DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review

T B Geijtenbeek, S J van Vliet, G C van Duijnhoven, C G Figdor, Y van Kooyk

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Dendritic cells (DC) capture micro-organisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present in antigenic form to resting T cells and thus initiate adaptive immune responses. Here we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC, but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development.

Original languageEnglish
Pages (from-to)S19-23
JournalPlacenta
Volume22 Suppl A
Issue numberSuppl. A
DOIs
Publication statusPublished - Apr 2001

Keywords

  • Cell Adhesion Molecules
  • Female
  • HIV Envelope Protein gp120/metabolism
  • HIV-1/metabolism
  • Humans
  • Lectins, C-Type
  • Lectins/metabolism
  • Lymph Nodes/metabolism
  • Mucous Membrane/metabolism
  • Placenta/metabolism
  • Pregnancy
  • Pregnancy Complications, Infectious
  • Receptors, Cell Surface/metabolism
  • Receptors, HIV/metabolism
  • T-Lymphocytes/metabolism
  • Viral Proteins/metabolism

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