TY - JOUR
T1 - Deficiency of the complement regulator CD59a exacerbates Wallerian degeneration
AU - Ramaglia, Valeria
AU - King, Rosalind Helen Mary
AU - Morgan, Bryan Paul
AU - Baas, Frank
PY - 2009
Y1 - 2009
N2 - The complement system is implicated in Wallerian degeneration (WD). We have previously shown that the membrane attack complex (MAC) the terminal activation product of the complement cascade, mediates rapid axonal degradation and myelin clearance during WD after peripheral nerve injury. In this study we analyzed the contribution of CD59a, a cell membrane negative regulator of the MAC, to WD. Following injury, the level of MAC deposition was higher in the CD59a deficient mice than wildtypes whereas the residual axonal content was lower in CD59a deficient mice than wildtypes, strongly implicating MAC as a determinant of axonal damage during WD. The number of endoneurial macrophages was significantly higher in CD59a deficient mice compared to wildtypes at 1 day post-injury. These findings are relevant to the understanding of the mechanisms of axon loss in injury and disease. (C) 2009 Elsevier Ltd. All rights reserved
AB - The complement system is implicated in Wallerian degeneration (WD). We have previously shown that the membrane attack complex (MAC) the terminal activation product of the complement cascade, mediates rapid axonal degradation and myelin clearance during WD after peripheral nerve injury. In this study we analyzed the contribution of CD59a, a cell membrane negative regulator of the MAC, to WD. Following injury, the level of MAC deposition was higher in the CD59a deficient mice than wildtypes whereas the residual axonal content was lower in CD59a deficient mice than wildtypes, strongly implicating MAC as a determinant of axonal damage during WD. The number of endoneurial macrophages was significantly higher in CD59a deficient mice compared to wildtypes at 1 day post-injury. These findings are relevant to the understanding of the mechanisms of axon loss in injury and disease. (C) 2009 Elsevier Ltd. All rights reserved
U2 - https://doi.org/10.1016/j.molimm.2009.01.017
DO - https://doi.org/10.1016/j.molimm.2009.01.017
M3 - Article
C2 - 19246097
SN - 0161-5890
VL - 46
SP - 1892
EP - 1896
JO - Molecular immunology
JF - Molecular immunology
IS - 8-9
ER -