Detecting resistance in EGFR-mutated non-small-cell lung cancer after clonal selection through targeted therapy

J.L. Kuiper, I. Bahce, C. Voorhoeve, M. Yaqub, D.A.M. Heideman, E. Thunnissen, M.A. Paul, P.E. Postmus, N.H. Hendrikse, E.F. Smit

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Tumor heterogeneity plays an important role in the development of treatment-resistance, especially in the current era of targeted therapies. Although tumor heterogeneity is a widely recognized phenomenon, it is at present unclear how this knowledge should be incorporated into daily clinical practice. In this report, we describe an innovative nuclear imaging method that may play a role in detecting tumor heterogeneity in the future.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalPersonalized Medicine
Issue number2
Publication statusPublished - Mar 2015

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