TY - JOUR
T1 - Current understanding and future perspectives of brain–heart–kidney axis in psoriatic arthritis
AU - Markousis-Mavrogenis, George
AU - Nurmohamed, Michael T.
AU - Koutsogeorgopoulou, Loukia
AU - Dimitroulas, Theodoros
AU - Katsifis, Gikas
AU - Vartela, Vasiliki
AU - Mitsikostas, Dimos
AU - Kolovou, Genovefa
AU - Tektonidou, Maria
AU - Voulgari, Paraskevi
AU - Sfikakis, Petros P.
AU - Kitas, George D.
AU - Mavrogeni, Sophie I.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Psoriatic arthritis (PsA) patients are at a higher risk of systemic inflammatory sequelae, leading to microalbuminuria, cardiovascular (CVD) and neuropsychiatric (NPD) disease. Our aim is to present the existing literature about the relationship between CVD, kidney and NPD in PsA. The literature evaluation of PsA revealed that chronic T-cell activation and increased levels of circulating immune complexes can cause glomerular injury leading to microalbuminuria, which predicts CVD and all-cause mortality in both diabetic and non-diabetic patients. Furthermore, it is a marker of preclinical brain damage and identifies patients at higher risk of NPD/CVD events. Among the currently used imaging modalities in PsA, magnetic resonance imaging (MRI) maintains a crucial role, because it is ideal for concurrent evaluation of brain/heart involvement and serial follow up assessment. There is increasing evidence regarding the relationship between kidneys, heart and brain in PsA. Although currently there are no official recommendations about a combined brain/heart MRI in PsA, it could be considered in PsA with microalbuminuria, arrhythmia, HF, cognitive dysfunction and/or depression.
AB - Psoriatic arthritis (PsA) patients are at a higher risk of systemic inflammatory sequelae, leading to microalbuminuria, cardiovascular (CVD) and neuropsychiatric (NPD) disease. Our aim is to present the existing literature about the relationship between CVD, kidney and NPD in PsA. The literature evaluation of PsA revealed that chronic T-cell activation and increased levels of circulating immune complexes can cause glomerular injury leading to microalbuminuria, which predicts CVD and all-cause mortality in both diabetic and non-diabetic patients. Furthermore, it is a marker of preclinical brain damage and identifies patients at higher risk of NPD/CVD events. Among the currently used imaging modalities in PsA, magnetic resonance imaging (MRI) maintains a crucial role, because it is ideal for concurrent evaluation of brain/heart involvement and serial follow up assessment. There is increasing evidence regarding the relationship between kidneys, heart and brain in PsA. Although currently there are no official recommendations about a combined brain/heart MRI in PsA, it could be considered in PsA with microalbuminuria, arrhythmia, HF, cognitive dysfunction and/or depression.
KW - Arrhythmia
KW - Cardiovascular disease
KW - Cardiovascular magnetic resonance imaging
KW - Central nervous system disease
KW - Central nervous system magnetic resonance imaging
KW - Cognitive dysfunction
KW - Depression
KW - Heart failure
KW - Psoriatric arthritis
UR - http://www.scopus.com/inward/record.url?scp=85086924062&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00296-020-04633-1
DO - https://doi.org/10.1007/s00296-020-04633-1
M3 - Review article
C2 - 32594220
SN - 0172-8172
VL - 40
SP - 1361
EP - 1368
JO - Rheumatology international
JF - Rheumatology international
IS - 9
ER -