Cytokines in cervicovaginal washing fluid from patients with cervical neoplasia

Ming Y. Tjiong; Nine Van Der Vange; Jan S. Ter Schegget; Matthé P.M. Burger; Fiebo W.J. Ten Kate; Theo A. Out

doi:https://doi.org/10.1006/cyto.2001.0909

Cytokines in cervicovaginal washing fluid from patients with cervical neoplasia

Ming Y. Tjiong, Nine Van Der Vange, Jan S. Ter Schegget, Matthé P.M. Burger, Fiebo W.J. Ten Kate, Theo A. Out

Research output: Contribution to journal › Article › Academic › peer-review

65 Citations (Scopus)

Abstract

Human papillomavirus (HPV) infections play an important role in the development of cervical neoplasia. To get to a better understanding of the role of cytokines in the development of these neoplasias, we analysed the presence of various cytokines in cervicovaginal washings of healthy volunteers (n = 22), cervical intraepithelial neoplasia (CIN) patients (n = 63) and cervical cancer patients (n = 33). IL-12p40, IL-10, TGF-β1, TNF-α and IL-1β levels were significantly higher in patients with cervical cancer than in controls and CIN patients. The levels of IFN-γ were not different. Our data demonstrate alterations in the local cervical immune environment in cervical cancer patients. This could have important consequences for the further development of immune modulating therapies and vaccination strategies.

Original language	English
Pages (from-to)	357-360
Number of pages	4
Journal	Cytokine
Volume	14
Issue number	6
DOIs	https://doi.org/10.1006/cyto.2001.0909
Publication status	Published - 21 Jun 2001

Keywords

Cervical neoplasia
Cervicovaginal secretion
Interleukins
Mucosal immunology

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title = "Cytokines in cervicovaginal washing fluid from patients with cervical neoplasia",

abstract = "Human papillomavirus (HPV) infections play an important role in the development of cervical neoplasia. To get to a better understanding of the role of cytokines in the development of these neoplasias, we analysed the presence of various cytokines in cervicovaginal washings of healthy volunteers (n = 22), cervical intraepithelial neoplasia (CIN) patients (n = 63) and cervical cancer patients (n = 33). IL-12p40, IL-10, TGF-β1, TNF-α and IL-1β levels were significantly higher in patients with cervical cancer than in controls and CIN patients. The levels of IFN-γ were not different. Our data demonstrate alterations in the local cervical immune environment in cervical cancer patients. This could have important consequences for the further development of immune modulating therapies and vaccination strategies.",

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AU - Tjiong, Ming Y.

AU - Van Der Vange, Nine

AU - Ter Schegget, Jan S.

AU - Burger, Matthé P.M.

AU - Ten Kate, Fiebo W.J.

AU - Out, Theo A.

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AB - Human papillomavirus (HPV) infections play an important role in the development of cervical neoplasia. To get to a better understanding of the role of cytokines in the development of these neoplasias, we analysed the presence of various cytokines in cervicovaginal washings of healthy volunteers (n = 22), cervical intraepithelial neoplasia (CIN) patients (n = 63) and cervical cancer patients (n = 33). IL-12p40, IL-10, TGF-β1, TNF-α and IL-1β levels were significantly higher in patients with cervical cancer than in controls and CIN patients. The levels of IFN-γ were not different. Our data demonstrate alterations in the local cervical immune environment in cervical cancer patients. This could have important consequences for the further development of immune modulating therapies and vaccination strategies.

KW - Cervical neoplasia

KW - Cervicovaginal secretion

KW - Interleukins

KW - Mucosal immunology

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Cytokines in cervicovaginal washing fluid from patients with cervical neoplasia

Abstract

Keywords

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