Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy

P. Knaapen, T. Germans, P.G. Camici, O.E. Rimoldi, F.J. ten Cate, J.M. ten Berg, P.A. Dijkmans, R. Boellaard, W.G. van Dockum, M.J.W. Gotte, J.W.R. Twisk, A.C. van Rossum, A.A. Lammertsma, F.C. Visser

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Impaired hyperemic myocardial blood flow (MBF) in hypertrophic cardiomyopathy (HCM), despite normal epicardial coronary arteries, results in microvascular dysfunction. The aim of the present study was to determine the relative contribution of extravascular compressive forces to microvascular dysfunction in HCM. Eighteen patients with symptomatic HCM and normal coronary arteries and 10 age-matched healthy volunteers were studied with PET to quantify resting and hyperemic MBF at a subendocardial and subepicardial level. In HCM patients, MRI was performed to determine left ventricular (LV) mass index (LVMI) and volumes, echocardiography to assess diastolic perfusion time, heart catheterization to measure LV outflow tract gradient (LVOTG) and LV pressures, and serum NH
Original languageEnglish
Pages (from-to)H986-H993
JournalAmerican journal of physiology. Heart and circulatory physiology
Issue number2
Publication statusPublished - 2008

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