TY - JOUR
T1 - Cytokines and their association with insulin resistance in obese pregnant women with different levels of physical activity
AU - Nayak, M.
AU - Eekhoff, M. E. W.
AU - Peinhaupt, M.
AU - Heinemann, A.
AU - Desoye, G.
AU - van Poppel, M. N. M.
N1 - ISI Document Delivery No.: CY6TA Times Cited: 2 Cited Reference Count: 34 Nayak, Minakshi Eekhoff, Marelise E. W. Peinhaupt, Miriam Heinemann, Akos Desoye, Gernot van Poppel, Mireille N. M. Van Poppel, Mireille/0000-0001-5694-4324; Heinemann, Akos/0000-0002-8554-2372 Netherlands Organization for Health Research and Development - Netherlands (ZonMw) [6230.0043]; Austrian Science Fund - Austria (FWF) [P22521]; Jubilaumsfonds of the Austrian National Bank - Austria [14263]; PhD Program DK-MOLIN [W1241] The authors declare that they have no conflict of interests. Funding for this work has been provided by The Netherlands Organization for Health Research and Development - Netherlands (ZonMw; Grant number 6230.0043 to M.v.P.), by the Austrian Science Fund - Austria (FWF; Grant number P22521 to A.H.), and the Jubilaumsfonds of the Austrian National Bank - Austria (Grant number 14263 to A.H.). M.P. was funded by the PhD Program DK-MOLIN (W1241). 2 1 5 ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD LONDON CYTOKINE
PY - 2016
Y1 - 2016
N2 - Background: Cytokines contribute to insulin resistance in pregnancy, but the role of distinct cytokines is not fully understood. Objectives: To study whether cytokines produced by tissues other than skeletal muscle are associated with glucose and insulin metabolism activity in overweight and obese women and to study whether these associations can be modified by physical activity. Methods: A longitudinal study with 44 overweight and obese pregnant women was conducted. Changes in cytokines levels (IFN-gamma, IP-10, IL1-alpha MIP1-alpha, adiponectin and leptin) and ICAM1 from early (15 wk) to late (32 wk) pregnancy were determined. Physical activity was measured objectively with accelerometers. In linear regression models, the associations between (changes in) cytokine levels and fasting glucose, fasting insulin and HOMA-IR were studied. Results: Both IFN-gamma and IP-10 levels increased from early to late pregnancy, and adiponectin levels decreased. IFN-gamma and IP-10 were positively associated with fasting glucose, whereas IL-1 alpha , ICAM1 and adiponectin were inversely associated with insulin and insulin resistance. The association of IL-l alpha with insulin and insulin resistance was only found in women with low levels of physical activity. Conclusions: IFN-gamma, IP-10, IL1-alpha, ICAM1, and adiponectin may play a role in glucose and insulin metabolism in pregnancy. The relationship of IL-1 alpha with insulin and insulin resistance might be moderated by levels of physical activity. Further studies are required to confirm the role of these cytokines in glucose and insulin metabolism in obese pregnant women. (C) 2015 Elsevier Ltd. All rights reserved.
AB - Background: Cytokines contribute to insulin resistance in pregnancy, but the role of distinct cytokines is not fully understood. Objectives: To study whether cytokines produced by tissues other than skeletal muscle are associated with glucose and insulin metabolism activity in overweight and obese women and to study whether these associations can be modified by physical activity. Methods: A longitudinal study with 44 overweight and obese pregnant women was conducted. Changes in cytokines levels (IFN-gamma, IP-10, IL1-alpha MIP1-alpha, adiponectin and leptin) and ICAM1 from early (15 wk) to late (32 wk) pregnancy were determined. Physical activity was measured objectively with accelerometers. In linear regression models, the associations between (changes in) cytokine levels and fasting glucose, fasting insulin and HOMA-IR were studied. Results: Both IFN-gamma and IP-10 levels increased from early to late pregnancy, and adiponectin levels decreased. IFN-gamma and IP-10 were positively associated with fasting glucose, whereas IL-1 alpha , ICAM1 and adiponectin were inversely associated with insulin and insulin resistance. The association of IL-l alpha with insulin and insulin resistance was only found in women with low levels of physical activity. Conclusions: IFN-gamma, IP-10, IL1-alpha, ICAM1, and adiponectin may play a role in glucose and insulin metabolism in pregnancy. The relationship of IL-1 alpha with insulin and insulin resistance might be moderated by levels of physical activity. Further studies are required to confirm the role of these cytokines in glucose and insulin metabolism in obese pregnant women. (C) 2015 Elsevier Ltd. All rights reserved.
U2 - https://doi.org/10.1016/j.cyto.2015.11.003
DO - https://doi.org/10.1016/j.cyto.2015.11.003
M3 - Article
C2 - 26546776
SN - 1043-4666
VL - 77
SP - 72
EP - 78
JO - Cytokine Plus
JF - Cytokine Plus
ER -