TY - JOUR
T1 - Development of the building plan of the heart
AU - Moorman, Antoon F. M.
AU - Soufan, Alexandre T.
AU - Hagoort, Jaco
AU - de Boer, Piet A. J.
AU - Christoffels, Vincent M.
PY - 2004
Y1 - 2004
N2 - In this communication we discuss the formation of the synchronously contracting chambered heart from a peristaltically contracting linear heart tube. It is proposed that members of the T-box family of transcription factors play a crucial role in the formation of the building plan of the formed heart. Tbx5 may confer venoarterial polarity to the heart tube, whereas Tbx2 initially and Tbx3 in later developmental stages prevent the cardiac inflow tract, atrioventricular region, outflow tract, as well as the cardiac inner curvatures from chamber differentiation. With the exception of the outflow tract that becomes incorporated into the ventricles, these regions contribute to the cardiac conduction system
AB - In this communication we discuss the formation of the synchronously contracting chambered heart from a peristaltically contracting linear heart tube. It is proposed that members of the T-box family of transcription factors play a crucial role in the formation of the building plan of the formed heart. Tbx5 may confer venoarterial polarity to the heart tube, whereas Tbx2 initially and Tbx3 in later developmental stages prevent the cardiac inflow tract, atrioventricular region, outflow tract, as well as the cardiac inner curvatures from chamber differentiation. With the exception of the outflow tract that becomes incorporated into the ventricles, these regions contribute to the cardiac conduction system
U2 - https://doi.org/10.1196/annals.1302.014
DO - https://doi.org/10.1196/annals.1302.014
M3 - Article
C2 - 15201158
SN - 0077-8923
VL - 1015
SP - 171
EP - 181
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -