TY - JOUR
T1 - Cutting edge
T2 - Rapid recovery of NKT cells upon institution of highly active antiretroviral therapy for HIV-1 infection
AU - Van Der Vliet, Hans J.J.
AU - Van Vonderen, Marit G.A.
AU - Molling, Johan W.
AU - Bontkes, Hetty J.
AU - Reijm, Martine
AU - Reiss, Peter
AU - Van Agtmael, Michiel A.
AU - Danner, Sven A.
AU - Van Den Eertwegh, Alfons J.M.
AU - Von Blomberg, B. Mary E.
AU - Scheper, Rik J.
PY - 2006/11/1
Y1 - 2006/11/1
N2 - CD1d-restricted NKT cells play important regulatory roles in various immune responses and are rapidly and selectively depleted upon infection with HIV-1. The cause of this selective depletion is incompletely understood, although it is in part due to the high susceptibility of CD4+ NKT cells to direct infection and subsequent cell death by HIV-1. Here, we demonstrate that highly active antiretroviral therapy (HAART) results in the rapid recovery of predominantly CD4- NKT cells with kinetics that are strikingly similar to those of mainstream T cells. As it is well known that the early recovery of mainstream T cells in response to HAART is due to their redistribution from tissues to the circulation, our data suggest that the selective depletion of circulating NKT cells is likely due to a combination of cell death and tissue sequestration and indicates that HAART can improve immune functions by reconstituting both conventional T cells and immunoregulatory NKT cells.
AB - CD1d-restricted NKT cells play important regulatory roles in various immune responses and are rapidly and selectively depleted upon infection with HIV-1. The cause of this selective depletion is incompletely understood, although it is in part due to the high susceptibility of CD4+ NKT cells to direct infection and subsequent cell death by HIV-1. Here, we demonstrate that highly active antiretroviral therapy (HAART) results in the rapid recovery of predominantly CD4- NKT cells with kinetics that are strikingly similar to those of mainstream T cells. As it is well known that the early recovery of mainstream T cells in response to HAART is due to their redistribution from tissues to the circulation, our data suggest that the selective depletion of circulating NKT cells is likely due to a combination of cell death and tissue sequestration and indicates that HAART can improve immune functions by reconstituting both conventional T cells and immunoregulatory NKT cells.
UR - http://www.scopus.com/inward/record.url?scp=33750299519&partnerID=8YFLogxK
U2 - https://doi.org/10.4049/jimmunol.177.9.5775
DO - https://doi.org/10.4049/jimmunol.177.9.5775
M3 - Article
C2 - 17056500
SN - 0022-1767
VL - 177
SP - 5775
EP - 5778
JO - Journal of Immunology
JF - Journal of Immunology
IS - 9
ER -