TY - JOUR
T1 - Diabetes, Atherosclerosis, and Stenosis by AI
AU - Jonas, Rebecca A.
AU - Crabtree, Tami R.
AU - Jennings, Robert S.
AU - Marques, Hugo
AU - Katz, Richard J.
AU - Chang, Hyuk-Jae
AU - Stuijfzand, Wijnand J.
AU - van Rosendael, Alexander R.
AU - Choi, Jung Hyun
AU - Doh, Joon-Hyung
AU - Her, Ae-Young
AU - Koo, Bon-Kwon
AU - Nam, Chang-Wook
AU - Park, Hyung-Bok
AU - Shin, Sang-Hoon
AU - Cole, Jason
AU - Gimelli, Alessia
AU - Khan, Muhammad Akram
AU - Lu, Bin
AU - Gao, Yang
AU - Nabi, Faisal
AU - Nakazato, Ryo
AU - Schoepf, U. Joseph
AU - Driessen, Roel S.
AU - Bom, Michiel J.
AU - Thompson, Randall C.
AU - Jang, James J.
AU - Ridner, Michael
AU - Rowan, Chris
AU - Avelar, Erick
AU - G?n?reux, Philippe
AU - Knaapen, Paul
AU - de Waard, Guus A.
AU - Pontone, Gianluca
AU - Andreini, Daniele
AU - Al-Mallah, Mouaz H.
AU - Guglielmo, Marco
AU - Bax, Jeroen J.
AU - Earls, James P.
AU - Min, James K.
AU - Choi, Andrew D.
AU - Villines, Todd C.
N1 - Funding Information: Funding. A.D.C. is supported by a grant from theGW Heart and Vascular Institute. Duality of Interest. J.P.E., H.M., J.K.M., and A.D.C. have equity interest in Cleerly Inc. J.P.E., R.S.J., T.R.C., and J.K.M. are employees of Cleerly Inc. No other potential conflicts of interest relevant to this article were reported. Author Contributions. R.A.J., J.P.E., R.S.J., T.R.C., J.K.M., A.D.C., and T.C.V. contributed to data analysis and interpretation of results. R.A.J., J.P.E., R.S.J., T.R.C., J.K.M., A.D.C., and T.C.V. contributed to draft manuscript preparation. J.P.E., J.K.M., and A.D.C. contributed to study conception and design. H.M., H.-J.C., J.H.C., J.-H.D, A.-Y.H., B.-K.K., C.-W.N., H.-B.P., S.-H.S., J.C., A.G., M.A.K., B.L., Y.G., F.N., R.N., U.J.S., R.S.D., M.J.B., R.C.T., J.J.J., M.R., C.R., E.A., P.G., P.K., G.A.d.W., G.P., and D.A., Publisher Copyright: © 2023 by the American Diabetes Association.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - OBJECTIVE: This study evaluates the relationship between atherosclerotic plaque characteristics (APCs) and angiographic stenosis severity in patients with and without diabetes. Whether APCs differ based on lesion severity and diabetes status is unknown. RESEARCH DESIGN AND METHODS: We retrospectively evaluated 303 subjects from the Computed TomogRaphic Evaluation of Atherosclerotic Determinants of Myocardial IsChEmia (CREDENCE) trial referred for invasive coronary angiography with coronary computed tomographic angiography (CCTA) and classified lesions as obstructive (?50% stenosed) or nonobstructive using blinded core laboratory analysis of quantitative coronary angiography. CCTA quantified APCs, including plaque volume (PV), calcified plaque (CP), noncalcified plaque (NCP), low-density NCP (LD-NCP), lesion length, positive remodeling (PR), high-risk plaque (HRP), and percentage of atheroma volume (PAV; PV normalized for vessel volume). The relationship between APCs, stenosis severity, and diabetes status was assessed. RESULTS: Among the 303 patients, 95 (31.4%) had diabetes. There were 117 lesions in the cohort with diabetes, 58.1% of which were obstructive. Patients with diabetes had greater plaque burden (P = 0.004). Patients with diabetes and nonobstructive disease had greater PV (P = 0.02), PAV (P = 0.02), NCP (P = 0.03), PAV NCP (P = 0.02), diseased vessels (P = 0.03), and maximum stenosis (P = 0.02) than patients without diabetes with nonobstructive disease. APCs were similar between patients with diabetes with nonobstructive disease and patients without diabetes with obstructive disease. Diabetes status did not affect HRP or PR. Patients with diabetes had similar APCs in obstructive and nonobstructive lesions. CONCLUSIONS: Patients with diabetes and nonobstructive stenosis had an association to similar APCs as patients without diabetes who had obstructive stenosis. Among patients with nonobstructive disease, patients with diabetes had more total PV and NCP.
AB - OBJECTIVE: This study evaluates the relationship between atherosclerotic plaque characteristics (APCs) and angiographic stenosis severity in patients with and without diabetes. Whether APCs differ based on lesion severity and diabetes status is unknown. RESEARCH DESIGN AND METHODS: We retrospectively evaluated 303 subjects from the Computed TomogRaphic Evaluation of Atherosclerotic Determinants of Myocardial IsChEmia (CREDENCE) trial referred for invasive coronary angiography with coronary computed tomographic angiography (CCTA) and classified lesions as obstructive (?50% stenosed) or nonobstructive using blinded core laboratory analysis of quantitative coronary angiography. CCTA quantified APCs, including plaque volume (PV), calcified plaque (CP), noncalcified plaque (NCP), low-density NCP (LD-NCP), lesion length, positive remodeling (PR), high-risk plaque (HRP), and percentage of atheroma volume (PAV; PV normalized for vessel volume). The relationship between APCs, stenosis severity, and diabetes status was assessed. RESULTS: Among the 303 patients, 95 (31.4%) had diabetes. There were 117 lesions in the cohort with diabetes, 58.1% of which were obstructive. Patients with diabetes had greater plaque burden (P = 0.004). Patients with diabetes and nonobstructive disease had greater PV (P = 0.02), PAV (P = 0.02), NCP (P = 0.03), PAV NCP (P = 0.02), diseased vessels (P = 0.03), and maximum stenosis (P = 0.02) than patients without diabetes with nonobstructive disease. APCs were similar between patients with diabetes with nonobstructive disease and patients without diabetes with obstructive disease. Diabetes status did not affect HRP or PR. Patients with diabetes had similar APCs in obstructive and nonobstructive lesions. CONCLUSIONS: Patients with diabetes and nonobstructive stenosis had an association to similar APCs as patients without diabetes who had obstructive stenosis. Among patients with nonobstructive disease, patients with diabetes had more total PV and NCP.
UR - http://www.scopus.com/inward/record.url?scp=85147047517&partnerID=8YFLogxK
U2 - https://doi.org/10.2337/dc21-1663
DO - https://doi.org/10.2337/dc21-1663
M3 - Article
C2 - 36577120
SN - 0149-5992
VL - 46
SP - 416
EP - 424
JO - Diabetes Care
JF - Diabetes Care
IS - 2
ER -