Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: The EPIC-InterAct study

S. Abbas; J. Linseisen; S. Rohrmann; J. W.J. Beulens; B. Buijsse; P. Amiano; E. Ardanaz; B. Balkau; H. Boeing; F. Clavel-Chapelon; G. Fagherazzi; P. W. Franks; D. Gavrila; S. Grioni; R. Kaaks; T. J. Key; K. T. Khaw; T. Kühn; A. Mattiello; E. Molina-Montes; P. M. Nilsson; K. Overvad; J. R. Quirós; O. Rolandsson; C. Sacerdote; C. Saieva; N. Slimani; I. Sluijs; A. M.W. Spijkerman; A. Tjonneland; R. Tumino; D. L. Van Der A; R. Zamora-Ros; S. J. Sharp; C. Langenberg; N. G. Forouhi; E. Riboli; N. J. Wareham

doi:https://doi.org/10.1038/ejcn.2013.235

Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: The EPIC-InterAct study

S. Abbas, J. Linseisen, S. Rohrmann, J. W.J. Beulens, B. Buijsse, P. Amiano, E. Ardanaz, B. Balkau, H. Boeing, F. Clavel-Chapelon, G. Fagherazzi, P. W. Franks, D. Gavrila, S. Grioni, R. Kaaks, T. J. Key, K. T. Khaw, T. Kühn, A. Mattiello, E. Molina-MontesP. M. Nilsson, K. Overvad, J. R. Quirós, O. Rolandsson, C. Sacerdote, C. Saieva, N. Slimani, I. Sluijs, A. M.W. Spijkerman, A. Tjonneland, R. Tumino, D. L. Van Der A, R. Zamora-Ros, S. J. Sharp, C. Langenberg, N. G. Forouhi, E. Riboli, N. J. Wareham

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background/Objectives: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation. Subjects/Methods: Using a case-cohort design, 11 245 incident cases of type 2 diabetes and a representative subcohort (N=15 798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N=2347) were used to calibrate habitual intake data derived from dietary questionnaires. Results: Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (P_trend =0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 μg/day dietary vitamin D. Conclusions: This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.

Original language	English
Pages (from-to)	196-202
Number of pages	7
Journal	European Journal of Clinical Nutrition
Volume	68
Issue number	2
DOIs	https://doi.org/10.1038/ejcn.2013.235
Publication status	Published - 1 Feb 2014

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Abbas, S., Linseisen, J., Rohrmann, S., Beulens, J. W. J., Buijsse, B., Amiano, P., Ardanaz, E., Balkau, B., Boeing, H., Clavel-Chapelon, F., Fagherazzi, G., Franks, P. W., Gavrila, D., Grioni, S., Kaaks, R., Key, T. J., Khaw, K. T., Kühn, T., Mattiello, A., ... Wareham, N. J. (2014). Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: The EPIC-InterAct study. European Journal of Clinical Nutrition, 68(2), 196-202. https://doi.org/10.1038/ejcn.2013.235

@article{31dfefe738d54657a6ecda9743edabfe,

title = "Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: The EPIC-InterAct study",

abstract = "Background/Objectives: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation. Subjects/Methods: Using a case-cohort design, 11 245 incident cases of type 2 diabetes and a representative subcohort (N=15 798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N=2347) were used to calibrate habitual intake data derived from dietary questionnaires. Results: Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (Ptrend =0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 μg/day dietary vitamin D. Conclusions: This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.",

author = "S. Abbas and J. Linseisen and S. Rohrmann and Beulens, {J. W.J.} and B. Buijsse and P. Amiano and E. Ardanaz and B. Balkau and H. Boeing and F. Clavel-Chapelon and G. Fagherazzi and Franks, {P. W.} and D. Gavrila and S. Grioni and R. Kaaks and Key, {T. J.} and Khaw, {K. T.} and T. K{\"u}hn and A. Mattiello and E. Molina-Montes and Nilsson, {P. M.} and K. Overvad and Quir{\'o}s, {J. R.} and O. Rolandsson and C. Sacerdote and C. Saieva and N. Slimani and I. Sluijs and Spijkerman, {A. M.W.} and A. Tjonneland and R. Tumino and {Van Der A}, {D. L.} and R. Zamora-Ros and Sharp, {S. J.} and C. Langenberg and Forouhi, {N. G.} and E. Riboli and Wareham, {N. J.}",

year = "2014",

month = feb,

day = "1",

doi = "https://doi.org/10.1038/ejcn.2013.235",

language = "English",

volume = "68",

pages = "196--202",

journal = "European Journal of Clinical Nutrition",

issn = "0954-3007",

publisher = "Springer Nature",

number = "2",

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Abbas, S, Linseisen, J, Rohrmann, S, Beulens, JWJ, Buijsse, B, Amiano, P, Ardanaz, E, Balkau, B, Boeing, H, Clavel-Chapelon, F, Fagherazzi, G, Franks, PW, Gavrila, D, Grioni, S, Kaaks, R, Key, TJ, Khaw, KT, Kühn, T, Mattiello, A, Molina-Montes, E, Nilsson, PM, Overvad, K, Quirós, JR, Rolandsson, O, Sacerdote, C, Saieva, C, Slimani, N, Sluijs, I, Spijkerman, AMW, Tjonneland, A, Tumino, R, Van Der A, DL, Zamora-Ros, R, Sharp, SJ, Langenberg, C, Forouhi, NG, Riboli, E & Wareham, NJ 2014, 'Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: The EPIC-InterAct study', European Journal of Clinical Nutrition, vol. 68, no. 2, pp. 196-202. https://doi.org/10.1038/ejcn.2013.235

TY - JOUR

T1 - Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition

T2 - The EPIC-InterAct study

AU - Abbas, S.

AU - Linseisen, J.

AU - Rohrmann, S.

AU - Beulens, J. W.J.

AU - Buijsse, B.

AU - Amiano, P.

AU - Ardanaz, E.

AU - Balkau, B.

AU - Boeing, H.

AU - Clavel-Chapelon, F.

AU - Fagherazzi, G.

AU - Franks, P. W.

AU - Gavrila, D.

AU - Grioni, S.

AU - Kaaks, R.

AU - Key, T. J.

AU - Khaw, K. T.

AU - Kühn, T.

AU - Mattiello, A.

AU - Molina-Montes, E.

AU - Nilsson, P. M.

AU - Overvad, K.

AU - Quirós, J. R.

AU - Rolandsson, O.

AU - Sacerdote, C.

AU - Saieva, C.

AU - Slimani, N.

AU - Sluijs, I.

AU - Spijkerman, A. M.W.

AU - Tjonneland, A.

AU - Tumino, R.

AU - Van Der A, D. L.

AU - Zamora-Ros, R.

AU - Sharp, S. J.

AU - Langenberg, C.

AU - Forouhi, N. G.

AU - Riboli, E.

AU - Wareham, N. J.

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Background/Objectives: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation. Subjects/Methods: Using a case-cohort design, 11 245 incident cases of type 2 diabetes and a representative subcohort (N=15 798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N=2347) were used to calibrate habitual intake data derived from dietary questionnaires. Results: Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (Ptrend =0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 μg/day dietary vitamin D. Conclusions: This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.

AB - Background/Objectives: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation. Subjects/Methods: Using a case-cohort design, 11 245 incident cases of type 2 diabetes and a representative subcohort (N=15 798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N=2347) were used to calibrate habitual intake data derived from dietary questionnaires. Results: Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (Ptrend =0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 μg/day dietary vitamin D. Conclusions: This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.

UR - http://www.scopus.com/inward/record.url?scp=84893740785&partnerID=8YFLogxK

U2 - https://doi.org/10.1038/ejcn.2013.235

DO - https://doi.org/10.1038/ejcn.2013.235

M3 - Article

C2 - 24253760

SN - 0954-3007

VL - 68

SP - 196

EP - 202

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

IS - 2

ER -

Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: The EPIC-InterAct study

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