TY - JOUR
T1 - Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes
AU - Beulens, Joline W.J.
AU - Van Der A, Daphne L.
AU - Grobbee, Diederick E.
AU - Sluijs, Ivonne
AU - Spijkerman, Annemieke M.W.
AU - Van Der Schouw, Yvonne T.
PY - 2010/8/1
Y1 - 2010/8/1
N2 - OBJECTIVE- To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS- We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validated food frequency questionnaire. Diabetes case patients were ascertained mainly via self-report and verified against medical records. RESULTS- During 10.3 years of follow-up, 918 incident cases of diabetes were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (P = 0.08) with a reduced risk of type 2 diabetes with a hazard ratio (HR) of 0.81 (95% CI 0.66-0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (P = 0.038) with risk of type 2 diabetes was observed with an HR of 0.93 (0.87-1.00) for each 10-μg increment in the multivariate model. CONCLUSIONS- This study shows that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes.
AB - OBJECTIVE- To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS- We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validated food frequency questionnaire. Diabetes case patients were ascertained mainly via self-report and verified against medical records. RESULTS- During 10.3 years of follow-up, 918 incident cases of diabetes were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (P = 0.08) with a reduced risk of type 2 diabetes with a hazard ratio (HR) of 0.81 (95% CI 0.66-0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (P = 0.038) with risk of type 2 diabetes was observed with an HR of 0.93 (0.87-1.00) for each 10-μg increment in the multivariate model. CONCLUSIONS- This study shows that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes.
UR - http://www.scopus.com/inward/record.url?scp=77958198463&partnerID=8YFLogxK
U2 - https://doi.org/10.2337/dc09-2302
DO - https://doi.org/10.2337/dc09-2302
M3 - Article
C2 - 20424220
SN - 0149-5992
VL - 33
SP - 1699
EP - 1705
JO - Diabetes Care
JF - Diabetes Care
IS - 8
ER -