TY - JOUR
T1 - Depressive symptoms as risk factor of cardiovascular mortality in older European men
T2 - The Finland, Italy and Netherlands Elderly (FINE) study
AU - Kamphuis, Marjolein H.
AU - Kalmijn, Sandra
AU - Tijhuis, Marja A. R.
AU - Geerlings, Mirjam I.
AU - Giampaoli, Simona
AU - Nissinen, Aulikki
AU - Grobbee, Diederick E.
AU - Kromhout, Daan
PY - 2006
Y1 - 2006
N2 - Depressive symptoms have been suggested to increase the risk of cardiovascular diseases, but this may reflect reversed causality. We investigated to what extent depressive symptoms are a true risk factor for cardiovascular mortality in elderly men. The Finland, Italy and Netherlands Elderly (FINE) study is a prospective cohort study conducted in Finland, Italy and The Netherlands. Depressive symptoms were measured with the Zung self-rating Depression Scale in 799 elderly men, aged 70–90 years, free from cardiovascular diseases. Using Cox models, hazard ratios (HRs) were calculated for specific cardiovascular mortality endpoints. The analyses were adjusted for potential confounders, stratified on country and repeated after exclusion of men who died from cardiovascular diseases up to 5 years after baseline. During 10-years of follow-up 224 (28%) men died from cardiovascular diseases. The adjusted hazard for a five-point increase in depressive symptoms was 1.15 [95% confidence interval (CI) 1.08–1.23] for cardiovascular mortality. This risk was stronger for mortality from stroke (HR 1.35; 95% CI 1.19–1.53) and heart failure (HR 1.16; 95% CI 1.00–1.35) in comparison with mortality from coronary heart disease (HR 1.08; 95% CI 0.97–1.20) and other degenerative heart diseases (HR 1.06; 95% CI 0.91–1.23). Exclusion of men who died from cardiovascular diseases within 5 years after baseline did not change the strength of the associations. There were no significant differences in HRs between northern and southern Europe. This study provides further and more convincing prospective evidence for depressive symptoms as a risk factor for cardiovascular mortality in elderly men. © 2006, European Society of Cardiology. All rights reserved.
AB - Depressive symptoms have been suggested to increase the risk of cardiovascular diseases, but this may reflect reversed causality. We investigated to what extent depressive symptoms are a true risk factor for cardiovascular mortality in elderly men. The Finland, Italy and Netherlands Elderly (FINE) study is a prospective cohort study conducted in Finland, Italy and The Netherlands. Depressive symptoms were measured with the Zung self-rating Depression Scale in 799 elderly men, aged 70–90 years, free from cardiovascular diseases. Using Cox models, hazard ratios (HRs) were calculated for specific cardiovascular mortality endpoints. The analyses were adjusted for potential confounders, stratified on country and repeated after exclusion of men who died from cardiovascular diseases up to 5 years after baseline. During 10-years of follow-up 224 (28%) men died from cardiovascular diseases. The adjusted hazard for a five-point increase in depressive symptoms was 1.15 [95% confidence interval (CI) 1.08–1.23] for cardiovascular mortality. This risk was stronger for mortality from stroke (HR 1.35; 95% CI 1.19–1.53) and heart failure (HR 1.16; 95% CI 1.00–1.35) in comparison with mortality from coronary heart disease (HR 1.08; 95% CI 0.97–1.20) and other degenerative heart diseases (HR 1.06; 95% CI 0.91–1.23). Exclusion of men who died from cardiovascular diseases within 5 years after baseline did not change the strength of the associations. There were no significant differences in HRs between northern and southern Europe. This study provides further and more convincing prospective evidence for depressive symptoms as a risk factor for cardiovascular mortality in elderly men. © 2006, European Society of Cardiology. All rights reserved.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33746254112&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/16575273
U2 - https://doi.org/10.1097/01.hjr.0000188242.64590.92
DO - https://doi.org/10.1097/01.hjr.0000188242.64590.92
M3 - Article
C2 - 16575273
SN - 2047-4873
VL - 13
SP - 199
EP - 206
JO - European journal of preventive cardiology
JF - European journal of preventive cardiology
IS - 2
ER -