TY - JOUR
T1 - Differences in heart rate variability between depressed and non-depressed elderly
AU - van der Kooy, Koen G.
AU - van Hout, Hein P.J.
AU - van Marwijk, Harm W.J.
AU - de Haan, Marten
AU - Stehouwer, Coen D.A.
AU - Beekman, Aartjan T.F.
PY - 2006/2
Y1 - 2006/2
N2 - Objective: To determine whether older primary care patients with a Major Depressive Disorder (MDD) have lower heart rate variability (HRV) compared to non-depressed patients. HRV is a measure of cardiac autonomic functioning. Method: A cross-sectional comparison of 136 elderly persons with MDD and 136 non-depressed controls (matched for age and gender) recruited in family practices in the Netherlands. Depression was determined according to the DSM-IV criteria using the PRIME-MD. HRV was measured with an electrocardiogram (ECG) during a 5-minute supine rest. Results: Multivariate analyses showed statistically significant decrease in HRV in MDD patients compared with controls. Conclusion: Older primary care patients with MDD have a reduced HRV. This may explain why depression is a risk factor for cardiovascular disease and mortality.
AB - Objective: To determine whether older primary care patients with a Major Depressive Disorder (MDD) have lower heart rate variability (HRV) compared to non-depressed patients. HRV is a measure of cardiac autonomic functioning. Method: A cross-sectional comparison of 136 elderly persons with MDD and 136 non-depressed controls (matched for age and gender) recruited in family practices in the Netherlands. Depression was determined according to the DSM-IV criteria using the PRIME-MD. HRV was measured with an electrocardiogram (ECG) during a 5-minute supine rest. Results: Multivariate analyses showed statistically significant decrease in HRV in MDD patients compared with controls. Conclusion: Older primary care patients with MDD have a reduced HRV. This may explain why depression is a risk factor for cardiovascular disease and mortality.
KW - Autonomic nervous system
KW - Heart rate variability
KW - Major depression
KW - Primary care
UR - http://www.scopus.com/inward/record.url?scp=32544453363&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/gps.1439
DO - https://doi.org/10.1002/gps.1439
M3 - Article
C2 - 16416460
SN - 0885-6230
VL - 21
SP - 147
EP - 150
JO - International journal of geriatric psychiatry
JF - International journal of geriatric psychiatry
IS - 2
ER -