Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy

P. Knaapen; T. Germans; P.G. Camici; O.E. Rimoldi; F.J. ten Cate; J.M. ten Berg; P.A. Dijkmans; R. Boellaard; W.G. van Dockum; M.J.W. Gotte; J.W.R. Twisk; A.C. van Rossum; A.A. Lammertsma; F.C. Visser

doi:https://doi.org/10.1152/ajpheart.00233.2007

Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy

P. Knaapen, T. Germans, P.G. Camici, O.E. Rimoldi, F.J. ten Cate, J.M. ten Berg, P.A. Dijkmans, R. Boellaard, W.G. van Dockum, M.J.W. Gotte, J.W.R. Twisk, A.C. van Rossum, A.A. Lammertsma, F.C. Visser

Research output: Contribution to journal › Article › Academic › peer-review

108 Citations (Scopus)

Abstract

Impaired hyperemic myocardial blood flow (MBF) in hypertrophic cardiomyopathy (HCM), despite normal epicardial coronary arteries, results in microvascular dysfunction. The aim of the present study was to determine the relative contribution of extravascular compressive forces to microvascular dysfunction in HCM. Eighteen patients with symptomatic HCM and normal coronary arteries and 10 age-matched healthy volunteers were studied with PET to quantify resting and hyperemic MBF at a subendocardial and subepicardial level. In HCM patients, MRI was performed to determine left ventricular (LV) mass index (LVMI) and volumes, echocardiography to assess diastolic perfusion time, heart catheterization to measure LV outflow tract gradient (LVOTG) and LV pressures, and serum NH

Original language	English
Pages (from-to)	H986-H993
Journal	American journal of physiology. Heart and circulatory physiology
Volume	294
Issue number	2
DOIs	https://doi.org/10.1152/ajpheart.00233.2007
Publication status	Published - 2008

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Cite this

Knaapen, P., Germans, T., Camici, P. G., Rimoldi, O. E., ten Cate, F. J., ten Berg, J. M., Dijkmans, P. A., Boellaard, R., van Dockum, W. G., Gotte, M. J. W., Twisk, J. W. R., van Rossum, A. C., Lammertsma, A. A., & Visser, F. C. (2008). Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy. American journal of physiology. Heart and circulatory physiology, 294(2), H986-H993. https://doi.org/10.1152/ajpheart.00233.2007

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title = "Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy",

abstract = "Impaired hyperemic myocardial blood flow (MBF) in hypertrophic cardiomyopathy (HCM), despite normal epicardial coronary arteries, results in microvascular dysfunction. The aim of the present study was to determine the relative contribution of extravascular compressive forces to microvascular dysfunction in HCM. Eighteen patients with symptomatic HCM and normal coronary arteries and 10 age-matched healthy volunteers were studied with PET to quantify resting and hyperemic MBF at a subendocardial and subepicardial level. In HCM patients, MRI was performed to determine left ventricular (LV) mass index (LVMI) and volumes, echocardiography to assess diastolic perfusion time, heart catheterization to measure LV outflow tract gradient (LVOTG) and LV pressures, and serum NH",

author = "P. Knaapen and T. Germans and P.G. Camici and O.E. Rimoldi and {ten Cate}, F.J. and {ten Berg}, J.M. and P.A. Dijkmans and R. Boellaard and {van Dockum}, W.G. and M.J.W. Gotte and J.W.R. Twisk and {van Rossum}, A.C. and A.A. Lammertsma and F.C. Visser",

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Knaapen, P , Germans, T, Camici, PG, Rimoldi, OE, ten Cate, FJ, ten Berg, JM, Dijkmans, PA, Boellaard, R, van Dockum, WG, Gotte, MJW , Twisk, JWR , van Rossum, AC , Lammertsma, AA & Visser, FC 2008, 'Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy', American journal of physiology. Heart and circulatory physiology, vol. 294, no. 2, pp. H986-H993. https://doi.org/10.1152/ajpheart.00233.2007

TY - JOUR

T1 - Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy

AU - Knaapen, P.

AU - Germans, T.

AU - Camici, P.G.

AU - Rimoldi, O.E.

AU - ten Cate, F.J.

AU - ten Berg, J.M.

AU - Dijkmans, P.A.

AU - Boellaard, R.

AU - van Dockum, W.G.

AU - Gotte, M.J.W.

AU - Twisk, J.W.R.

AU - van Rossum, A.C.

AU - Lammertsma, A.A.

AU - Visser, F.C.

PY - 2008

Y1 - 2008

N2 - Impaired hyperemic myocardial blood flow (MBF) in hypertrophic cardiomyopathy (HCM), despite normal epicardial coronary arteries, results in microvascular dysfunction. The aim of the present study was to determine the relative contribution of extravascular compressive forces to microvascular dysfunction in HCM. Eighteen patients with symptomatic HCM and normal coronary arteries and 10 age-matched healthy volunteers were studied with PET to quantify resting and hyperemic MBF at a subendocardial and subepicardial level. In HCM patients, MRI was performed to determine left ventricular (LV) mass index (LVMI) and volumes, echocardiography to assess diastolic perfusion time, heart catheterization to measure LV outflow tract gradient (LVOTG) and LV pressures, and serum NH

AB - Impaired hyperemic myocardial blood flow (MBF) in hypertrophic cardiomyopathy (HCM), despite normal epicardial coronary arteries, results in microvascular dysfunction. The aim of the present study was to determine the relative contribution of extravascular compressive forces to microvascular dysfunction in HCM. Eighteen patients with symptomatic HCM and normal coronary arteries and 10 age-matched healthy volunteers were studied with PET to quantify resting and hyperemic MBF at a subendocardial and subepicardial level. In HCM patients, MRI was performed to determine left ventricular (LV) mass index (LVMI) and volumes, echocardiography to assess diastolic perfusion time, heart catheterization to measure LV outflow tract gradient (LVOTG) and LV pressures, and serum NH

U2 - https://doi.org/10.1152/ajpheart.00233.2007

DO - https://doi.org/10.1152/ajpheart.00233.2007

M3 - Article

C2 - 18156203

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JO - American journal of physiology. Heart and circulatory physiology

JF - American journal of physiology. Heart and circulatory physiology

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