TY - JOUR
T1 - Dectin-1 activation induces proliferation and migration of human keratinocytes enhancing wound re-epithelialization
AU - van den Berg, Linda M.
AU - Zijlstra-Willems, Esther M.
AU - Richters, Cornelia D.
AU - Ulrich, Magda M. W.
AU - Geijtenbeek, Teunis B. H.
PY - 2014
Y1 - 2014
N2 - Beta-glucans in temporary wound dressings have immuno-stimulatory capacities and have been shown to enhance wound healing in burn patients. Curdlan is a 1,3-linked bacterial/fungal derived beta-glucan that induces inflammatory responses via the C-type lectin receptor dectin-1 on dendritic cells (DCs). Here we investigated the effect of beta-glucan curdlan and the role of dectin-1 expressed by keratinocytes (KCs) in wound healing. Curdlan enhanced migration, proliferation and wound closure of human KCs in a dectin-1 dependent manner, both in vitro and ex vivo. Our data suggest that curdlan induces human KC proliferation and migration and could therefore be used in creams to enhance wound healing
AB - Beta-glucans in temporary wound dressings have immuno-stimulatory capacities and have been shown to enhance wound healing in burn patients. Curdlan is a 1,3-linked bacterial/fungal derived beta-glucan that induces inflammatory responses via the C-type lectin receptor dectin-1 on dendritic cells (DCs). Here we investigated the effect of beta-glucan curdlan and the role of dectin-1 expressed by keratinocytes (KCs) in wound healing. Curdlan enhanced migration, proliferation and wound closure of human KCs in a dectin-1 dependent manner, both in vitro and ex vivo. Our data suggest that curdlan induces human KC proliferation and migration and could therefore be used in creams to enhance wound healing
U2 - https://doi.org/10.1016/j.cellimm.2014.03.007
DO - https://doi.org/10.1016/j.cellimm.2014.03.007
M3 - Article
C2 - 24721111
SN - 0008-8749
VL - 289
SP - 49
EP - 54
JO - Cellular Immunology
JF - Cellular Immunology
IS - 1-2
ER -