Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis

Wirongrong Chierakul; Maaike de Fost; Yupin Suputtamongkol; Roongreung Limpaiboon; Arjen Dondorp; Nicholas J. White; Tom van der Poll

doi:https://doi.org/10.1016/j.clim.2004.08.006

Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis

Wirongrong Chierakul, Maaike de Fost, Yupin Suputtamongkol, Roongreung Limpaiboon, Arjen Dondorp, Nicholas J. White, Tom van der Poll

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Interferon (IFN)-gamma plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-gamma and IFN-gamma-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-gamma, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-alpha concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi. (C) 2004 Elsevier Inc. All rights reserved

Original language	English
Pages (from-to)	140-144
Journal	Clinical immunology (Orlando, Fla.)
Volume	113
Issue number	2
DOIs	https://doi.org/10.1016/j.clim.2004.08.006
Publication status	Published - 2004

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https://doi.org/10.1016/j.clim.2004.08.006

Cite this

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title = "Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis",

abstract = "Interferon (IFN)-gamma plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-gamma and IFN-gamma-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-gamma, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-alpha concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi. (C) 2004 Elsevier Inc. All rights reserved",

author = "Wirongrong Chierakul and {de Fost}, Maaike and Yupin Suputtamongkol and Roongreung Limpaiboon and Arjen Dondorp and White, {Nicholas J.} and {van der Poll}, Tom",

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T1 - Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis

AU - Chierakul, Wirongrong

AU - de Fost, Maaike

AU - Suputtamongkol, Yupin

AU - Limpaiboon, Roongreung

AU - Dondorp, Arjen

AU - White, Nicholas J.

AU - van der Poll, Tom

PY - 2004

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AB - Interferon (IFN)-gamma plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-gamma and IFN-gamma-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-gamma, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-alpha concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi. (C) 2004 Elsevier Inc. All rights reserved

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DO - https://doi.org/10.1016/j.clim.2004.08.006

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