Decreased cerebrospinal fluid amyloid beta (1-40) levels in frontotemporal lobar degeneration

Y. A.L. Pijnenburg, S. N.M. Schoonenboom, P. D. Mehta, S. P. Mehta, C. Mulder, R. Veerhuis, M. A. Blankenstein, P. Scheltens

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)


The role of amyloid metabolism in the pathophysiology of frontotemporal lobar degeneration (FTLD) has yet to be elucidated. We compared CSF levels of amyloid beta 1-40 (AP40) and amyloid beta 1-42 (Aβ42) in patients with FTLD (n = 21) versus patients with Alzheimer's disease (AD, n = 39) and in control subjects (n = 30). While in AD cases Aβ42 levels were lower and CSF Aβ40 levels equal to those in controls, a significant decrease in Aβ40 and increase in the CSF Aβ42/ Aβ40 ratio was observed in FTLD compared with AD and control subjects. These findings favour a differential involvement of amyloid β peptides in FTLD compared with AD.

Original languageEnglish
Pages (from-to)735-737
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number7
Publication statusPublished - 1 Jul 2007

Cite this