TY - JOUR
T1 - Cytidine deaminase enzymatic activity is a prognostic biomarker in gemcitabine/platinum-treated advanced non-small-cell lung cancer
T2 - a prospective validation study
AU - Italian Oncological Group of Clinical Research (GOIRC)
AU - Tibaldi, Carmelo
AU - Camerini, Andrea
AU - Tiseo, Marcello
AU - Mazzoni, Francesca
AU - Barbieri, Fausto
AU - Vittimberga, Isabella
AU - Brighenti, Matteo
AU - Boni, Luca
AU - Baldini, Editta
AU - Gilli, Annalisa
AU - Honeywell, Richard
AU - Chartoire, Myriam
AU - Peters, Godefridus J
AU - Giovannetti, Elisa
AU - on behalf of The Italian Oncological Group of Clinical Research (GOIRC)
PY - 2018/11/27
Y1 - 2018/11/27
N2 - BACKGROUND: Cytidine deaminase (CDA) plays a crucial role in the degradation of gemcitabine. In our previous retrospective study, CDA enzymatic activity was the strongest prognostic biomarker of the activity and efficacy of platinum/gemcitabine combinations. The aim of this prospective study was to validate the prognostic role of CDA activity in the first-line treatment of advanced non-small-cell lung cancer.METHODS: A total of 124 untreated patients received standard doses of platinum/gemcitabine. CDA activity was baseline measured in plasma samples by spectrophotometric assay.RESULTS: Using the median CDA level as cut-off, in the patients with high versus low CDA activity the response rate was 25.0% (95% CI, 14.7-37.8) and 54.1% (95% CI, 40.8-66.9), P = 0.0013; the 6-month progression rate was 34.5% (95% CI, 22.6-46.6) and 54.1% (95% CI, 40.9-65.6), HR = 2.01 (95% CI, 1.32-3.06), P < 0.001; the 1-year survival rate was 23.3% (95% CI, 13.6-34.6) and 57.3% (95% CI, 43.9-68.6), HR = 2.20 (95% CI, 1.46-3.34), P = 0.0002, respectively. CDA activity resulted to be an independent prognostic factor for progression and survival at multivariate analysis.CONCLUSIONS: This study validated prospectively the prognostic role of the CDA activity and should prompt larger and adequately designed randomised prospective studies to establish the predictive impact of this test in improving the outcome of selected patients.
AB - BACKGROUND: Cytidine deaminase (CDA) plays a crucial role in the degradation of gemcitabine. In our previous retrospective study, CDA enzymatic activity was the strongest prognostic biomarker of the activity and efficacy of platinum/gemcitabine combinations. The aim of this prospective study was to validate the prognostic role of CDA activity in the first-line treatment of advanced non-small-cell lung cancer.METHODS: A total of 124 untreated patients received standard doses of platinum/gemcitabine. CDA activity was baseline measured in plasma samples by spectrophotometric assay.RESULTS: Using the median CDA level as cut-off, in the patients with high versus low CDA activity the response rate was 25.0% (95% CI, 14.7-37.8) and 54.1% (95% CI, 40.8-66.9), P = 0.0013; the 6-month progression rate was 34.5% (95% CI, 22.6-46.6) and 54.1% (95% CI, 40.9-65.6), HR = 2.01 (95% CI, 1.32-3.06), P < 0.001; the 1-year survival rate was 23.3% (95% CI, 13.6-34.6) and 57.3% (95% CI, 43.9-68.6), HR = 2.20 (95% CI, 1.46-3.34), P = 0.0002, respectively. CDA activity resulted to be an independent prognostic factor for progression and survival at multivariate analysis.CONCLUSIONS: This study validated prospectively the prognostic role of the CDA activity and should prompt larger and adequately designed randomised prospective studies to establish the predictive impact of this test in improving the outcome of selected patients.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056115948&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30405211
U2 - https://doi.org/10.1038/s41416-018-0307-3
DO - https://doi.org/10.1038/s41416-018-0307-3
M3 - Article
C2 - 30405211
SN - 0007-0920
VL - 119
SP - 1326
EP - 1331
JO - British journal of cancer
JF - British journal of cancer
IS - 11
ER -