Dendritic cell-based vaccines: from mouse models to clinical cancer immunotherapy

M. W. Schreurs; A. A. Eggert; C. J. Punt; C. G. Figdor; G. J. Adema

Dendritic cell-based vaccines: from mouse models to clinical cancer immunotherapy

M. W. Schreurs, A. A. Eggert, C. J. Punt, C. G. Figdor, G. J. Adema

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Research output: Contribution to journal › Review article › Academic › peer-review

38 Citations (Scopus)

Abstract

B and T lymphocytes are the effectors of specific immunity. However, their function is critically dependent on dendritic cells (DC). DC are professional antigen presenting cells that both initiate and modulate the immune response. The recent breakthrough in the generation of DC from their progenitors has stimulated research on DC in both fundamental and clinical immunology. Objective immune response induction has now been reported in clinical studies using DC. In this review we discuss the development and potential of DC-based vaccines to induce antitumor immunity

Original language	English
Pages (from-to)	1-17
Journal	Critical reviews in oncogenesis
Volume	11
Issue number	1
Publication status	Published - 2000

Cite this

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title = "Dendritic cell-based vaccines: from mouse models to clinical cancer immunotherapy",

abstract = "B and T lymphocytes are the effectors of specific immunity. However, their function is critically dependent on dendritic cells (DC). DC are professional antigen presenting cells that both initiate and modulate the immune response. The recent breakthrough in the generation of DC from their progenitors has stimulated research on DC in both fundamental and clinical immunology. Objective immune response induction has now been reported in clinical studies using DC. In this review we discuss the development and potential of DC-based vaccines to induce antitumor immunity",

author = "Schreurs, {M. W.} and Eggert, {A. A.} and Punt, {C. J.} and Figdor, {C. G.} and Adema, {G. J.}",

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AU - Schreurs, M. W.

AU - Eggert, A. A.

AU - Punt, C. J.

AU - Figdor, C. G.

AU - Adema, G. J.

PY - 2000

Y1 - 2000

N2 - B and T lymphocytes are the effectors of specific immunity. However, their function is critically dependent on dendritic cells (DC). DC are professional antigen presenting cells that both initiate and modulate the immune response. The recent breakthrough in the generation of DC from their progenitors has stimulated research on DC in both fundamental and clinical immunology. Objective immune response induction has now been reported in clinical studies using DC. In this review we discuss the development and potential of DC-based vaccines to induce antitumor immunity

AB - B and T lymphocytes are the effectors of specific immunity. However, their function is critically dependent on dendritic cells (DC). DC are professional antigen presenting cells that both initiate and modulate the immune response. The recent breakthrough in the generation of DC from their progenitors has stimulated research on DC in both fundamental and clinical immunology. Objective immune response induction has now been reported in clinical studies using DC. In this review we discuss the development and potential of DC-based vaccines to induce antitumor immunity

M3 - Review article

C2 - 10795625

SN - 0893-9675

VL - 11

SP - 1

EP - 17

JO - Critical reviews in oncogenesis

JF - Critical reviews in oncogenesis

IS - 1

ER -