Debate: Should Preimplantation Genetic Screening or Preimplantation Genetic Diagnosis Be Performed in Recurrent Pregnancy Loss? No

Spontaneous pregnancy loss can be due to several factors either maternal or fetal. Embryo/fetal chromosomal abnormalities are the most common factor involved in spontaneous miscarriages, accounting for about 50% of all pregnancy losses before the 15th week of gestation.1 The term recurrent pregnancy loss (RPL) is widely accepted as the loss of two or more pregnancies from the same partners, and affects up to 5% of couples of reproductive age.2 Common causes for RPL are immunological, endocrine, anatomic, or genetic factors, but about 50% of RPL cases still remain unexplained, or idiopathic. In this group of patients, fetal chromosomal abnormalities have been reported to be the most common cause of RPL, accounting for up to 55% of cases, thus leaving a remainder of 24.5% of truly unexplained RPLs.3.