TY - JOUR
T1 - Cuticular drusen: Stars in the sky
AU - Boon, Camiel J. F.
AU - van de Ven, Johannes P. H.
AU - Hoyng, Carel B.
AU - den Hollander, Anneke I.
AU - Klevering, B. Jeroen
PY - 2013/11
Y1 - 2013/11
N2 - Cuticular drusen is a specific clinical subtype of age-related macular degeneration (AMD). This subtype of AMD has an earlier age at onset, a stronger familial component, and genetic factors play a more prominent role in its development than in the general AMD population. In this review, we describe the clinical characteristics and differential diagnosis of cuticular drusen, as well as systemic associations including membranoproliferative glomerulonephritis type II. We discuss recent genetic and pathophysiological insights, and future therapeutic perspectives are highlighted. © 2013 Elsevier Ltd.
AB - Cuticular drusen is a specific clinical subtype of age-related macular degeneration (AMD). This subtype of AMD has an earlier age at onset, a stronger familial component, and genetic factors play a more prominent role in its development than in the general AMD population. In this review, we describe the clinical characteristics and differential diagnosis of cuticular drusen, as well as systemic associations including membranoproliferative glomerulonephritis type II. We discuss recent genetic and pathophysiological insights, and future therapeutic perspectives are highlighted. © 2013 Elsevier Ltd.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84887363298&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/24028794
U2 - https://doi.org/10.1016/j.preteyeres.2013.08.003
DO - https://doi.org/10.1016/j.preteyeres.2013.08.003
M3 - Review article
C2 - 24028794
SN - 1350-9462
VL - 37
SP - 90
EP - 113
JO - Progress in Retinal and Eye Research
JF - Progress in Retinal and Eye Research
ER -