TY - JOUR
T1 - Current Approaches in Managing Colonic Serrated Polyps and Serrated Polyposis
AU - van Toledo, David E. F. W. M.
AU - Ijspeert, Joep E. G.
AU - Dekker, Evelien
N1 - Publisher Copyright: © 2022 Annual Reviews Inc.. All rights reserved.
PY - 2022
Y1 - 2022
N2 - For decades, conventional adenomas were the only known precursor lesions of colorectal cancer (CRC). Accordingly, education and research regarding CRC prevention were mainly focused on adenomas. The groundbreaking discovery that serrated polyps (SPs) also have the potential to develop into CRCs, and seem to account for a considerable proportion of sporadic CRCs, has led to a paradigm shift in the prevention, diagnosis, and treatment of CRC. Studies in recent years have led to our current understanding of SPs and associated CRC, but a lot of work is still to be done to further improve knowledge about this serrated neoplasia pathway and the clinical management of SPs and serrated polyposis syndrome (SPS). In this review, we reflect on the current understanding of SPs with respect to terminology, detection, resection, and surveillance and reflect on the management of SPS.
AB - For decades, conventional adenomas were the only known precursor lesions of colorectal cancer (CRC). Accordingly, education and research regarding CRC prevention were mainly focused on adenomas. The groundbreaking discovery that serrated polyps (SPs) also have the potential to develop into CRCs, and seem to account for a considerable proportion of sporadic CRCs, has led to a paradigm shift in the prevention, diagnosis, and treatment of CRC. Studies in recent years have led to our current understanding of SPs and associated CRC, but a lot of work is still to be done to further improve knowledge about this serrated neoplasia pathway and the clinical management of SPs and serrated polyposis syndrome (SPS). In this review, we reflect on the current understanding of SPs with respect to terminology, detection, resection, and surveillance and reflect on the management of SPS.
KW - Colonoscopy
KW - Polyp
KW - Resection
KW - Screening
KW - Surveillance
UR - http://www.scopus.com/inward/record.url?scp=85123717203&partnerID=8YFLogxK
U2 - https://doi.org/10.1146/annurev-med-042220-024703
DO - https://doi.org/10.1146/annurev-med-042220-024703
M3 - Review article
C2 - 35084990
SN - 0066-4219
VL - 73
SP - 293
EP - 306
JO - Annual review of medicine
JF - Annual review of medicine
ER -