Abstract
Dendritic cells (DC) are present in essentially every tissue where they operate at the interface of innate and acquired immunity by recognizing pathogens and presenting pathogen-derived peptides to T cells. It is becoming clear that not all C-type lectins on DC serve as antigen receptors recognizing pathogens through carbohydrate structures. The C-type lectin DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells. Here we discuss the carbohydrate/protein recognition profile and other features of DC-SIGN that contribute to the potency of DC to control immunity
Original language | English |
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Pages (from-to) | 921-931 |
Number of pages | 11 |
Journal | Journal of leukocyte biology |
Volume | 71 |
Issue number | 6 |
Publication status | Published - Jun 2002 |
Keywords
- Animals
- Cell Adhesion Molecules
- Dendritic Cells/physiology
- Humans
- Lectins, C-Type
- Lectins/physiology
- Mice
- Receptors, Antigen/physiology
- Receptors, Cell Surface/physiology
- Receptors, HIV/physiology