Delayed Microbial Cure of Lymphogranuloma Venereum Proctitis with Doxycycline Treatment

H.J.C. de Vries; V. Smelov; J.G. Middelburg; J. Pleijster; A.G. Speksnijder; S.A. Morré

doi:https://doi.org/10.1086/597011

Delayed Microbial Cure of Lymphogranuloma Venereum Proctitis with Doxycycline Treatment

H.J.C. de Vries, V. Smelov, J.G. Middelburg, J. Pleijster, A.G. Speksnijder, S.A. Morré

Research output: Contribution to journal › Article › Academic › peer-review

66 Citations (Scopus)

Abstract

Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens. In LGV proctitis, RNA persisted for up to 16 days. In non-LGV chlamydia proctitis, DNA was undetectable after 7 days. These findings support the Centers for Disease Control and Prevention's treatment recommendation of a 21-day doxycycline regimen for LGV proctitis and a 7-day regimen for non-LGV chlamydia proctitis. Delayed microbial cure of LGV proctitis should be considered in improved treatment regimens

Original language	Undefined/Unknown
Pages (from-to)	E53-E56
Journal	Clinical Infectious Diseases
Volume	48
Issue number	5
DOIs	https://doi.org/10.1086/597011
Publication status	Published - 2009

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https://doi.org/10.1086/597011

Cite this

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title = "Delayed Microbial Cure of Lymphogranuloma Venereum Proctitis with Doxycycline Treatment",

abstract = "Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens. In LGV proctitis, RNA persisted for up to 16 days. In non-LGV chlamydia proctitis, DNA was undetectable after 7 days. These findings support the Centers for Disease Control and Prevention's treatment recommendation of a 21-day doxycycline regimen for LGV proctitis and a 7-day regimen for non-LGV chlamydia proctitis. Delayed microbial cure of LGV proctitis should be considered in improved treatment regimens",

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T1 - Delayed Microbial Cure of Lymphogranuloma Venereum Proctitis with Doxycycline Treatment

AU - de Vries, H.J.C.

AU - Smelov, V.

AU - Middelburg, J.G.

AU - Pleijster, J.

AU - Speksnijder, A.G.

AU - Morré, S.A.

PY - 2009

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N2 - Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens. In LGV proctitis, RNA persisted for up to 16 days. In non-LGV chlamydia proctitis, DNA was undetectable after 7 days. These findings support the Centers for Disease Control and Prevention's treatment recommendation of a 21-day doxycycline regimen for LGV proctitis and a 7-day regimen for non-LGV chlamydia proctitis. Delayed microbial cure of LGV proctitis should be considered in improved treatment regimens

AB - Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens. In LGV proctitis, RNA persisted for up to 16 days. In non-LGV chlamydia proctitis, DNA was undetectable after 7 days. These findings support the Centers for Disease Control and Prevention's treatment recommendation of a 21-day doxycycline regimen for LGV proctitis and a 7-day regimen for non-LGV chlamydia proctitis. Delayed microbial cure of LGV proctitis should be considered in improved treatment regimens

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DO - https://doi.org/10.1086/597011

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