Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

Sjors A. Koppes; Kristiane A. Engebretsen; Tove Agner; Irena Angelova-Fischer; Teresa Berents; Johanna Brandner; Richard Brans; Maja-Lisa Clausen; Edith Hummler; Ivone Jakasa; Ružica Jurakić-Tončic; Swen M. John; Denis Khnykin; Sonja Molin; Jan O. Holm; Sari Suomela; Hermann-Josef Thierse; Sanja Kezic; Stefan F. Martin; Jacob P. Thyssen

doi:https://doi.org/10.1111/cod.12789

Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

Sjors A. Koppes, Kristiane A. Engebretsen, Tove Agner, Irena Angelova-Fischer, Teresa Berents, Johanna Brandner, Richard Brans, Maja-Lisa Clausen, Edith Hummler, Ivone Jakasa, Ružica Jurakić-Tončic, Swen M. John, Denis Khnykin, Sonja Molin, Jan O. Holm, Sari Suomela, Hermann-Josef Thierse, Sanja Kezic, Stefan F. Martin, Jacob P. Thyssen

Research output: Contribution to journal › Review article › Academic › peer-review

60 Citations (Scopus)

Abstract

Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described

Original language	English
Pages (from-to)	1-16
Journal	Contact dermatitis
Volume	77
Issue number	1
Early online date	2017
DOIs	https://doi.org/10.1111/cod.12789
Publication status	Published - 2017

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https://doi.org/10.1111/cod.12789

Cite this

Koppes, S. A., Engebretsen, K. A., Agner, T., Angelova-Fischer, I., Berents, T., Brandner, J., Brans, R., Clausen, M.-L., Hummler, E., Jakasa, I., Jurakić-Tončic, R., John, S. M., Khnykin, D., Molin, S., Holm, J. O., Suomela, S., Thierse, H.-J., Kezic, S., Martin, S. F., & Thyssen, J. P. (2017). Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis. Contact dermatitis, 77(1), 1-16. https://doi.org/10.1111/cod.12789

@article{3e5aa9abe1f449778366d180a7b967b8,

title = "Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis",

abstract = "Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described",

author = "Koppes, {Sjors A.} and Engebretsen, {Kristiane A.} and Tove Agner and Irena Angelova-Fischer and Teresa Berents and Johanna Brandner and Richard Brans and Maja-Lisa Clausen and Edith Hummler and Ivone Jakasa and Ru{\v z}ica Juraki{\'c}-Ton{\v c}ic and John, {Swen M.} and Denis Khnykin and Sonja Molin and Holm, {Jan O.} and Sari Suomela and Hermann-Josef Thierse and Sanja Kezic and Martin, {Stefan F.} and Thyssen, {Jacob P.}",

year = "2017",

doi = "https://doi.org/10.1111/cod.12789",

language = "English",

volume = "77",

pages = "1--16",

journal = "Contact dermatitis",

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Koppes, SA, Engebretsen, KA, Agner, T, Angelova-Fischer, I, Berents, T, Brandner, J, Brans, R, Clausen, M-L, Hummler, E, Jakasa, I, Jurakić-Tončic, R, John, SM, Khnykin, D, Molin, S, Holm, JO, Suomela, S, Thierse, H-J, Kezic, S, Martin, SF & Thyssen, JP 2017, 'Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis', Contact dermatitis, vol. 77, no. 1, pp. 1-16. https://doi.org/10.1111/cod.12789

TY - JOUR

T1 - Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

AU - Koppes, Sjors A.

AU - Engebretsen, Kristiane A.

AU - Agner, Tove

AU - Angelova-Fischer, Irena

AU - Berents, Teresa

AU - Brandner, Johanna

AU - Brans, Richard

AU - Clausen, Maja-Lisa

AU - Hummler, Edith

AU - Jakasa, Ivone

AU - Jurakić-Tončic, Ružica

AU - John, Swen M.

AU - Khnykin, Denis

AU - Molin, Sonja

AU - Holm, Jan O.

AU - Suomela, Sari

AU - Thierse, Hermann-Josef

AU - Kezic, Sanja

AU - Martin, Stefan F.

AU - Thyssen, Jacob P.

PY - 2017

Y1 - 2017

N2 - Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described

AB - Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described

U2 - https://doi.org/10.1111/cod.12789

DO - https://doi.org/10.1111/cod.12789

M3 - Review article

C2 - 28497472

SN - 0105-1873

VL - 77

SP - 1

EP - 16

JO - Contact dermatitis

JF - Contact dermatitis

IS - 1

ER -