DC-SIGN and LFA-1: a battle for ligand: a battle for ligand

D. A. Bleijs; T. B. Geijtenbeek; C. G. Figdor; Y. van Kooyk

doi:https://doi.org/10.1016/S1471-4906(01)01974-3

DC-SIGN and LFA-1: a battle for ligand: a battle for ligand

D. A. Bleijs, T. B. Geijtenbeek, C. G. Figdor, Y. van Kooyk

Research output: Contribution to journal › Review article › Academic › peer-review

69 Citations (Scopus)

Abstract

The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity

Original language	English
Pages (from-to)	457-463
Number of pages	7
Journal	Trends in immunology
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/S1471-4906(01)01974-3
Publication status	Published - Aug 2001

Keywords

Animals
Cell Adhesion Molecules/immunology
Dendritic Cells/immunology
Humans
Lectins, C-Type
Lectins/chemistry
Ligands
Lymphocyte Function-Associated Antigen-1/chemistry
Receptors, Cell Surface/chemistry
T-Lymphocytes/immunology

Access to Document

https://doi.org/10.1016/S1471-4906(01)01974-3

Cite this

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title = "DC-SIGN and LFA-1: a battle for ligand: a battle for ligand",

abstract = "The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity",

keywords = "Animals, Cell Adhesion Molecules/immunology, Dendritic Cells/immunology, Humans, Lectins, C-Type, Lectins/chemistry, Ligands, Lymphocyte Function-Associated Antigen-1/chemistry, Receptors, Cell Surface/chemistry, T-Lymphocytes/immunology",

author = "Bleijs, {D. A.} and Geijtenbeek, {T. B.} and Figdor, {C. G.} and {van Kooyk}, Y.",

year = "2001",

month = aug,

doi = "https://doi.org/10.1016/S1471-4906(01)01974-3",

language = "English",

volume = "22",

pages = "457--463",

journal = "Trends in immunology",

issn = "1471-4906",

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TY - JOUR

T1 - DC-SIGN and LFA-1: a battle for ligand

T2 - a battle for ligand

AU - Bleijs, D. A.

AU - Geijtenbeek, T. B.

AU - Figdor, C. G.

AU - van Kooyk, Y.

PY - 2001/8

Y1 - 2001/8

N2 - The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity

AB - The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity

KW - Animals

KW - Cell Adhesion Molecules/immunology

KW - Dendritic Cells/immunology

KW - Humans

KW - Lectins, C-Type

KW - Lectins/chemistry

KW - Ligands

KW - Lymphocyte Function-Associated Antigen-1/chemistry

KW - Receptors, Cell Surface/chemistry

KW - T-Lymphocytes/immunology

U2 - https://doi.org/10.1016/S1471-4906(01)01974-3

DO - https://doi.org/10.1016/S1471-4906(01)01974-3

M3 - Review article

C2 - 11473836

SN - 1471-4906

VL - 22

SP - 457

EP - 463

JO - Trends in immunology

JF - Trends in immunology

IS - 8

ER -