Delineation of chondroid lipoma: an immunohistochemical and molecular biological analysis

Ronald S A de Vreeze; Frits van Coevorden; Lucie Boerrigter; Petra M Nederlof; Rick L Haas; Johannes Bras; Andreas Rosenwald; Thomas Mentzel; Daphne de Jong

doi:https://doi.org/10.1155/2011/638403

Delineation of chondroid lipoma: an immunohistochemical and molecular biological analysis

Ronald S A de Vreeze, Frits van Coevorden, Lucie Boerrigter, Petra M Nederlof, Rick L Haas, Johannes Bras, Andreas Rosenwald, Thomas Mentzel, Daphne de Jong

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Abstract

Aims. Chondroid lipoma (CL) is a benign tumor that mimics a variety of soft tissue tumors and is characterized by translocation t(11;16). Here, we analyze CL and its histological mimics. Methods. CL (n = 4) was compared to a variety of histological mimics (n = 83) for morphological aspects and immunohistochemical features including cyclinD1(CCND1). Using FISH analysis, CCND1 and FUS were investigated as potential translocation partners. Results. All CLs were strongly positive for CCND1. One of 4 myoepitheliomas, CCND1, was positive. In well-differentiated lipomatous tumors and in chondrosarcomas, CCND1 was frequently expressed, but all myxoid liposarcomas were negative. FISH analysis did not give support for direct involvement of CCND1 and FUS as translocation partners. Conclusions. Chondroid lipoma is extremely rare and has several and more prevalent histological mimics. The differential diagnosis of chondroid lipomas can be unraveled using immunohistochemical and molecular support.

Original language	English
Pages (from-to)	638403
Journal	SARCOMA
Volume	2011
DOIs	https://doi.org/10.1155/2011/638403
Publication status	Published - 2011

Keywords

Journal Article

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https://doi.org/10.1155/2011/638403

Cite this

@article{dfbfca2e11a14a23b7364764c5c08563,

title = "Delineation of chondroid lipoma: an immunohistochemical and molecular biological analysis",

abstract = "Aims. Chondroid lipoma (CL) is a benign tumor that mimics a variety of soft tissue tumors and is characterized by translocation t(11;16). Here, we analyze CL and its histological mimics. Methods. CL (n = 4) was compared to a variety of histological mimics (n = 83) for morphological aspects and immunohistochemical features including cyclinD1(CCND1). Using FISH analysis, CCND1 and FUS were investigated as potential translocation partners. Results. All CLs were strongly positive for CCND1. One of 4 myoepitheliomas, CCND1, was positive. In well-differentiated lipomatous tumors and in chondrosarcomas, CCND1 was frequently expressed, but all myxoid liposarcomas were negative. FISH analysis did not give support for direct involvement of CCND1 and FUS as translocation partners. Conclusions. Chondroid lipoma is extremely rare and has several and more prevalent histological mimics. The differential diagnosis of chondroid lipomas can be unraveled using immunohistochemical and molecular support.",

keywords = "Journal Article",

author = "{de Vreeze}, {Ronald S A} and {van Coevorden}, Frits and Lucie Boerrigter and Nederlof, {Petra M} and Haas, {Rick L} and Johannes Bras and Andreas Rosenwald and Thomas Mentzel and {de Jong}, Daphne",

year = "2011",

doi = "https://doi.org/10.1155/2011/638403",

language = "English",

volume = "2011",

pages = "638403",

journal = "SARCOMA",

issn = "1357-714X",

publisher = "Hindawi Publishing Corporation",

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TY - JOUR

T1 - Delineation of chondroid lipoma

T2 - an immunohistochemical and molecular biological analysis

AU - de Vreeze, Ronald S A

AU - van Coevorden, Frits

AU - Boerrigter, Lucie

AU - Nederlof, Petra M

AU - Haas, Rick L

AU - Bras, Johannes

AU - Rosenwald, Andreas

AU - Mentzel, Thomas

AU - de Jong, Daphne

PY - 2011

Y1 - 2011

N2 - Aims. Chondroid lipoma (CL) is a benign tumor that mimics a variety of soft tissue tumors and is characterized by translocation t(11;16). Here, we analyze CL and its histological mimics. Methods. CL (n = 4) was compared to a variety of histological mimics (n = 83) for morphological aspects and immunohistochemical features including cyclinD1(CCND1). Using FISH analysis, CCND1 and FUS were investigated as potential translocation partners. Results. All CLs were strongly positive for CCND1. One of 4 myoepitheliomas, CCND1, was positive. In well-differentiated lipomatous tumors and in chondrosarcomas, CCND1 was frequently expressed, but all myxoid liposarcomas were negative. FISH analysis did not give support for direct involvement of CCND1 and FUS as translocation partners. Conclusions. Chondroid lipoma is extremely rare and has several and more prevalent histological mimics. The differential diagnosis of chondroid lipomas can be unraveled using immunohistochemical and molecular support.

AB - Aims. Chondroid lipoma (CL) is a benign tumor that mimics a variety of soft tissue tumors and is characterized by translocation t(11;16). Here, we analyze CL and its histological mimics. Methods. CL (n = 4) was compared to a variety of histological mimics (n = 83) for morphological aspects and immunohistochemical features including cyclinD1(CCND1). Using FISH analysis, CCND1 and FUS were investigated as potential translocation partners. Results. All CLs were strongly positive for CCND1. One of 4 myoepitheliomas, CCND1, was positive. In well-differentiated lipomatous tumors and in chondrosarcomas, CCND1 was frequently expressed, but all myxoid liposarcomas were negative. FISH analysis did not give support for direct involvement of CCND1 and FUS as translocation partners. Conclusions. Chondroid lipoma is extremely rare and has several and more prevalent histological mimics. The differential diagnosis of chondroid lipomas can be unraveled using immunohistochemical and molecular support.

KW - Journal Article

U2 - https://doi.org/10.1155/2011/638403

DO - https://doi.org/10.1155/2011/638403

M3 - Article

C2 - 21559269

SN - 1357-714X

VL - 2011

SP - 638403

JO - SARCOMA

JF - SARCOMA

ER -