Diagnostische en farmacotherapeutische opties bij acuut ernstig bloedverlies

P. W. Kamphuisen; M. [=Marcel M.] Levi; M. G. J. van Kraaij; H. A. H. Kaasjager; J. P. M. Frölke

Diagnostische en farmacotherapeutische opties bij acuut ernstig bloedverlies

P. W. Kamphuisen, M. [=Marcel M.] Levi, M. G. J. van Kraaij, H. A. H. Kaasjager, J. P. M. Frölke

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2 Citations (Scopus)

Abstract

In patients with excessive blood loss, coagulation is compromised by hypothermia, metabolic acidosis due to impaired tissue perfusion, loss of coagulation factors and platelets while their consumption is increased, and by massive infusion with plasma expanders. Currently available laboratory tests are insufficiently reliable and too time-consuming to enable the evaluation of the effect of pharmaco-therapeutic interventions during severe blood loss. Several haemostatic drugs appear to be effective in the treatment of blood loss after elective surgery, but have been insufficiently investigated in patients with severe bleeding. A rational transfusion policy entailing the use of sufficient amounts of plasma is necessary in the treatment of patients with severe bleeding

Original language	Dutch
Pages (from-to)	1907-1911
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	148
Issue number	39
Publication status	Published - 2004

Cite this

@article{2f8374d71bd34d9bb2c00a9067f3fe12,

title = "Diagnostische en farmacotherapeutische opties bij acuut ernstig bloedverlies",

abstract = "In patients with excessive blood loss, coagulation is compromised by hypothermia, metabolic acidosis due to impaired tissue perfusion, loss of coagulation factors and platelets while their consumption is increased, and by massive infusion with plasma expanders. Currently available laboratory tests are insufficiently reliable and too time-consuming to enable the evaluation of the effect of pharmaco-therapeutic interventions during severe blood loss. Several haemostatic drugs appear to be effective in the treatment of blood loss after elective surgery, but have been insufficiently investigated in patients with severe bleeding. A rational transfusion policy entailing the use of sufficient amounts of plasma is necessary in the treatment of patients with severe bleeding",

author = "Kamphuisen, {P. W.} and Levi, {M. [=Marcel M.]} and {van Kraaij}, {M. G. J.} and Kaasjager, {H. A. H.} and Fr{\"o}lke, {J. P. M.}",

year = "2004",

language = "Dutch",

volume = "148",

pages = "1907--1911",

journal = "Nederlands Tijdschrift voor Geneeskunde",

issn = "0028-2162",

publisher = "Vereniging Nederlands Tijdschrift voor Geneeskunde",

number = "39",

}

TY - JOUR

T1 - Diagnostische en farmacotherapeutische opties bij acuut ernstig bloedverlies

AU - Kamphuisen, P. W.

AU - Levi, M. [=Marcel M.]

AU - van Kraaij, M. G. J.

AU - Kaasjager, H. A. H.

AU - Frölke, J. P. M.

PY - 2004

Y1 - 2004

N2 - In patients with excessive blood loss, coagulation is compromised by hypothermia, metabolic acidosis due to impaired tissue perfusion, loss of coagulation factors and platelets while their consumption is increased, and by massive infusion with plasma expanders. Currently available laboratory tests are insufficiently reliable and too time-consuming to enable the evaluation of the effect of pharmaco-therapeutic interventions during severe blood loss. Several haemostatic drugs appear to be effective in the treatment of blood loss after elective surgery, but have been insufficiently investigated in patients with severe bleeding. A rational transfusion policy entailing the use of sufficient amounts of plasma is necessary in the treatment of patients with severe bleeding

AB - In patients with excessive blood loss, coagulation is compromised by hypothermia, metabolic acidosis due to impaired tissue perfusion, loss of coagulation factors and platelets while their consumption is increased, and by massive infusion with plasma expanders. Currently available laboratory tests are insufficiently reliable and too time-consuming to enable the evaluation of the effect of pharmaco-therapeutic interventions during severe blood loss. Several haemostatic drugs appear to be effective in the treatment of blood loss after elective surgery, but have been insufficiently investigated in patients with severe bleeding. A rational transfusion policy entailing the use of sufficient amounts of plasma is necessary in the treatment of patients with severe bleeding

M3 - Article

C2 - 15495987

SN - 0028-2162

VL - 148

SP - 1907

EP - 1911

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

IS - 39

ER -