Diagnostiek van frontotemporale dementie in de psychiatrische praktijk: handvatten en valkuilen

Translated title of the contribution: Diagnostics of frontotemporal dementia in psychiatric practice: Guides and pitfalls

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BACKGROUND: The behavioural variant of frontotemporal dementia (bvFTD) strongly resembles primary psychiatric disorders. Furthermore, a bvFTD mimic may occur, without neurodegenerative aetiology. AIM: To offer psychiatrist clinical tools for making or ruling out a bvFTD diagnosis. METHOD: To present the results of the first prospective cohort study on bvFTD patients and primary psychiatric patients. Results are discussed within the context of the international literature. RESULTS: Frontotemporal atrophy on imaging confirms a suspected bvFTD diagnosis. Merely fulfilling the bvFTD clinical criteria, with or without frontotemporal hypometabolism on functional imaging, may also result from primary psychiatric disorders or the bvFTD-phenocopy syndrome. A high level of stereotypy, hyperorality, a low level of depressive symptoms, impaired social cognition or absent insight increases the probability of bvFTD. Biomarker or genetic tests and follow-up are recommended. CONCLUSIONS A bvFTD diagnosis should be made multidisciplinary. Without the confirmation of atrophy or genetics, great reserve in making the diagnosis is in place and careful analyses for psychiatric aetiologies is advised.
Translated title of the contributionDiagnostics of frontotemporal dementia in psychiatric practice: Guides and pitfalls
Original languageDutch
Pages (from-to)366-373
Number of pages8
JournalTijdschrift voor Psychiatrie
Issue number5
Publication statusPublished - May 2021

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