Detection of phase I IgG antibodies to Coxiella burnetii with EIA as a screening test for blood donations

W. van der Hoek; C. C. H. Wielders; B. Schimmer; M. C. A. Wegdam-Blans; J. Meekelenkamp; H. L. Zaaijer; P. M. Schneeberger

doi:https://doi.org/10.1007/s10096-012-1686-7

Detection of phase I IgG antibodies to Coxiella burnetii with EIA as a screening test for blood donations

W. van der Hoek, C. C. H. Wielders, B. Schimmer, M. C. A. Wegdam-Blans, J. Meekelenkamp, H. L. Zaaijer, P. M. Schneeberger

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

The presence of a high phase I IgG antibody titre may indicate chronic infection and a risk for the transmission of Coxiella burnetii through blood transfusion. The outbreak of Q fever in the Netherlands allowed for the comparison of an enzyme immunoassay (EIA) with the reference immunofluorescence assay (IFA) in a large group of individuals one year after acute Q fever. EIA is 100 % sensitive in detecting high (a parts per thousand yen1:1,024) phase I IgG antibody titres. The cost of screening with EIA and confirming all EIA-positive results with IFA is much lower than screening all donations with IFA. This should be taken into account in cost-effectiveness analyses of screening programmes

Original language	English
Pages (from-to)	3207-3209
Journal	European journal of clinical microbiology & infectious diseases
Volume	31
Issue number	11
DOIs	https://doi.org/10.1007/s10096-012-1686-7
Publication status	Published - 2012

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https://doi.org/10.1007/s10096-012-1686-7

Cite this

van der Hoek, W., Wielders, C. C. H., Schimmer, B., Wegdam-Blans, M. C. A., Meekelenkamp, J., Zaaijer, H. L., & Schneeberger, P. M. (2012). Detection of phase I IgG antibodies to Coxiella burnetii with EIA as a screening test for blood donations. European journal of clinical microbiology & infectious diseases, 31(11), 3207-3209. https://doi.org/10.1007/s10096-012-1686-7

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abstract = "The presence of a high phase I IgG antibody titre may indicate chronic infection and a risk for the transmission of Coxiella burnetii through blood transfusion. The outbreak of Q fever in the Netherlands allowed for the comparison of an enzyme immunoassay (EIA) with the reference immunofluorescence assay (IFA) in a large group of individuals one year after acute Q fever. EIA is 100 % sensitive in detecting high (a parts per thousand yen1:1,024) phase I IgG antibody titres. The cost of screening with EIA and confirming all EIA-positive results with IFA is much lower than screening all donations with IFA. This should be taken into account in cost-effectiveness analyses of screening programmes",

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AU - Wielders, C. C. H.

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AU - Wegdam-Blans, M. C. A.

AU - Meekelenkamp, J.

AU - Zaaijer, H. L.

AU - Schneeberger, P. M.

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