Differences in cardiovascular risk factors and clinical outcomes between Western European and Southeast Asian patients treated with the Genous Bio-engineered R stent: an e-HEALING worldwide registry substudy

AUTHOR GROUP

doi:https://doi.org/10.1097/MCA.0b013e328351aaed

Differences in cardiovascular risk factors and clinical outcomes between Western European and Southeast Asian patients treated with the Genous Bio-engineered R stent: an e-HEALING worldwide registry substudy

AUTHOR GROUP

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

Objective Percutaneous coronary interventions (PCIs) are increasingly being performed worldwide to treat patients with coronary artery disease. However, studies on the influence of ethnicity on clinical outcomes after PCI are scarce. In our current analysis, we evaluate the differences in baseline clinical, angiographic and procedural characteristics, and 12-month clinical outcomes in patients undergoing nonurgent PCI in Western Europe and in Asia. Methods We analyzed all patients enrolled in the worldwide e-HEALING (electronic Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth) registry living in Western Europe and Asia. All patients were treated with at least one endothelial progenitor cell capturing stent. The main study outcome was target vessel failure at the 12-month follow-up, defined as the composite of cardiac death or myocardial infarction and target vessel revascularization. Results A total of 3504 patients, 2873 living in Western Europe and 731 living in Asia, were assessed in the current analysis. Almost all of the baseline clinical and angiographic characteristics differed significantly between both populations. Target vessel failure at the 12-month follow-up occurred in 11.4% of the Western Europe patients and in 5.6% of the Asian patients (P <0.01). Conclusion We conclude that differences exist in the baseline, angiographic, and procedural characteristics between Western European and Asian patients undergoing nonurgent PCI. In addition, the 1-year clinical outcomes differ significantly after PCI between Western European and Asian patients. Our results indicate that reports from studies performed worldwide should include both overall and regional subgroup outcomes. Coron Artery Dis 23: 271-277 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins. Coronary Artery Disease 2012, 23: 271-277

Original language	English
Pages (from-to)	271-277
Journal	Coronary artery disease
Volume	23
Issue number	4
DOIs	https://doi.org/10.1097/MCA.0b013e328351aaed
Publication status	Published - 2012

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https://doi.org/10.1097/MCA.0b013e328351aaed

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@article{ffc772e5981e4f298b4ce7664c4a125f,

title = "Differences in cardiovascular risk factors and clinical outcomes between Western European and Southeast Asian patients treated with the Genous Bio-engineered R stent: an e-HEALING worldwide registry substudy",

abstract = "Objective Percutaneous coronary interventions (PCIs) are increasingly being performed worldwide to treat patients with coronary artery disease. However, studies on the influence of ethnicity on clinical outcomes after PCI are scarce. In our current analysis, we evaluate the differences in baseline clinical, angiographic and procedural characteristics, and 12-month clinical outcomes in patients undergoing nonurgent PCI in Western Europe and in Asia. Methods We analyzed all patients enrolled in the worldwide e-HEALING (electronic Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth) registry living in Western Europe and Asia. All patients were treated with at least one endothelial progenitor cell capturing stent. The main study outcome was target vessel failure at the 12-month follow-up, defined as the composite of cardiac death or myocardial infarction and target vessel revascularization. Results A total of 3504 patients, 2873 living in Western Europe and 731 living in Asia, were assessed in the current analysis. Almost all of the baseline clinical and angiographic characteristics differed significantly between both populations. Target vessel failure at the 12-month follow-up occurred in 11.4% of the Western Europe patients and in 5.6% of the Asian patients (P <0.01). Conclusion We conclude that differences exist in the baseline, angiographic, and procedural characteristics between Western European and Asian patients undergoing nonurgent PCI. In addition, the 1-year clinical outcomes differ significantly after PCI between Western European and Asian patients. Our results indicate that reports from studies performed worldwide should include both overall and regional subgroup outcomes. Coron Artery Dis 23: 271-277 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins. Coronary Artery Disease 2012, 23: 271-277",

author = "Margo Klomp and Peter Damman and Beijk, {Marcel A. M.} and Tan, {Kim H.} and Vruyr Balian and {De Luca}, Giuseppe and Tijssen, {Jan G. P.} and S. Silber and {de Winter}, {Robbert J.} and {AUTHOR GROUP} and H. Brussee and D. Glogar and D. Botegal and J. Altenberger and S. Weber and K. Kaspar and H. Koller and G. Helmreich and E. Benit and N. Debbas and J. Lalmand and S. Helqvist and P. Thayssen and A. Ylitalo and G. Dambrin and G. Grollier and A. Gommeaux and E. Teiger and Morice, {M. C.} and P. Goube and A. Utech and B. Lauer and M. Wiemer and M. Haude and V. Sch{\"a}chinger and E. Fleck and J. Brachmann and W. Bocksch and C. Nienaber and J. Eberhard and D. Foley and V. Balian and {de Luca}, G. and A. Carcagn{\'i} and G. Carosio and M. Galli and {de Benedictis}, M. and Biondo, {G. B.} and A. Fiscella and A. Benassi and G. GeracI",

year = "2012",

doi = "https://doi.org/10.1097/MCA.0b013e328351aaed",

language = "English",

volume = "23",

pages = "271--277",

journal = "Coronary artery disease",

issn = "0954-6928",

publisher = "Lippincott Williams & Wilkins",

number = "4",

}

TY - JOUR

T1 - Differences in cardiovascular risk factors and clinical outcomes between Western European and Southeast Asian patients treated with the Genous Bio-engineered R stent: an e-HEALING worldwide registry substudy

AU - Klomp, Margo

AU - Damman, Peter

AU - Beijk, Marcel A. M.

AU - Tan, Kim H.

AU - Balian, Vruyr

AU - De Luca, Giuseppe

AU - Tijssen, Jan G. P.

AU - Silber, S.

AU - de Winter, Robbert J.

AU - AUTHOR GROUP

AU - Brussee, H.

AU - Glogar, D.

AU - Botegal, D.

AU - Altenberger, J.

AU - Weber, S.

AU - Kaspar, K.

AU - Koller, H.

AU - Helmreich, G.

AU - Benit, E.

AU - Debbas, N.

AU - Lalmand, J.

AU - Helqvist, S.

AU - Thayssen, P.

AU - Ylitalo, A.

AU - Dambrin, G.

AU - Grollier, G.

AU - Gommeaux, A.

AU - Teiger, E.

AU - Morice, M. C.

AU - Goube, P.

AU - Utech, A.

AU - Lauer, B.

AU - Wiemer, M.

AU - Haude, M.

AU - Schächinger, V.

AU - Fleck, E.

AU - Brachmann, J.

AU - Bocksch, W.

AU - Nienaber, C.

AU - Eberhard, J.

AU - Foley, D.

AU - Balian, V.

AU - de Luca, G.

AU - Carcagní, A.

AU - Carosio, G.

AU - Galli, M.

AU - de Benedictis, M.

AU - Biondo, G. B.

AU - Fiscella, A.

AU - Benassi, A.

AU - GeracI, G.

PY - 2012

Y1 - 2012

N2 - Objective Percutaneous coronary interventions (PCIs) are increasingly being performed worldwide to treat patients with coronary artery disease. However, studies on the influence of ethnicity on clinical outcomes after PCI are scarce. In our current analysis, we evaluate the differences in baseline clinical, angiographic and procedural characteristics, and 12-month clinical outcomes in patients undergoing nonurgent PCI in Western Europe and in Asia. Methods We analyzed all patients enrolled in the worldwide e-HEALING (electronic Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth) registry living in Western Europe and Asia. All patients were treated with at least one endothelial progenitor cell capturing stent. The main study outcome was target vessel failure at the 12-month follow-up, defined as the composite of cardiac death or myocardial infarction and target vessel revascularization. Results A total of 3504 patients, 2873 living in Western Europe and 731 living in Asia, were assessed in the current analysis. Almost all of the baseline clinical and angiographic characteristics differed significantly between both populations. Target vessel failure at the 12-month follow-up occurred in 11.4% of the Western Europe patients and in 5.6% of the Asian patients (P <0.01). Conclusion We conclude that differences exist in the baseline, angiographic, and procedural characteristics between Western European and Asian patients undergoing nonurgent PCI. In addition, the 1-year clinical outcomes differ significantly after PCI between Western European and Asian patients. Our results indicate that reports from studies performed worldwide should include both overall and regional subgroup outcomes. Coron Artery Dis 23: 271-277 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins. Coronary Artery Disease 2012, 23: 271-277

AB - Objective Percutaneous coronary interventions (PCIs) are increasingly being performed worldwide to treat patients with coronary artery disease. However, studies on the influence of ethnicity on clinical outcomes after PCI are scarce. In our current analysis, we evaluate the differences in baseline clinical, angiographic and procedural characteristics, and 12-month clinical outcomes in patients undergoing nonurgent PCI in Western Europe and in Asia. Methods We analyzed all patients enrolled in the worldwide e-HEALING (electronic Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth) registry living in Western Europe and Asia. All patients were treated with at least one endothelial progenitor cell capturing stent. The main study outcome was target vessel failure at the 12-month follow-up, defined as the composite of cardiac death or myocardial infarction and target vessel revascularization. Results A total of 3504 patients, 2873 living in Western Europe and 731 living in Asia, were assessed in the current analysis. Almost all of the baseline clinical and angiographic characteristics differed significantly between both populations. Target vessel failure at the 12-month follow-up occurred in 11.4% of the Western Europe patients and in 5.6% of the Asian patients (P <0.01). Conclusion We conclude that differences exist in the baseline, angiographic, and procedural characteristics between Western European and Asian patients undergoing nonurgent PCI. In addition, the 1-year clinical outcomes differ significantly after PCI between Western European and Asian patients. Our results indicate that reports from studies performed worldwide should include both overall and regional subgroup outcomes. Coron Artery Dis 23: 271-277 (C) 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins. Coronary Artery Disease 2012, 23: 271-277

U2 - https://doi.org/10.1097/MCA.0b013e328351aaed

DO - https://doi.org/10.1097/MCA.0b013e328351aaed

M3 - Article

C2 - 22473083

SN - 0954-6928

VL - 23

SP - 271

EP - 277

JO - Coronary artery disease

JF - Coronary artery disease

IS - 4

ER -