TY - JOUR
T1 - Derangements of intravascular remodeling of lipoproteins in type 2 diabetes mellitus: consequences for atherosclerosis development
AU - Dallinga-Thie, Geesje M.
AU - Dullaart, Robin P. F.
AU - van Tol, Arie
PY - 2008
Y1 - 2008
N2 - In type 2 diabetes mellitus, elevated fasting and postprandial plasma triglycerides, small dense low-density lipoprotein particles, low high-density lipoprotein (HDL) cholesterol levels, and increased action of lipid transfer proteins may enhance peripheral lipid accumulation and increase cardiovascular risk. Despite low HDL cholesterol, plasma's ability to stimulate cellular cholesterol efflux, reflecting an early step in the reverse cholesterol transport pathway, appears to be maintained, perhaps implicating a compensatory mechanism
AB - In type 2 diabetes mellitus, elevated fasting and postprandial plasma triglycerides, small dense low-density lipoprotein particles, low high-density lipoprotein (HDL) cholesterol levels, and increased action of lipid transfer proteins may enhance peripheral lipid accumulation and increase cardiovascular risk. Despite low HDL cholesterol, plasma's ability to stimulate cellular cholesterol efflux, reflecting an early step in the reverse cholesterol transport pathway, appears to be maintained, perhaps implicating a compensatory mechanism
U2 - https://doi.org/10.1007/s11892-008-0012-3
DO - https://doi.org/10.1007/s11892-008-0012-3
M3 - Article
C2 - 18367001
SN - 1534-4827
VL - 8
SP - 65
EP - 70
JO - Current Diabetes Reports
JF - Current Diabetes Reports
IS - 1
ER -