TY - JOUR
T1 - Dietary interventions for functional abdominal pain disorders in children
T2 - a systematic review and meta-analysis
AU - de Bruijn, Clara M. A.
AU - Rexwinkel, Robyn
AU - Gordon, Morris
AU - Sinopoulou, Vassiliki
AU - Benninga, Marc A.
AU - Tabbers, Merit M.
N1 - Funding Information: The authors have no funding to report. We acknowledge the great work and contributions by Yuhong Yuan. She developed the search strategies (Information Specialist, Cochrane Gut Group). We are grateful to the authors who kindly responded to our request for clarification of the protocol and additional data on the trials in which they were involved. Publisher Copyright: © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Background: Functional abdominal pain disorders (FAPDs) are common among children and are associated with decreased quality of life and school attendance. Several dietary interventions have been suggested to improve symptoms of FAPDs. This systematic review assessed the efficacy and safety of dietary interventions for pediatric FAPDs. Design and methods: Electronic databases were searched (inception–October 2021). Systematic reviews or RCTs were included if children (4–18 years) with FAPDs were treated with dietary interventions and compared to placebo, no diet or any other diet. Data extraction and assessment of quality of evidence based on GRADE system was independently performed by two review authors. Outcomes were treatment success, pain intensity and frequency, and withdrawal due to adverse events. Results: Twelve articles were included, representing data of 819 pediatric FAPD patients. Trials investigating fibers, FODMAP diet, fructans, fructose-restricted diet, prebiotic (inulin), serum-derived bovine immunoglobulin, and vitamin D supplementation were included. We found very low-certainty evidence that the use of fibers leads to higher treatment success (NNT = 5). Conclusion: Based on current evidence, the use of fibers can be discussed in daily practice. High-quality intervention trials are highly needed to investigate if other dietary interventions are effective in the treatment of pediatric FAPD.
AB - Background: Functional abdominal pain disorders (FAPDs) are common among children and are associated with decreased quality of life and school attendance. Several dietary interventions have been suggested to improve symptoms of FAPDs. This systematic review assessed the efficacy and safety of dietary interventions for pediatric FAPDs. Design and methods: Electronic databases were searched (inception–October 2021). Systematic reviews or RCTs were included if children (4–18 years) with FAPDs were treated with dietary interventions and compared to placebo, no diet or any other diet. Data extraction and assessment of quality of evidence based on GRADE system was independently performed by two review authors. Outcomes were treatment success, pain intensity and frequency, and withdrawal due to adverse events. Results: Twelve articles were included, representing data of 819 pediatric FAPD patients. Trials investigating fibers, FODMAP diet, fructans, fructose-restricted diet, prebiotic (inulin), serum-derived bovine immunoglobulin, and vitamin D supplementation were included. We found very low-certainty evidence that the use of fibers leads to higher treatment success (NNT = 5). Conclusion: Based on current evidence, the use of fibers can be discussed in daily practice. High-quality intervention trials are highly needed to investigate if other dietary interventions are effective in the treatment of pediatric FAPD.
KW - Abdominal pain
KW - diet
KW - meta-analysis
KW - pediatric
UR - http://www.scopus.com/inward/record.url?scp=85127602778&partnerID=8YFLogxK
U2 - https://doi.org/10.1080/17474124.2022.2055547
DO - https://doi.org/10.1080/17474124.2022.2055547
M3 - Article
C2 - 35311425
SN - 1747-4124
VL - 16
SP - 359
EP - 371
JO - Expert review of gastroenterology and hepatology
JF - Expert review of gastroenterology and hepatology
IS - 4
ER -