TY - JOUR
T1 - Detection of unknown primary tumours and distant metastases in patients with cervical metastases
T2 - Value of FDG-PET versus conventional modalities
AU - Regelink, Gerreke
AU - Brouwer, Jolijn
AU - De Bree, Remco
AU - Pruim, Jan
AU - Van Der Laan, Bernard F.
AU - Vaalburg, Willem
AU - Hoekstra, Otto S.
AU - Comans, Emile F.
AU - Vissink, Arjan
AU - Leemans, René C.
AU - Roodenburg, Jan L.
PY - 2002
Y1 - 2002
N2 - In 1%-2% of head and neck oncology patients, the only symptom of a malignancy is a positive cervical node. The aim of this study was to compare the value of positron emission tomography using fluorine-18 fluoro-2-deoxy-D-glucose (FDG-PET) and conventional diagnostic modalities (CT and/or MRI, panendoscopy) in detecting unknown primary tumours and distant metastases in patients suffering from such a cervical metastasis. Fifty patients (37 men and 13 women) with cervical metastases of an unknown primary tumour were included. All patients underwent FDG-PET. In addition, CT and/or MRI was obtained and panendoscopy was performed. All clinically known metastases were detected by FDG-PET. The primary tumour could be diagnosed in 16 patients (four primary tumours were detected exclusively by FDG-PET). Seven patients had multiple distant metastases, that in six cases were detected exclusively by FDG-PET. The sensitivity and specificity of FDG-PET for detection of unknown primary tumours were 100% and 94%, respectively. For the conventional diagnostic modalities these values were 92% and 76%. FDG-PET had an exclusive effect on the applied therapy in 20% of the patients referred for diagnosis of an unknown primary tumour. The data obtained in this study strongly support the diagnostic strategy of performing FDG-PET in patients suffering from cervical metastases of an unknown primary tumour before any other diagnostic technique.
AB - In 1%-2% of head and neck oncology patients, the only symptom of a malignancy is a positive cervical node. The aim of this study was to compare the value of positron emission tomography using fluorine-18 fluoro-2-deoxy-D-glucose (FDG-PET) and conventional diagnostic modalities (CT and/or MRI, panendoscopy) in detecting unknown primary tumours and distant metastases in patients suffering from such a cervical metastasis. Fifty patients (37 men and 13 women) with cervical metastases of an unknown primary tumour were included. All patients underwent FDG-PET. In addition, CT and/or MRI was obtained and panendoscopy was performed. All clinically known metastases were detected by FDG-PET. The primary tumour could be diagnosed in 16 patients (four primary tumours were detected exclusively by FDG-PET). Seven patients had multiple distant metastases, that in six cases were detected exclusively by FDG-PET. The sensitivity and specificity of FDG-PET for detection of unknown primary tumours were 100% and 94%, respectively. For the conventional diagnostic modalities these values were 92% and 76%. FDG-PET had an exclusive effect on the applied therapy in 20% of the patients referred for diagnosis of an unknown primary tumour. The data obtained in this study strongly support the diagnostic strategy of performing FDG-PET in patients suffering from cervical metastases of an unknown primary tumour before any other diagnostic technique.
KW - Conventional imaging techniques
KW - F-Fluoro-2-deoxy-D-glucose
KW - Head and neck cancer
KW - Positron emission tomography
KW - Unknown primary tumour
UR - http://www.scopus.com/inward/record.url?scp=0036688804&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00259-002-0819-0
DO - https://doi.org/10.1007/s00259-002-0819-0
M3 - Article
C2 - 12173016
SN - 0340-6997
VL - 29
SP - 1024
EP - 1030
JO - European journal of nuclear medicine
JF - European journal of nuclear medicine
IS - 8
ER -