Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis

Karel C. Smit; Jeroen W. G. Derksen; Rebecca K. Stellato; Anne-Sophie van Lanen; Evertine Wesselink; Eric J. T. H. Belt; Marissa Cloos-Van Balen; Peter Paul L. O. Coene; Jan Willem T. Dekker; Jan Willem de Groot; Annebeth W. Haringhuizen; Henk K. van Halteren; Tjarda T. van Heek; Helgi H. Helgason; Mathijs P. Hendriks; Ignace H. J. T. de Hingh; Ronald Hoekstra; Danny Houtsma; Johan J. B. Janssen; K. O. K. Niels; Joop L. M. Konsten; Maartje Los; Martijn R. Meijerink; Leonie J. M. Mekenkamp; Koen C. M. J. Peeters; Marco B. Polée; Ron C. Rietbroek; Anandi H. W. Schiphorst; Ruud W. M. Schrauwen; Jennifer Schreinemakers; Mark P. S. Sie; Lieke Simkens; Eric J. A. Sonneveld; Frederiek Terheggen; Liselot Valkenburg-Van Iersel; Wouter J. Vles; Daria K. Wasowicz-Kemps; Johannes H. W. de Wilt; Dieuwertje E. Kok; Renate M. Winkels; Ellen Kampman; Fränzel J. B. van Duijnhoven; Miriam Koopman; Anne M. May

doi:10.1249/MSS.0000000000003351

Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis

Karel C. Smit, Jeroen W. G. Derksen, Rebecca K. Stellato, Anne-Sophie van Lanen, Evertine Wesselink, Eric J. T. H. Belt, Marissa Cloos-Van Balen, Peter Paul L. O. Coene, Jan Willem T. Dekker, Jan Willem de Groot, Annebeth W. Haringhuizen, Henk K. van Halteren, Tjarda T. van Heek, Helgi H. Helgason, Mathijs P. Hendriks, Ignace H. J. T. de Hingh, Ronald Hoekstra, Danny Houtsma, Johan J. B. Janssen, K. O. K. NielsJoop L. M. Konsten, Maartje Los, Martijn R. Meijerink, Leonie J. M. Mekenkamp, Koen C. M. J. Peeters, Marco B. Polée, Ron C. Rietbroek, Anandi H. W. Schiphorst, Ruud W. M. Schrauwen, Jennifer Schreinemakers, Mark P. S. Sie, Lieke Simkens, Eric J. A. Sonneveld, Frederiek Terheggen, Liselot Valkenburg-Van Iersel, Wouter J. Vles, Daria K. Wasowicz-Kemps, Johannes H. W. de Wilt, Dieuwertje E. Kok, Renate M. Winkels, Ellen Kampman, Fränzel J. B. van Duijnhoven, Miriam Koopman, Anne M. May

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

SMIT K. C., J.W.G. DERKSEN, R. K. STELLATO, A.-S. VAN LANEN, E. WESSELINK, E. J. T. BELT,M. C.-V. BALEN, P. P. L. O. COENE, J. W. T. DEKKER, J. W. DE GROOT, A. W. HARINGHUIZEN, H. K. VAN HALTEREN, T. T. VAN HEEK, H. H. HELGASON, M. P. HENDRIKS, I. H. J. T. DE HINGH, R. HOEKSTRA, D. HOUTSMA, J. J. B. JANSSEN, N. KOK, J. L. M. KONSTEN, M. LOS, M. R. MEIJERINK, L. J. M. MEKENKAMP, K. C. M. J. PEETERS, M. B. POLÉE, R. C. RIETBROEK, A. H. W. SCHIPHORST, R. W. M. SCHRAUWEN, J. SCHREINEMAKERS, M. P. S. SIE, L. SIMKENS, E. J. A. SONNEVELD, F. TERHEGGEN, L. V.-V. IERSEL,W. J. VLES, D. K.WASOWICZ-KEMPS, J. H. W. DEWILT, D. E. KOK, R. M.WINKELS, E. KAMPMAN, F. J. B. VAN DUIJNHOVEN, M. KOOPMAN, and A.M. MAY . Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis. Med. Sci. Sports Exerc., Vol. 56, No. 4, pp. 623- 634, 2024. Introduction: Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until 5 yr postdiagnosis. Methods: Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined. Moderate-to-vigorous PA during sport and leisure time (MVPA-SL) was measured at diagnosis (T0) and 6, 12, 24, and 60 months (T6 to T60) postdiagnosis, using the SQUASH questionnaire. Mixed-effects models were performed to identify sociodemographic and disease-related determinants of MVPA-SL, separately for stage I–III colon (CC), stage I–III rectal cancer (RC), and stage IV CRC (T0 and T6 only). Associations were defined as consistently present when significant at ≥4 timepoints for the stage I–III subsets. MVPA-SL levels were compared with an age- and sex-matched sample of the general Dutch population. Results: In total, 2905 CC, 1459 RC and 436 stage IV CRC patients were included. Patients with higher fatigue scores, and women compared with men had consistently lower MVPA-SL levels over time, regardless of tumor type and stage. At T6, having a stoma was significantly associated with lower MVPA-SL among stage I-III RC patients. Systemic therapy and radiotherapy were not significantly associated with MVPA-SL changes at T6. Compared with the general population, MVPA-SL levels of CRC patients were lower at all timepoints, most notably at T6. Conclusions: Female sex and higher fatigue scores were consistent determinants of lower MVPA-SL levels among all CRC patients, and MVPA-SL levels were lowest at 6 months postdiagnosis. Our results can inform the design of intervention studies aimed at improving PA, and guide healthcare professionals in optimizing individualized support.

Original language	English
Pages (from-to)	623-634
Number of pages	12
Journal	Medicine and science in sports and exercise
Volume	56
Issue number	4
DOIs	https://doi.org/10.1249/MSS.0000000000003351
Publication status	Published - 1 Apr 2024

Keywords

COLORECTAL NEOPLASMS
GUIDELINES
HEALTH BEHAVIOR
SPORT PARTICIPATION
SURVIVORSHIP

Access to Document

10.1249/MSS.0000000000003351

Cite this

Smit, K. C., Derksen, J. W. G., Stellato, R. K., van Lanen, A.-S., Wesselink, E., Belt, E. J. T. H., Balen, M. C.-V., Coene, P. P. L. O., Dekker, J. W. T., de Groot, J. W., Haringhuizen, A. W., van Halteren, H. K., van Heek, T. T., Helgason, H. H., Hendriks, M. P., de Hingh, I. H. J. T., Hoekstra, R., Houtsma, D., Janssen, J. J. B., ... May, A. M. (2024). Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis. Medicine and science in sports and exercise, 56(4), 623-634. https://doi.org/10.1249/MSS.0000000000003351

@article{cba24c432d1841ac8b13c13050411b2a,

title = "Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis",

abstract = "SMIT K. C., J.W.G. DERKSEN, R. K. STELLATO, A.-S. VAN LANEN, E. WESSELINK, E. J. T. BELT,M. C.-V. BALEN, P. P. L. O. COENE, J. W. T. DEKKER, J. W. DE GROOT, A. W. HARINGHUIZEN, H. K. VAN HALTEREN, T. T. VAN HEEK, H. H. HELGASON, M. P. HENDRIKS, I. H. J. T. DE HINGH, R. HOEKSTRA, D. HOUTSMA, J. J. B. JANSSEN, N. KOK, J. L. M. KONSTEN, M. LOS, M. R. MEIJERINK, L. J. M. MEKENKAMP, K. C. M. J. PEETERS, M. B. POL{\'E}E, R. C. RIETBROEK, A. H. W. SCHIPHORST, R. W. M. SCHRAUWEN, J. SCHREINEMAKERS, M. P. S. SIE, L. SIMKENS, E. J. A. SONNEVELD, F. TERHEGGEN, L. V.-V. IERSEL,W. J. VLES, D. K.WASOWICZ-KEMPS, J. H. W. DEWILT, D. E. KOK, R. M.WINKELS, E. KAMPMAN, F. J. B. VAN DUIJNHOVEN, M. KOOPMAN, and A.M. MAY . Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis. Med. Sci. Sports Exerc., Vol. 56, No. 4, pp. 623- 634, 2024. Introduction: Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until 5 yr postdiagnosis. Methods: Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined. Moderate-to-vigorous PA during sport and leisure time (MVPA-SL) was measured at diagnosis (T0) and 6, 12, 24, and 60 months (T6 to T60) postdiagnosis, using the SQUASH questionnaire. Mixed-effects models were performed to identify sociodemographic and disease-related determinants of MVPA-SL, separately for stage I–III colon (CC), stage I–III rectal cancer (RC), and stage IV CRC (T0 and T6 only). Associations were defined as consistently present when significant at ≥4 timepoints for the stage I–III subsets. MVPA-SL levels were compared with an age- and sex-matched sample of the general Dutch population. Results: In total, 2905 CC, 1459 RC and 436 stage IV CRC patients were included. Patients with higher fatigue scores, and women compared with men had consistently lower MVPA-SL levels over time, regardless of tumor type and stage. At T6, having a stoma was significantly associated with lower MVPA-SL among stage I-III RC patients. Systemic therapy and radiotherapy were not significantly associated with MVPA-SL changes at T6. Compared with the general population, MVPA-SL levels of CRC patients were lower at all timepoints, most notably at T6. Conclusions: Female sex and higher fatigue scores were consistent determinants of lower MVPA-SL levels among all CRC patients, and MVPA-SL levels were lowest at 6 months postdiagnosis. Our results can inform the design of intervention studies aimed at improving PA, and guide healthcare professionals in optimizing individualized support.",

keywords = "COLORECTAL NEOPLASMS, GUIDELINES, HEALTH BEHAVIOR, SPORT PARTICIPATION, SURVIVORSHIP",

author = "Smit, {Karel C.} and Derksen, {Jeroen W. G.} and Stellato, {Rebecca K.} and {van Lanen}, Anne-Sophie and Evertine Wesselink and Belt, {Eric J. T. H.} and Balen, {Marissa Cloos-Van} and Coene, {Peter Paul L. O.} and Dekker, {Jan Willem T.} and {de Groot}, {Jan Willem} and Haringhuizen, {Annebeth W.} and {van Halteren}, {Henk K.} and {van Heek}, {Tjarda T.} and Helgason, {Helgi H.} and Hendriks, {Mathijs P.} and {de Hingh}, {Ignace H. J. T.} and Ronald Hoekstra and Danny Houtsma and Janssen, {Johan J. B.} and Niels, {K. O. K.} and Konsten, {Joop L. M.} and Maartje Los and Meijerink, {Martijn R.} and Mekenkamp, {Leonie J. M.} and Peeters, {Koen C. M. J.} and Pol{\'e}e, {Marco B.} and Rietbroek, {Ron C.} and Schiphorst, {Anandi H. W.} and Schrauwen, {Ruud W. M.} and Jennifer Schreinemakers and Sie, {Mark P. S.} and Lieke Simkens and Sonneveld, {Eric J. A.} and Frederiek Terheggen and Iersel, {Liselot Valkenburg-Van} and Vles, {Wouter J.} and Wasowicz-Kemps, {Daria K.} and {de Wilt}, {Johannes H. W.} and Kok, {Dieuwertje E.} and Winkels, {Renate M.} and Ellen Kampman and {van Duijnhoven}, {Fr{\"a}nzel J. B.} and Miriam Koopman and May, {Anne M.}",

year = "2024",

month = apr,

day = "1",

doi = "10.1249/MSS.0000000000003351",

language = "English",

volume = "56",

pages = "623--634",

journal = "Medicine and science in sports and exercise",

issn = "0195-9131",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

Smit, KC, Derksen, JWG, Stellato, RK, van Lanen, A-S, Wesselink, E, Belt, EJTH, Balen, MC-V, Coene, PPLO, Dekker, JWT, de Groot, JW, Haringhuizen, AW, van Halteren, HK, van Heek, TT, Helgason, HH, Hendriks, MP, de Hingh, IHJT, Hoekstra, R, Houtsma, D, Janssen, JJB, Niels, KOK, Konsten, JLM, Los, M, Meijerink, MR, Mekenkamp, LJM, Peeters, KCMJ, Polée, MB, Rietbroek, RC, Schiphorst, AHW, Schrauwen, RWM, Schreinemakers, J, Sie, MPS, Simkens, L, Sonneveld, EJA, Terheggen, F, Iersel, LV-V, Vles, WJ, Wasowicz-Kemps, DK, de Wilt, JHW, Kok, DE, Winkels, RM, Kampman, E, van Duijnhoven, FJB, Koopman, M & May, AM 2024, 'Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis', Medicine and science in sports and exercise, vol. 56, no. 4, pp. 623-634. https://doi.org/10.1249/MSS.0000000000003351

TY - JOUR

T1 - Determinants of Physical Activity among Patients with Colorectal Cancer

T2 - From Diagnosis to 5 Years after Diagnosis

AU - Smit, Karel C.

AU - Derksen, Jeroen W. G.

AU - Stellato, Rebecca K.

AU - van Lanen, Anne-Sophie

AU - Wesselink, Evertine

AU - Belt, Eric J. T. H.

AU - Balen, Marissa Cloos-Van

AU - Coene, Peter Paul L. O.

AU - Dekker, Jan Willem T.

AU - de Groot, Jan Willem

AU - Haringhuizen, Annebeth W.

AU - van Halteren, Henk K.

AU - van Heek, Tjarda T.

AU - Helgason, Helgi H.

AU - Hendriks, Mathijs P.

AU - de Hingh, Ignace H. J. T.

AU - Hoekstra, Ronald

AU - Houtsma, Danny

AU - Janssen, Johan J. B.

AU - Niels, K. O. K.

AU - Konsten, Joop L. M.

AU - Los, Maartje

AU - Meijerink, Martijn R.

AU - Mekenkamp, Leonie J. M.

AU - Peeters, Koen C. M. J.

AU - Polée, Marco B.

AU - Rietbroek, Ron C.

AU - Schiphorst, Anandi H. W.

AU - Schrauwen, Ruud W. M.

AU - Schreinemakers, Jennifer

AU - Sie, Mark P. S.

AU - Simkens, Lieke

AU - Sonneveld, Eric J. A.

AU - Terheggen, Frederiek

AU - Iersel, Liselot Valkenburg-Van

AU - Vles, Wouter J.

AU - Wasowicz-Kemps, Daria K.

AU - de Wilt, Johannes H. W.

AU - Kok, Dieuwertje E.

AU - Winkels, Renate M.

AU - Kampman, Ellen

AU - van Duijnhoven, Fränzel J. B.

AU - Koopman, Miriam

AU - May, Anne M.

PY - 2024/4/1

Y1 - 2024/4/1

N2 - SMIT K. C., J.W.G. DERKSEN, R. K. STELLATO, A.-S. VAN LANEN, E. WESSELINK, E. J. T. BELT,M. C.-V. BALEN, P. P. L. O. COENE, J. W. T. DEKKER, J. W. DE GROOT, A. W. HARINGHUIZEN, H. K. VAN HALTEREN, T. T. VAN HEEK, H. H. HELGASON, M. P. HENDRIKS, I. H. J. T. DE HINGH, R. HOEKSTRA, D. HOUTSMA, J. J. B. JANSSEN, N. KOK, J. L. M. KONSTEN, M. LOS, M. R. MEIJERINK, L. J. M. MEKENKAMP, K. C. M. J. PEETERS, M. B. POLÉE, R. C. RIETBROEK, A. H. W. SCHIPHORST, R. W. M. SCHRAUWEN, J. SCHREINEMAKERS, M. P. S. SIE, L. SIMKENS, E. J. A. SONNEVELD, F. TERHEGGEN, L. V.-V. IERSEL,W. J. VLES, D. K.WASOWICZ-KEMPS, J. H. W. DEWILT, D. E. KOK, R. M.WINKELS, E. KAMPMAN, F. J. B. VAN DUIJNHOVEN, M. KOOPMAN, and A.M. MAY . Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis. Med. Sci. Sports Exerc., Vol. 56, No. 4, pp. 623- 634, 2024. Introduction: Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until 5 yr postdiagnosis. Methods: Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined. Moderate-to-vigorous PA during sport and leisure time (MVPA-SL) was measured at diagnosis (T0) and 6, 12, 24, and 60 months (T6 to T60) postdiagnosis, using the SQUASH questionnaire. Mixed-effects models were performed to identify sociodemographic and disease-related determinants of MVPA-SL, separately for stage I–III colon (CC), stage I–III rectal cancer (RC), and stage IV CRC (T0 and T6 only). Associations were defined as consistently present when significant at ≥4 timepoints for the stage I–III subsets. MVPA-SL levels were compared with an age- and sex-matched sample of the general Dutch population. Results: In total, 2905 CC, 1459 RC and 436 stage IV CRC patients were included. Patients with higher fatigue scores, and women compared with men had consistently lower MVPA-SL levels over time, regardless of tumor type and stage. At T6, having a stoma was significantly associated with lower MVPA-SL among stage I-III RC patients. Systemic therapy and radiotherapy were not significantly associated with MVPA-SL changes at T6. Compared with the general population, MVPA-SL levels of CRC patients were lower at all timepoints, most notably at T6. Conclusions: Female sex and higher fatigue scores were consistent determinants of lower MVPA-SL levels among all CRC patients, and MVPA-SL levels were lowest at 6 months postdiagnosis. Our results can inform the design of intervention studies aimed at improving PA, and guide healthcare professionals in optimizing individualized support.

AB - SMIT K. C., J.W.G. DERKSEN, R. K. STELLATO, A.-S. VAN LANEN, E. WESSELINK, E. J. T. BELT,M. C.-V. BALEN, P. P. L. O. COENE, J. W. T. DEKKER, J. W. DE GROOT, A. W. HARINGHUIZEN, H. K. VAN HALTEREN, T. T. VAN HEEK, H. H. HELGASON, M. P. HENDRIKS, I. H. J. T. DE HINGH, R. HOEKSTRA, D. HOUTSMA, J. J. B. JANSSEN, N. KOK, J. L. M. KONSTEN, M. LOS, M. R. MEIJERINK, L. J. M. MEKENKAMP, K. C. M. J. PEETERS, M. B. POLÉE, R. C. RIETBROEK, A. H. W. SCHIPHORST, R. W. M. SCHRAUWEN, J. SCHREINEMAKERS, M. P. S. SIE, L. SIMKENS, E. J. A. SONNEVELD, F. TERHEGGEN, L. V.-V. IERSEL,W. J. VLES, D. K.WASOWICZ-KEMPS, J. H. W. DEWILT, D. E. KOK, R. M.WINKELS, E. KAMPMAN, F. J. B. VAN DUIJNHOVEN, M. KOOPMAN, and A.M. MAY . Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis. Med. Sci. Sports Exerc., Vol. 56, No. 4, pp. 623- 634, 2024. Introduction: Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until 5 yr postdiagnosis. Methods: Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined. Moderate-to-vigorous PA during sport and leisure time (MVPA-SL) was measured at diagnosis (T0) and 6, 12, 24, and 60 months (T6 to T60) postdiagnosis, using the SQUASH questionnaire. Mixed-effects models were performed to identify sociodemographic and disease-related determinants of MVPA-SL, separately for stage I–III colon (CC), stage I–III rectal cancer (RC), and stage IV CRC (T0 and T6 only). Associations were defined as consistently present when significant at ≥4 timepoints for the stage I–III subsets. MVPA-SL levels were compared with an age- and sex-matched sample of the general Dutch population. Results: In total, 2905 CC, 1459 RC and 436 stage IV CRC patients were included. Patients with higher fatigue scores, and women compared with men had consistently lower MVPA-SL levels over time, regardless of tumor type and stage. At T6, having a stoma was significantly associated with lower MVPA-SL among stage I-III RC patients. Systemic therapy and radiotherapy were not significantly associated with MVPA-SL changes at T6. Compared with the general population, MVPA-SL levels of CRC patients were lower at all timepoints, most notably at T6. Conclusions: Female sex and higher fatigue scores were consistent determinants of lower MVPA-SL levels among all CRC patients, and MVPA-SL levels were lowest at 6 months postdiagnosis. Our results can inform the design of intervention studies aimed at improving PA, and guide healthcare professionals in optimizing individualized support.

KW - COLORECTAL NEOPLASMS

KW - GUIDELINES

KW - HEALTH BEHAVIOR

KW - SPORT PARTICIPATION

KW - SURVIVORSHIP

UR - http://www.scopus.com/inward/record.url?scp=85187958266&partnerID=8YFLogxK

U2 - 10.1249/MSS.0000000000003351

DO - 10.1249/MSS.0000000000003351

M3 - Article

C2 - 38079324

SN - 0195-9131

VL - 56

SP - 623

EP - 634

JO - Medicine and science in sports and exercise

JF - Medicine and science in sports and exercise

IS - 4

ER -

Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis

Abstract

Keywords

Access to Document

Other files and links

Cite this