TY - JOUR
T1 - Developmental course of subclinical positive and negative psychotic symptoms and their associations with genetic risk status and impairment
AU - Janssens, Mayke
AU - Boyette, Lindy-Lou
AU - Heering, Henriëtte D.
AU - Bartels-Velthuis, Agna A.
AU - Lataster, Tineke
AU - AUTHOR GROUP
AU - Kahn, René S.
AU - de Haan, Lieuwe
AU - van Os, Jim
AU - Wiersma, Durk
AU - Bruggeman, Richard
AU - Cahn, Wiepke
AU - Meijer, Carin
AU - Myin-Germeys, Inez
AU - Genetic Risk and Outcome of Psychosis investigators:
N1 - Copyright © 2016. Published by Elsevier B.V.
PY - 2016/7
Y1 - 2016/7
N2 - The proneness-persistence-impairment (PPI) model states that psychotic experiences are more likely to lead to impairment if their expression becomes persistent. Higher genetic risk for psychosis is known to affect proneness and persistence of subclinical positive symptoms. Less is known about potential effects of genetic risk on the course of subclinical negative symptoms, impairment, and their subsequent associations. The current study examined these issues in a large sample (n=1131), consisting of individuals with higher genetic risk (siblings of patients with psychotic disorders, n=703) and lower genetic risk (controls without a family member with lifetime psychosis, n=428). Psychotic experiences were assessed with the CAPE questionnaire, at two time points three years apart. Participants were allocated to one of four groups representing developmental course: stable low, decreasing, increasing or persisting subclinical positive/negative symptoms. Lifetime clinical psychosis was an exclusion criterion at baseline. Higher genetic risk status was found to be associated with a persisting course of both subclinical positive and negative symptoms, symptom-related distress and functional impairment. There is no evidence for an effect of genetic risk status on the association between developmental course and impairment. The results of the current study underline the importance of assessing psychotic experiences in the context of genetic risk, multidimensional and over time. Additionally, the current findings both underscore and contribute to the PPI model: psychotic experiences are more likely to lead to impairment if their expression becomes persistent, both in individuals with higher and lower genetic risk for psychosis
AB - The proneness-persistence-impairment (PPI) model states that psychotic experiences are more likely to lead to impairment if their expression becomes persistent. Higher genetic risk for psychosis is known to affect proneness and persistence of subclinical positive symptoms. Less is known about potential effects of genetic risk on the course of subclinical negative symptoms, impairment, and their subsequent associations. The current study examined these issues in a large sample (n=1131), consisting of individuals with higher genetic risk (siblings of patients with psychotic disorders, n=703) and lower genetic risk (controls without a family member with lifetime psychosis, n=428). Psychotic experiences were assessed with the CAPE questionnaire, at two time points three years apart. Participants were allocated to one of four groups representing developmental course: stable low, decreasing, increasing or persisting subclinical positive/negative symptoms. Lifetime clinical psychosis was an exclusion criterion at baseline. Higher genetic risk status was found to be associated with a persisting course of both subclinical positive and negative symptoms, symptom-related distress and functional impairment. There is no evidence for an effect of genetic risk status on the association between developmental course and impairment. The results of the current study underline the importance of assessing psychotic experiences in the context of genetic risk, multidimensional and over time. Additionally, the current findings both underscore and contribute to the PPI model: psychotic experiences are more likely to lead to impairment if their expression becomes persistent, both in individuals with higher and lower genetic risk for psychosis
KW - Adult
KW - Disease Progression
KW - Female
KW - Follow-Up Studies
KW - Genetic Predisposition to Disease
KW - Humans
KW - Longitudinal Studies
KW - Male
KW - Models, Genetic
KW - Models, Psychological
KW - Phenotype
KW - Psychiatric Status Rating Scales
KW - Psychotic Disorders/genetics
KW - Siblings/psychology
KW - Social Behavior
KW - Surveys and Questionnaires
U2 - https://doi.org/10.1016/j.schres.2016.03.028
DO - https://doi.org/10.1016/j.schres.2016.03.028
M3 - Article
C2 - 27157801
SN - 0920-9964
VL - 174
SP - 177
EP - 182
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -