Development of a Standardized Set of Patient-centered Outcomes for Advanced Prostate Cancer: An International Effort for a Unified Approach

Alicia K. Morgans; Annelotte C. M. van Bommel; Caleb Stowell; Janet L. Abrahm; Ethan Basch; Justin E. Bekelman; Donna L. Berry; Alberto Bossi; Ian D. Davis; Theo M. de Reijke; Louis J. Denis; Sue M. Evans; Neil E. Fleshner; Daniel J. George; Jim Kiefert; Daniel W. Lin; Andrew G. Matthew; Ray McDermott; Heather Payne; Ian A. G. Roos; Deborah Schrag; Thomas Steuber; Bertrand Tombal; Jean-Paul van Basten; Jacobus J. M. van der Hoeven; David F. Penson

doi:https://doi.org/10.1016/j.eururo.2015.06.007

Development of a Standardized Set of Patient-centered Outcomes for Advanced Prostate Cancer: An International Effort for a Unified Approach

Alicia K. Morgans, Annelotte C. M. van Bommel, Caleb Stowell, Janet L. Abrahm, Ethan Basch, Justin E. Bekelman, Donna L. Berry, Alberto Bossi, Ian D. Davis, Theo M. de Reijke, Louis J. Denis, Sue M. Evans, Neil E. Fleshner, Daniel J. George, Jim Kiefert, Daniel W. Lin, Andrew G. Matthew, Ray McDermott, Heather Payne, Ian A. G. RoosDeborah Schrag, Thomas Steuber, Bertrand Tombal, Jean-Paul van Basten, Jacobus J. M. van der Hoeven, David F. Penson

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

There are no universally monitored outcomes relevant to men with advanced prostate cancer, making it challenging to compare health outcomes between populations. We sought to develop a standard set of outcomes relevant to men with advanced prostate cancer to follow during routine clinical care. The International Consortium for Health Outcomes Measurement assembled a multidisciplinary working group to develop the set. We used a modified Delphi method to achieve consensus regarding the outcomes, measures, and case mix factors included. The 25 members of the multidisciplinary international working group represented academic and nonacademic centers, registries, and patients. Recognizing the heterogeneity of men with advanced prostate cancer, the group defined the scope as men with all stages of incurable prostate cancer (metastatic and biochemical recurrence ineligible for further curative therapy). We defined outcomes important to all men, such as overall survival, and measures specific to subgroups, such as time to metastasis. Measures gathered from clinical data include measures of disease control. We also identified patient-reported outcome measures (PROMs), such as degree of urinary, bowel, and erectile dysfunction, mood symptoms, and pain control. The international multidisciplinary group identified clinical data and PROMs that serve as a basis for international health outcome comparisons and quality-of-care assessments. The set will be revised annually. Our international group has recommended a standardized set of patient-centered outcomes to be followed during routine care for all men with advanced prostate cancer

Original language	English
Pages (from-to)	891-898
Journal	European Urology
Volume	68
Issue number	5
DOIs	https://doi.org/10.1016/j.eururo.2015.06.007
Publication status	Published - 2015

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https://doi.org/10.1016/j.eururo.2015.06.007

Cite this

Morgans, A. K., van Bommel, A. C. M., Stowell, C., Abrahm, J. L., Basch, E., Bekelman, J. E., Berry, D. L., Bossi, A., Davis, I. D., de Reijke, T. M., Denis, L. J., Evans, S. M., Fleshner, N. E., George, D. J., Kiefert, J., Lin, D. W., Matthew, A. G., McDermott, R., Payne, H., ... Penson, D. F. (2015). Development of a Standardized Set of Patient-centered Outcomes for Advanced Prostate Cancer: An International Effort for a Unified Approach. European Urology, 68(5), 891-898. https://doi.org/10.1016/j.eururo.2015.06.007

@article{1ee44814b7844740aae9c235df916164,

title = "Development of a Standardized Set of Patient-centered Outcomes for Advanced Prostate Cancer: An International Effort for a Unified Approach",

abstract = "There are no universally monitored outcomes relevant to men with advanced prostate cancer, making it challenging to compare health outcomes between populations. We sought to develop a standard set of outcomes relevant to men with advanced prostate cancer to follow during routine clinical care. The International Consortium for Health Outcomes Measurement assembled a multidisciplinary working group to develop the set. We used a modified Delphi method to achieve consensus regarding the outcomes, measures, and case mix factors included. The 25 members of the multidisciplinary international working group represented academic and nonacademic centers, registries, and patients. Recognizing the heterogeneity of men with advanced prostate cancer, the group defined the scope as men with all stages of incurable prostate cancer (metastatic and biochemical recurrence ineligible for further curative therapy). We defined outcomes important to all men, such as overall survival, and measures specific to subgroups, such as time to metastasis. Measures gathered from clinical data include measures of disease control. We also identified patient-reported outcome measures (PROMs), such as degree of urinary, bowel, and erectile dysfunction, mood symptoms, and pain control. The international multidisciplinary group identified clinical data and PROMs that serve as a basis for international health outcome comparisons and quality-of-care assessments. The set will be revised annually. Our international group has recommended a standardized set of patient-centered outcomes to be followed during routine care for all men with advanced prostate cancer",

author = "Morgans, {Alicia K.} and {van Bommel}, {Annelotte C. M.} and Caleb Stowell and Abrahm, {Janet L.} and Ethan Basch and Bekelman, {Justin E.} and Berry, {Donna L.} and Alberto Bossi and Davis, {Ian D.} and {de Reijke}, {Theo M.} and Denis, {Louis J.} and Evans, {Sue M.} and Fleshner, {Neil E.} and George, {Daniel J.} and Jim Kiefert and Lin, {Daniel W.} and Matthew, {Andrew G.} and Ray McDermott and Heather Payne and Roos, {Ian A. G.} and Deborah Schrag and Thomas Steuber and Bertrand Tombal and {van Basten}, Jean-Paul and {van der Hoeven}, {Jacobus J. M.} and Penson, {David F.}",

year = "2015",

doi = "https://doi.org/10.1016/j.eururo.2015.06.007",

language = "English",

volume = "68",

pages = "891--898",

journal = "European Urology",

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Morgans, AK, van Bommel, ACM, Stowell, C, Abrahm, JL, Basch, E, Bekelman, JE, Berry, DL, Bossi, A, Davis, ID, de Reijke, TM, Denis, LJ, Evans, SM, Fleshner, NE, George, DJ, Kiefert, J, Lin, DW, Matthew, AG, McDermott, R, Payne, H, Roos, IAG, Schrag, D, Steuber, T, Tombal, B, van Basten, J-P, van der Hoeven, JJM & Penson, DF 2015, 'Development of a Standardized Set of Patient-centered Outcomes for Advanced Prostate Cancer: An International Effort for a Unified Approach', European Urology, vol. 68, no. 5, pp. 891-898. https://doi.org/10.1016/j.eururo.2015.06.007

TY - JOUR

T1 - Development of a Standardized Set of Patient-centered Outcomes for Advanced Prostate Cancer: An International Effort for a Unified Approach

AU - Morgans, Alicia K.

AU - van Bommel, Annelotte C. M.

AU - Stowell, Caleb

AU - Abrahm, Janet L.

AU - Basch, Ethan

AU - Bekelman, Justin E.

AU - Berry, Donna L.

AU - Bossi, Alberto

AU - Davis, Ian D.

AU - de Reijke, Theo M.

AU - Denis, Louis J.

AU - Evans, Sue M.

AU - Fleshner, Neil E.

AU - George, Daniel J.

AU - Kiefert, Jim

AU - Lin, Daniel W.

AU - Matthew, Andrew G.

AU - McDermott, Ray

AU - Payne, Heather

AU - Roos, Ian A. G.

AU - Schrag, Deborah

AU - Steuber, Thomas

AU - Tombal, Bertrand

AU - van Basten, Jean-Paul

AU - van der Hoeven, Jacobus J. M.

AU - Penson, David F.

PY - 2015

Y1 - 2015

N2 - There are no universally monitored outcomes relevant to men with advanced prostate cancer, making it challenging to compare health outcomes between populations. We sought to develop a standard set of outcomes relevant to men with advanced prostate cancer to follow during routine clinical care. The International Consortium for Health Outcomes Measurement assembled a multidisciplinary working group to develop the set. We used a modified Delphi method to achieve consensus regarding the outcomes, measures, and case mix factors included. The 25 members of the multidisciplinary international working group represented academic and nonacademic centers, registries, and patients. Recognizing the heterogeneity of men with advanced prostate cancer, the group defined the scope as men with all stages of incurable prostate cancer (metastatic and biochemical recurrence ineligible for further curative therapy). We defined outcomes important to all men, such as overall survival, and measures specific to subgroups, such as time to metastasis. Measures gathered from clinical data include measures of disease control. We also identified patient-reported outcome measures (PROMs), such as degree of urinary, bowel, and erectile dysfunction, mood symptoms, and pain control. The international multidisciplinary group identified clinical data and PROMs that serve as a basis for international health outcome comparisons and quality-of-care assessments. The set will be revised annually. Our international group has recommended a standardized set of patient-centered outcomes to be followed during routine care for all men with advanced prostate cancer

AB - There are no universally monitored outcomes relevant to men with advanced prostate cancer, making it challenging to compare health outcomes between populations. We sought to develop a standard set of outcomes relevant to men with advanced prostate cancer to follow during routine clinical care. The International Consortium for Health Outcomes Measurement assembled a multidisciplinary working group to develop the set. We used a modified Delphi method to achieve consensus regarding the outcomes, measures, and case mix factors included. The 25 members of the multidisciplinary international working group represented academic and nonacademic centers, registries, and patients. Recognizing the heterogeneity of men with advanced prostate cancer, the group defined the scope as men with all stages of incurable prostate cancer (metastatic and biochemical recurrence ineligible for further curative therapy). We defined outcomes important to all men, such as overall survival, and measures specific to subgroups, such as time to metastasis. Measures gathered from clinical data include measures of disease control. We also identified patient-reported outcome measures (PROMs), such as degree of urinary, bowel, and erectile dysfunction, mood symptoms, and pain control. The international multidisciplinary group identified clinical data and PROMs that serve as a basis for international health outcome comparisons and quality-of-care assessments. The set will be revised annually. Our international group has recommended a standardized set of patient-centered outcomes to be followed during routine care for all men with advanced prostate cancer

U2 - https://doi.org/10.1016/j.eururo.2015.06.007

DO - https://doi.org/10.1016/j.eururo.2015.06.007

M3 - Article

C2 - 26129856

SN - 0302-2838

VL - 68

SP - 891

EP - 898

JO - European Urology

JF - European Urology

IS - 5

ER -