Decreased cerebrospinal fluid amyloid beta (1-40) levels in frontotemporal lobar degeneration

Y. A.L. Pijnenburg; S. N.M. Schoonenboom; P. D. Mehta; S. P. Mehta; C. Mulder; R. Veerhuis; M. A. Blankenstein; P. Scheltens

doi:https://doi.org/10.1136/jnnp.2006.105064

Decreased cerebrospinal fluid amyloid beta (1-40) levels in frontotemporal lobar degeneration

Y. A.L. Pijnenburg, S. N.M. Schoonenboom, P. D. Mehta, S. P. Mehta, C. Mulder, R. Veerhuis, M. A. Blankenstein, P. Scheltens

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Abstract

The role of amyloid metabolism in the pathophysiology of frontotemporal lobar degeneration (FTLD) has yet to be elucidated. We compared CSF levels of amyloid beta 1-40 (AP40) and amyloid beta 1-42 (Aβ42) in patients with FTLD (n = 21) versus patients with Alzheimer's disease (AD, n = 39) and in control subjects (n = 30). While in AD cases Aβ42 levels were lower and CSF Aβ40 levels equal to those in controls, a significant decrease in Aβ40 and increase in the CSF Aβ42/ Aβ40 ratio was observed in FTLD compared with AD and control subjects. These findings favour a differential involvement of amyloid β peptides in FTLD compared with AD.

Original language	English
Pages (from-to)	735-737
Number of pages	3
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	78
Issue number	7
DOIs	https://doi.org/10.1136/jnnp.2006.105064
Publication status	Published - 1 Jul 2007

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title = "Decreased cerebrospinal fluid amyloid beta (1-40) levels in frontotemporal lobar degeneration",

abstract = "The role of amyloid metabolism in the pathophysiology of frontotemporal lobar degeneration (FTLD) has yet to be elucidated. We compared CSF levels of amyloid beta 1-40 (AP40) and amyloid beta 1-42 (Aβ42) in patients with FTLD (n = 21) versus patients with Alzheimer's disease (AD, n = 39) and in control subjects (n = 30). While in AD cases Aβ42 levels were lower and CSF Aβ40 levels equal to those in controls, a significant decrease in Aβ40 and increase in the CSF Aβ42/ Aβ40 ratio was observed in FTLD compared with AD and control subjects. These findings favour a differential involvement of amyloid β peptides in FTLD compared with AD.",

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AU - Pijnenburg, Y. A.L.

AU - Schoonenboom, S. N.M.

AU - Mehta, P. D.

AU - Mehta, S. P.

AU - Mulder, C.

AU - Veerhuis, R.

AU - Blankenstein, M. A.

AU - Scheltens, P.

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Decreased cerebrospinal fluid amyloid beta (1-40) levels in frontotemporal lobar degeneration

Abstract

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