TY - JOUR
T1 - Detection and size quantification of pulmonary nodules in ultralow-dose versus regular-dose CT
T2 - a comparative study in COPD patients
AU - Han, Daiwei
AU - Cai, Jiali
AU - Heus, Anne
AU - Heuvelmans, Marjolein
AU - Imkamp, Kai
AU - Dorrius, Monique
AU - Pelgrim, Gert-Jan
AU - DE JONGE, Gonda
AU - Oudkerk, Matthijs
AU - VAN DEN BERGE, Maarten
AU - Vliegenthart, Rozemarijn
N1 - Funding Information: Rozemarijn Vliegenthart is supported by an institutional research grant from Siemens Healthineers. For the remaining authors none were declared. Publisher Copyright: © 2023 The Authors.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Objective: To evaluate detectability and semi-automatic diameter and volume measurements of pulmonary nodules in ultralow-dose CT (ULDCT) vs regular-dose CT (RDCT). Methods: Fifty patients with chronic obstructive pulmonary disease (COPD) underwent RDCT on 64-multidetector CT (120 kV, filtered back projection), and ULDCT on third-generation dual source CT (100 kV with tin filter, advanced modeled iterative reconstruction). One radiologist evaluated the presence of nodules on both scans in random order, with discrepancies judged by two independent radiologists and consensus reading. Sensitivity of nodule detection on RDCT and ULDCT was compared to reader consensus. Systematic error in semi-automatically derived diameter and volume, and 95% limits of agreement (LoA) were evaluated. Nodule classification was compared by κ statistics. Results: ULDCT resulted in 83.1% (95% CI: 81.0–85.2) dose reduction compared to RDCT (p < 0.001). 45 nodules were present, with diameter range 4.0–25.3 mm and volume range 16.0–4483.0 mm 3. Detection sensitivity was non-significant (p = 0.503) between RDCT 88.8% (95% CI: 76.0–96.3) and ULDCT 95.5% (95% CI: 84.9– 99.5). No systematic bias in diameter measurements (median difference: −0.2 mm) or volumetry (median difference: −6 mm 3) was found for ULDCT compared to RDCT. The 95% LoA for diameter and volume measurements were ±3.0 mm and ±33.5%, respectively. κ value for nodule classification was 0.852 for diameter measurements and 0.930 for volumetry. Conclusion: ULDCT based on Sn100 kV enables comparable detectability of solid pulmonary nodules in COPD patients, at 83% reduced radiation dose compared to RDCT, without relevant difference in nodule measurement and size classification. Advances in knowledge: Pulmonary nodule detectability and measurements in ULDCT are comparable to RDCT.
AB - Objective: To evaluate detectability and semi-automatic diameter and volume measurements of pulmonary nodules in ultralow-dose CT (ULDCT) vs regular-dose CT (RDCT). Methods: Fifty patients with chronic obstructive pulmonary disease (COPD) underwent RDCT on 64-multidetector CT (120 kV, filtered back projection), and ULDCT on third-generation dual source CT (100 kV with tin filter, advanced modeled iterative reconstruction). One radiologist evaluated the presence of nodules on both scans in random order, with discrepancies judged by two independent radiologists and consensus reading. Sensitivity of nodule detection on RDCT and ULDCT was compared to reader consensus. Systematic error in semi-automatically derived diameter and volume, and 95% limits of agreement (LoA) were evaluated. Nodule classification was compared by κ statistics. Results: ULDCT resulted in 83.1% (95% CI: 81.0–85.2) dose reduction compared to RDCT (p < 0.001). 45 nodules were present, with diameter range 4.0–25.3 mm and volume range 16.0–4483.0 mm 3. Detection sensitivity was non-significant (p = 0.503) between RDCT 88.8% (95% CI: 76.0–96.3) and ULDCT 95.5% (95% CI: 84.9– 99.5). No systematic bias in diameter measurements (median difference: −0.2 mm) or volumetry (median difference: −6 mm 3) was found for ULDCT compared to RDCT. The 95% LoA for diameter and volume measurements were ±3.0 mm and ±33.5%, respectively. κ value for nodule classification was 0.852 for diameter measurements and 0.930 for volumetry. Conclusion: ULDCT based on Sn100 kV enables comparable detectability of solid pulmonary nodules in COPD patients, at 83% reduced radiation dose compared to RDCT, without relevant difference in nodule measurement and size classification. Advances in knowledge: Pulmonary nodule detectability and measurements in ULDCT are comparable to RDCT.
UR - http://www.scopus.com/inward/record.url?scp=85150751232&partnerID=8YFLogxK
U2 - https://doi.org/10.1259/bjr.20220709
DO - https://doi.org/10.1259/bjr.20220709
M3 - Article
C2 - 36728829
SN - 0007-1285
VL - 96
JO - British journal of radiology
JF - British journal of radiology
IS - 1144
M1 - 20220709
ER -