TY - JOUR
T1 - Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion
AU - Grootjans, Joep
AU - Lenaerts, Kaatje
AU - Buurman, Wim A.
AU - Dejong, Cornelis H. C.
AU - Derikx, Joep P. M.
PY - 2016
Y1 - 2016
N2 - Intestinal ischemia is a frequently observed phenomenon. Morbidity and mortality rates are extraordinarily high and did not improve over the past decades. This is in part attributable to limited knowledge on the pathophysiology of intestinal ischemia-reperfusion (IR) in man, the paucity in preventive and/or therapeutic options and the lack of early diagnostic markers for intestinal ischemia. To improve our knowledge and solve clinically important questions regarding intestinal IR, we developed a human experimental intestinal IR model. With this model, we were able to gain insight into the mechanisms that allow the human gut to withstand short periods of IR without the development of severe inflammatory responses. The purpose of this review is to overview the most relevant recent advances in our understanding of the pathophysiology of human intestinal IR, as well as the (potential) future clinical implications
AB - Intestinal ischemia is a frequently observed phenomenon. Morbidity and mortality rates are extraordinarily high and did not improve over the past decades. This is in part attributable to limited knowledge on the pathophysiology of intestinal ischemia-reperfusion (IR) in man, the paucity in preventive and/or therapeutic options and the lack of early diagnostic markers for intestinal ischemia. To improve our knowledge and solve clinically important questions regarding intestinal IR, we developed a human experimental intestinal IR model. With this model, we were able to gain insight into the mechanisms that allow the human gut to withstand short periods of IR without the development of severe inflammatory responses. The purpose of this review is to overview the most relevant recent advances in our understanding of the pathophysiology of human intestinal IR, as well as the (potential) future clinical implications
U2 - https://doi.org/10.3748/wjg.v22.i9.2760
DO - https://doi.org/10.3748/wjg.v22.i9.2760
M3 - Review article
C2 - 26973414
SN - 1007-9327
VL - 22
SP - 2760
EP - 2770
JO - World journal of gastroenterology
JF - World journal of gastroenterology
IS - 9
ER -