TY - JOUR
T1 - Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction
AU - Kater, Arnon P.
AU - Peppelenbosch, Maikel P.
AU - Brandjes, Dees P. M.
AU - Lumbantobing, Mika
PY - 2002
Y1 - 2002
N2 - Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation Of I-kappaB but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin
AB - Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation Of I-kappaB but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin
U2 - https://doi.org/10.1128/CDLI.9.6.1396-1397.2002
DO - https://doi.org/10.1128/CDLI.9.6.1396-1397.2002
M3 - Article
C2 - 12414784
SN - 1071-412X
VL - 9
SP - 1396
EP - 1397
JO - Clinical and diagnostic laboratory immunology
JF - Clinical and diagnostic laboratory immunology
IS - 6
ER -