd, W.

AU - Bonfrer, J. G.M.

AU - Kalmijn, S.

AU - Voest, E. E.

AU - Geurts-Moespot, A.

AU - Visser, M. C.

AU - Taphoorn, M. J.B.

PY - 2005/10/11

Y1 - 2005/10/11

N2 - The authors determined the levels of vascular endothelial growth factor (VEGF) and urokinase-type plasminogen activator (uPA) in the CSF of patients with leptomeningeal metastases (LM; n = 53), cancer patients without LM (n = 18), and subjects without malignancy (n = 25). Median levels of uPA and VEGF were significantly higher in patients with LM, supporting the hypothesis that angiogenesis contributes to LM. VEGF was negatively correlated with survival in patients with LM, suggesting its use as a prognostic factor.

AB - The authors determined the levels of vascular endothelial growth factor (VEGF) and urokinase-type plasminogen activator (uPA) in the CSF of patients with leptomeningeal metastases (LM; n = 53), cancer patients without LM (n = 18), and subjects without malignancy (n = 25). Median levels of uPA and VEGF were significantly higher in patients with LM, supporting the hypothesis that angiogenesis contributes to LM. VEGF was negatively correlated with survival in patients with LM, suggesting its use as a prognostic factor.

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U2 - https://doi.org/10.1212/01.wnl.0000178981.39984.c2

DO - https://doi.org/10.1212/01.wnl.0000178981.39984.c2

M3 - Article

SN - 0028-3878

VL - 65

SP - 1120

EP - 1122

JO - Neurology

JF - Neurology

IS - 7

ER -

CSF levels of angiogenesis-related proteins in patients with leptomeningeal metastases

Abstract

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